ATE79114T1 - AROMATIC AND HETEROCYCLIC CARBOXAMIDES AS ANTINEOPLASTIC AGENTS. - Google Patents

AROMATIC AND HETEROCYCLIC CARBOXAMIDES AS ANTINEOPLASTIC AGENTS.

Info

Publication number
ATE79114T1
ATE79114T1 AT89305141T AT89305141T ATE79114T1 AT E79114 T1 ATE79114 T1 AT E79114T1 AT 89305141 T AT89305141 T AT 89305141T AT 89305141 T AT89305141 T AT 89305141T AT E79114 T1 ATE79114 T1 AT E79114T1
Authority
AT
Austria
Prior art keywords
aromatic
antineoplastic agents
heterocyclic carboxamides
carboxamides
heterocyclic
Prior art date
Application number
AT89305141T
Other languages
German (de)
Inventor
Anton Franz Josef Fliri
Rodney Caughren Schnur
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE79114T1 publication Critical patent/ATE79114T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Graft Or Block Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Acyl derivatives of 2-aminobenzothiazole and alkylated analogs thereof as antitumor agents.
AT89305141T 1988-05-24 1989-05-22 AROMATIC AND HETEROCYCLIC CARBOXAMIDES AS ANTINEOPLASTIC AGENTS. ATE79114T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24
EP89305141A EP0343893B1 (en) 1988-05-24 1989-05-22 Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents

Publications (1)

Publication Number Publication Date
ATE79114T1 true ATE79114T1 (en) 1992-08-15

Family

ID=22731735

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89305141T ATE79114T1 (en) 1988-05-24 1989-05-22 AROMATIC AND HETEROCYCLIC CARBOXAMIDES AS ANTINEOPLASTIC AGENTS.

Country Status (25)

Country Link
EP (1) EP0343893B1 (en)
JP (1) JPH0678331B2 (en)
KR (1) KR910006864B1 (en)
CN (1) CN1023700C (en)
AT (1) ATE79114T1 (en)
AU (1) AU601905B2 (en)
CA (1) CA1328871C (en)
DD (1) DD283815A5 (en)
DE (1) DE68902358T2 (en)
DK (1) DK249389A (en)
ES (1) ES2043012T3 (en)
FI (1) FI892498A (en)
GR (1) GR3005844T3 (en)
HU (1) HU202507B (en)
IE (1) IE891667L (en)
IL (1) IL90337A0 (en)
MX (1) MX173140B (en)
MY (1) MY106035A (en)
NO (1) NO172389C (en)
NZ (1) NZ229234A (en)
PL (1) PL154875B1 (en)
PT (1) PT90622B (en)
SU (1) SU1681728A3 (en)
YU (1) YU47019B (en)
ZA (1) ZA893862B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2790299B2 (en) * 1989-02-01 1998-08-27 保土谷化学工業株式会社 Penzothiazole derivative
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
ATE203234T1 (en) 1995-08-30 2001-08-15 Searle & Co META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINOBENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
HUP0102101A3 (en) 1997-11-10 2002-11-28 Bristol Myers Squibb Co Protein tyrosine kinase inhibitor benzothiazole derivatives and pharmaceutical compositions containing them
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
WO1999052861A1 (en) * 1998-04-09 1999-10-21 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Novel benzyl guanidine derivatives for therapy and in-vivo and in-vitro diagnosis
MXPA02012596A (en) * 2000-06-21 2003-04-10 Hoffmann La Roche Benzothiazole derivatives.
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) * 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (en) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 Methionyl aminopeptidase inhibitor
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
JP4668265B2 (en) 2004-05-24 2011-04-13 エフ．ホフマン−ラ ロシュ アーゲー 4-Hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl) -amide
ATE400557T1 (en) 2004-11-05 2008-07-15 Hoffmann La Roche METHOD FOR PRODUCING ISONICOTINIC ACID DERIVATIVES
MX2007011483A (en) 2005-03-23 2007-10-12 Hoffmann La Roche Acetylenyl-pyrazolo-pvrimidine derivatives as mglur2 antagonists.
CA2623721C (en) 2005-09-27 2014-05-13 F. Hoffmann-La Roche Ag Oxadiazolyl pyrazolo-pyrimidines as mglur2 antagonists
CN101405278A (en) * 2006-03-15 2009-04-08 4Sc股份公司 Novel heterocyclic NF-kB inhibitors
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
US20110178070A1 (en) * 2008-06-24 2011-07-21 Takeda Pharmaceutical Company Limited PI3K/mTOR INHIBITORS
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
SG11201401084TA (en) * 2011-09-30 2014-04-28 Kineta Inc Anti-viral compounds
WO2013111875A1 (en) 2012-01-27 2013-08-01 国立大学法人京都大学 Method for inducing differentiation of pluripotent stem cell into cardiac muscle
WO2014136519A1 (en) 2013-03-08 2014-09-12 国立大学法人京都大学 Promoter of differentiation of pluripotent stem cell into myocardium, which comprises egf receptor inhibitor
JP6333830B2 (en) * 2013-09-13 2018-05-30 国立大学法人京都大学 Compounds that promote myocardial differentiation of pluripotent stem cells
WO2015182765A1 (en) 2014-05-30 2015-12-03 国立大学法人京都大学 Method for inducing myocardial differentiation of pluripotent stem cells using low-molecular compound
CN109776486A (en) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 A kind of preparation method of sulfuric acid Asia propyl ester
CN110590735B (en) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 Preparation method of cyclic sulfate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61225168A (en) * 1985-03-30 1986-10-06 Nippon Tokushu Noyaku Seizo Kk Novel benzamide, production thereof and insecticide
KR930005004B1 (en) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. Process for preparing substituted n-|(4-piperidinyl) alkyl¨ bicycle condensed oxazole and thiazolamines
GB8611606D0 (en) * 1986-05-13 1986-06-18 Fbc Ltd Fungicides

Also Published As

Publication number Publication date
ES2043012T3 (en) 1993-12-16
DK249389D0 (en) 1989-05-23
JPH0678331B2 (en) 1994-10-05
SU1681728A3 (en) 1991-09-30
NO172389C (en) 1993-07-14
GR3005844T3 (en) 1993-06-07
IL90337A0 (en) 1989-12-15
PL279613A1 (en) 1989-11-27
DK249389A (en) 1989-11-27
PT90622B (en) 1994-10-31
MY106035A (en) 1995-03-31
NZ229234A (en) 1990-09-26
EP0343893A1 (en) 1989-11-29
NO892059L (en) 1989-11-27
IE891667L (en) 1989-11-24
DE68902358D1 (en) 1992-09-10
EP0343893B1 (en) 1992-08-05
PL154875B1 (en) 1991-09-30
YU47019B (en) 1994-11-15
MX173140B (en) 1994-02-02
JPH0217181A (en) 1990-01-22
MX16158A (en) 1993-06-01
NO172389B (en) 1993-04-05
DE68902358T2 (en) 1992-12-10
KR890017248A (en) 1989-12-15
FI892498A (en) 1989-11-25
CN1023700C (en) 1994-02-09
FI892498A0 (en) 1989-05-23
YU105989A (en) 1990-08-31
CA1328871C (en) 1994-04-26
HUT51606A (en) 1990-05-28
DD283815A5 (en) 1990-10-24
AU3509889A (en) 1989-11-30
NO892059D0 (en) 1989-05-23
AU601905B2 (en) 1990-09-20
HU202507B (en) 1991-03-28
ZA893862B (en) 1991-01-30
CN1037898A (en) 1989-12-13
PT90622A (en) 1989-11-30
KR910006864B1 (en) 1991-09-09

Similar Documents

Publication Publication Date Title
DE68902358D1 (en) AROMATIC AND HETEROCYCLIC CARBOXAMIDES AS ANTINEOPLASTIC AGENTS.
DK143986A (en) 1,2-BENZISOXAZOL-3-YL AND 1,2-BENZISOTHIAZOL-3-YL DERIVATIVES
DK173486D0 (en) Heterocyclic Amide Derivatives
DE68914197D1 (en) Alkanoic acid derivatives and herbicidal agents.
FR2622106B1 (en) NEW THERAPEUTIC APPLICATION OF 4H-BENZO (4,5) CYCLO-HEPTA (1,2-B) THIOPHENE DERIVATIVES
DE69030030D1 (en) 4-acyloxyquinoline derivatives and insecticidal and acaricidal agents containing them
DE3875866D1 (en) SULFONAMIDOLPHENYL DERIVATIVES AND THERAPEUTIC AND PREVENTIVE AGENTS AGAINST ARRHYTHMIA.
DE68926733D1 (en) Piperidine derivatives and hypotensives containing them
DE3782636D1 (en) ISOINDOLIN-1-ON DERIVATIVE AND ANTI-ARRHYTHMIC AGENT.
MC1920A1 (en) ACYL DERIVATIVES
NO944906L (en) New use of benzo [gÅquoline derivatives
DE3674017D1 (en) OXALURIC ACID DERIVATIVES AND PHARMACEUTICAL AGENTS.
ES2129053T3 (en) NEW DERIVATIVES OF PHOSFOLIPIDS.
DE68919512D1 (en) Quinoxaline derivatives and anti-ulcerant.
DE59009786D1 (en) Multivibrator circuit independent of temperature and supply voltage.
DE3671630D1 (en) GLYCERO-3 (2) -PHOSPHO-L-SERINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
DE3769332D1 (en) DERIVATIVES OF PYRIDO-MENADION ADDITION PRODUCTS AND USES THEREOF.
MC1848A1 (en) ISOPRENE DERIVATIVES
DE3852245D1 (en) Derivatives of isoprene and anti-ulcer agents containing them.
DE3688032D1 (en) AMIDE DERIVATIVES AND 5-LIPOXYGENASE INHIBITORS CONTAINING THEM.
DE69123168D1 (en) Piperidine derivatives and antiulcer preparations containing them
LV5778A4 (en) 1,2-Benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives
ATE109773T1 (en) ACYLATION PRODUCTS FROM 9,10-
ATE53214T1 (en) GLYCERO-3(2)-PHOSPHO-L-SERINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
ATE62678T1 (en) DERIVATIVES OF PYRIDO-MENADION ADDITION PRODUCTS AND USES THEREOF.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee