ATE78474T1 - PROCESS FOR THE PREPARATION OF PYRIMIDI DERIVATIVES. - Google Patents

PROCESS FOR THE PREPARATION OF PYRIMIDI DERIVATIVES.

Info

Publication number
ATE78474T1
ATE78474T1 AT87810260T AT87810260T ATE78474T1 AT E78474 T1 ATE78474 T1 AT E78474T1 AT 87810260 T AT87810260 T AT 87810260T AT 87810260 T AT87810260 T AT 87810260T AT E78474 T1 ATE78474 T1 AT E78474T1
Authority
AT
Austria
Prior art keywords
mercapto
formula
image
fluoroalkoxypyrimidine
preparation
Prior art date
Application number
AT87810260T
Other languages
German (de)
Inventor
Robert Dr Haessig
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Application granted granted Critical
Publication of ATE78474T1 publication Critical patent/ATE78474T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention relates to a process for the preparation of 2-mercapto-4,6-bis-fluoroalkoxypyrimidines of the formula <IMAGE> wherein R1 is C1-C4alkyl, phenyl or benzyl and each of T1 and T2 independently of the other is hydrogen or a -CHX1X2 group, wherein each of X1 and X2 independently of the other is trifluoromethyl, fluorine, chlorine or bromine. In accordance with this process, 2-mercapto-4-halo-6-hydroxy-pyrimidines of the formula <IMAGE> wherein R1 is as defined above and Y is chlorine or bromine, are reacted with chlorodifluoromethane or a 1,1-difluoroalkene of the formula <IMAGE> wherein each of the X1 and X2 independently of the other is trifluoromethyl, fluorine, chlorine or bromine, in an inert solvent and in the presence of a strong base, to give a 2-mercapto-4-halo-6-fluoro-alkoxypyrimidine of the formula <IMAGE> wherein R1, Y and T1 are as defined above, said 2-mercapto-4-halo-6-fluoroalkoxypyrimidine is converted by subsequent reaction with an alkali metal nitrite or an alkaline earth metal nitrite into a 2-mercapto-4-hydroxy-6-fluoroalkoxypyrimidine of the formula <IMAGE> wherein R1 and T1 are as defined above, and then said 2-mercapto-4-hydroxy-6-fluoroalkoxypyrimidine is converted by reaction with chlorodifluoromethane or a 1,1-difluoroalkene of the above formula into a 2-mercapto-4,6-bix-fluoroalkoxypyrimidine of the above formula. The 2-mercapto-4,6-bis-fluoroalkoxypyrimidines of the above formula are intermediates for the preparation of herbicidally effective sulfonylureas.
AT87810260T 1986-05-02 1987-04-24 PROCESS FOR THE PREPARATION OF PYRIMIDI DERIVATIVES. ATE78474T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/858,636 US4692524A (en) 1986-05-02 1986-05-02 Process for the preparation of pyrimidine derivatives
EP87810260A EP0244359B1 (en) 1986-05-02 1987-04-24 Process for the preparation of pyrimidine derivatives

Publications (1)

Publication Number Publication Date
ATE78474T1 true ATE78474T1 (en) 1992-08-15

Family

ID=25328782

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87810260T ATE78474T1 (en) 1986-05-02 1987-04-24 PROCESS FOR THE PREPARATION OF PYRIMIDI DERIVATIVES.

Country Status (8)

Country Link
US (1) US4692524A (en)
EP (1) EP0244359B1 (en)
JP (1) JPH0629265B2 (en)
KR (2) KR900006837B1 (en)
AT (1) ATE78474T1 (en)
DE (1) DE3780504D1 (en)
ES (1) ES2042600T3 (en)
GR (1) GR3005854T3 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900827A (en) * 1988-12-22 1990-02-13 Ciba-Geigy Corporation Process for the preparation of pyrimidine derivatives
JPH0662588B2 (en) * 1989-01-24 1994-08-17 川口化学工業株式会社 Process for producing 4,6-bis (difluoromethoxy) -2-methylthiopyrimidine
DE3914714A1 (en) * 1989-05-04 1990-11-22 Bayer Ag PYRIMIDINYL (THIONO) (THIOL) -PHOSPHOR (PHOSPHON) ACID (AMID) ESTER
CA2076690C (en) * 1991-08-30 2003-01-07 Jean-Paul Roduit Process for the production of 2-(methylthio)-disodium barbiturate
US5780202A (en) * 1994-04-08 1998-07-14 Toyo Boseki Kabushiki Kaisha Antistatic photosensitive multilayered structure and method for producing the same
CA2208734C (en) * 1996-07-24 2006-05-30 Lonza Ag Process for preparing 4,6-bis(difluoro-methoxy)pyrimidine derivatives
CN101456845B (en) * 2008-06-24 2010-11-03 陕西师范大学 4,5-diaryl-2-sulfhydryl miazines compounds and synthetic method thereof and pharmaceutical use
KR101713184B1 (en) * 2015-07-20 2017-03-22 솔로몬 시스테크 리미티드 Method for detecting short defection of self-capacitance type touch sensor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4480101A (en) * 1981-07-16 1984-10-30 Ciba-Geigy Corporation Fluoroalkoxy-aminopyrimidines
US4545811A (en) * 1981-08-06 1985-10-08 Ciba-Geigy Corporation N-Phenylsulfonyl-N'-triazinyl-ureas
MA19680A1 (en) * 1982-01-11 1983-10-01 Novartis Ag N- ARYLSULFONYL - N '- PYRIMIDINYLUREES.
US4478635A (en) * 1982-01-11 1984-10-23 Ciba-Geigy Corporation N-Arylsulfonyl-N'-pyrimidinylureas
BR8302396A (en) * 1982-05-12 1984-01-10 Du Pont COMPOUND, COMPOSITION AND PROCESS PROPER TO CONTROL THE GROWTH OF UNWANTED VEGETATION
US4542216A (en) * 1984-03-27 1985-09-17 Ciba Geigy Corporation Process for producing fluoroalkoxyaminopyrimidines

Also Published As

Publication number Publication date
US4692524A (en) 1987-09-08
GR3005854T3 (en) 1993-06-07
ES2042600T3 (en) 1993-12-16
KR920006782B1 (en) 1992-08-17
EP0244359A2 (en) 1987-11-04
EP0244359B1 (en) 1992-07-22
KR900006837B1 (en) 1990-09-22
EP0244359A3 (en) 1987-12-23
JPS62281869A (en) 1987-12-07
JPH0629265B2 (en) 1994-04-20
DE3780504D1 (en) 1992-08-27
KR870011106A (en) 1987-12-21
KR920002007A (en) 1992-01-30

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