ATE68189T1 - Reinigung von haemoglobin und modifiziertem haemoglobin mittels affinitaetschromatographie. - Google Patents

Reinigung von haemoglobin und modifiziertem haemoglobin mittels affinitaetschromatographie.

Info

Publication number
ATE68189T1
ATE68189T1 AT86904259T AT86904259T ATE68189T1 AT E68189 T1 ATE68189 T1 AT E68189T1 AT 86904259 T AT86904259 T AT 86904259T AT 86904259 T AT86904259 T AT 86904259T AT E68189 T1 ATE68189 T1 AT E68189T1
Authority
AT
Austria
Prior art keywords
haemoglobin
purification
affinity chromatography
modified
modified haemoglobin
Prior art date
Application number
AT86904259T
Other languages
English (en)
Inventor
Jen-Chang Hsia
Original Assignee
Hemosol Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemosol Inc filed Critical Hemosol Inc
Application granted granted Critical
Publication of ATE68189T1 publication Critical patent/ATE68189T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT86904259T 1985-06-26 1986-06-26 Reinigung von haemoglobin und modifiziertem haemoglobin mittels affinitaetschromatographie. ATE68189T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA000485392A CA1244349A (en) 1985-06-26 1985-06-26 Purification of hemoglobin and modified hemoglobin by affinity chromatography
PCT/GB1986/000374 WO1987000177A1 (en) 1985-06-26 1986-06-26 Purification of hemoglobin and modified hemoglobin by affinity chromatography
EP86904259A EP0231236B1 (de) 1985-06-26 1986-06-26 Reinigung von hämoglobin und modifiziertem hämoglobin mittels affinitätschromatographie

Publications (1)

Publication Number Publication Date
ATE68189T1 true ATE68189T1 (de) 1991-10-15

Family

ID=4130840

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86904259T ATE68189T1 (de) 1985-06-26 1986-06-26 Reinigung von haemoglobin und modifiziertem haemoglobin mittels affinitaetschromatographie.

Country Status (17)

Country Link
US (1) US4925574A (de)
EP (1) EP0231236B1 (de)
JP (1) JPS63500305A (de)
CN (1) CN86104458A (de)
AR (1) AR241140A1 (de)
AT (1) ATE68189T1 (de)
AU (1) AU595819B2 (de)
CA (1) CA1244349A (de)
DE (1) DE3681909D1 (de)
DK (1) DK95987D0 (de)
ES (1) ES8900050A1 (de)
GB (1) GB2178742B (de)
IL (1) IL79147A0 (de)
MX (1) MX168403B (de)
NZ (1) NZ216639A (de)
WO (1) WO1987000177A1 (de)
ZA (1) ZA864697B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
JP2732252B2 (ja) * 1987-12-07 1998-03-25 株式会社ジェイ・エム・エス ヘモグロビン選択吸着剤
CA1338244C (en) * 1988-08-17 1996-04-09 Xiang-Fu Wu Purification of hemoglobin and methemoglobin by bioselective elution
JP3273944B2 (ja) * 1991-11-25 2002-04-15 エクソンモービル・ケミカル・パテンツ・インク ポリアニオン性遷移金属触媒組成物
US6187744B1 (en) 1992-03-11 2001-02-13 Michael W. Rooney Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject
US5739037A (en) * 1992-09-29 1998-04-14 Drew Scientific Limited Process for eliminating labile glycohaemoglobin from a sample
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5578564A (en) * 1993-07-23 1996-11-26 Somatogen, Inc. Nickel-free hemoglobin and methods for producing such hemoglobin
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) * 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
CA2106612C (en) * 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5456835A (en) * 1993-11-08 1995-10-10 Hemasure, Inc. Device and process for removing free hemoglobin from blood
US5665869A (en) * 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US6150507A (en) * 1995-03-23 2000-11-21 Biopure Corporation Method for producing a purified hemoglobin product
US5691453A (en) * 1995-06-07 1997-11-25 Biopure Corporation Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC
JPH0912598A (ja) * 1995-06-29 1997-01-14 Sekisui Chem Co Ltd ヘモグロビンの分離精製方法
US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
JP2000502058A (ja) * 1995-11-30 2000-02-22 ソマトジェン，インコーポレイテッド ヘモグロビン架橋の際の機能性制御のための方法
US7531632B2 (en) 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
AU2014285971A1 (en) 2013-07-05 2016-02-04 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Affinity chromatography matrix
TWI626248B (zh) * 2016-12-09 2018-06-11 中華醫事科技大學 血紅素及肌紅素之分離方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US32011A (en) * 1861-04-09 Coffee-pot
US3350174A (en) * 1964-01-08 1967-10-31 Miles Lab Process of determining hemoglobin separated from peroxidase inhibitors in urine
US4011377A (en) * 1971-02-11 1977-03-08 Peter Duncan Goodearl Dean Enzyme separation
DE2319495C2 (de) * 1973-04-17 1985-01-10 Yeda Research And Development Co., Ltd., Rehovot Verfahren zum selektiven, reversiblen Binden von Biomolekülen an ein Adsorbens in einer chromatographischen Säule
US3873514A (en) * 1974-05-17 1975-03-25 Bio Rad Laboratories Preparation of gel for affinity chromatography
IL49752A (en) * 1975-07-09 1979-07-25 Kabi Ab Compositions having affinity for hepatitis virus and method for hepatitis virus removal or concentration
US4143203A (en) * 1976-03-19 1979-03-06 Amicon Corporation Particulate support material
DD149861A3 (de) * 1976-08-12 1981-08-05 Klaus Pommerening Verfahren zur trennung bzw.reinigung von proteinen
DE2652636A1 (de) * 1976-11-19 1978-05-24 Hans Uwe Dr Rer Nat Wolf Verfahren zur stabilisierung von proteinen und verwandten verbindungen waehrend ihrer reinigung, isolierung und lagerung
US4330440A (en) * 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
JPS5564599A (en) * 1978-11-08 1980-05-15 Unitika Ltd Adenosine triphosphate derivative
USRE32011E (en) 1981-12-14 1985-10-22 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies

Also Published As

Publication number Publication date
CA1244349A (en) 1988-11-08
DK95987A (da) 1987-02-25
WO1987000177A1 (en) 1987-01-15
JPS63500305A (ja) 1988-02-04
ES556778A0 (es) 1988-11-16
ES8900050A1 (es) 1988-11-16
IL79147A0 (en) 1986-09-30
MX168403B (es) 1993-05-24
AU6128186A (en) 1987-01-30
DK95987D0 (da) 1987-02-25
NZ216639A (en) 1988-09-29
GB2178742A (en) 1987-02-18
DE3681909D1 (de) 1991-11-14
GB2178742B (en) 1989-07-12
AR241140A1 (es) 1991-11-29
EP0231236A1 (de) 1987-08-12
CN86104458A (zh) 1987-07-01
US4925574A (en) 1990-05-15
ZA864697B (en) 1987-04-29
GB8615675D0 (en) 1986-07-30
AU595819B2 (en) 1990-04-12
EP0231236B1 (de) 1991-10-09
AR241140A2 (es) 1991-11-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee