ATE5796T1 - PHARMACEUTICAL COMPOSITION CONTAINING L-ALPHA-METHYL-3,4-DIHYDROXYPHENYLALANINE AND SALICYLAMIDE FOR THE TREATMENT OF HIGH BLOOD PRESSURE. - Google Patents

PHARMACEUTICAL COMPOSITION CONTAINING L-ALPHA-METHYL-3,4-DIHYDROXYPHENYLALANINE AND SALICYLAMIDE FOR THE TREATMENT OF HIGH BLOOD PRESSURE.

Info

Publication number
ATE5796T1
ATE5796T1 AT81102809T AT81102809T ATE5796T1 AT E5796 T1 ATE5796 T1 AT E5796T1 AT 81102809 T AT81102809 T AT 81102809T AT 81102809 T AT81102809 T AT 81102809T AT E5796 T1 ATE5796 T1 AT E5796T1
Authority
AT
Austria
Prior art keywords
dihydroxyphenylalanine
salicylamide
alpha
methyl
pharmaceutical composition
Prior art date
Application number
AT81102809T
Other languages
German (de)
Inventor
Stanley Vickers
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Application granted granted Critical
Publication of ATE5796T1 publication Critical patent/ATE5796T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The application discloses a pharmaceutical composition for treating hypertension containing (A) L- alpha -methyl-3,4-dihydroxyphenylalanine and (B) salicylamide, phenylglyoxal or L-ascorbic acid.
AT81102809T 1980-04-14 1981-04-13 PHARMACEUTICAL COMPOSITION CONTAINING L-ALPHA-METHYL-3,4-DIHYDROXYPHENYLALANINE AND SALICYLAMIDE FOR THE TREATMENT OF HIGH BLOOD PRESSURE. ATE5796T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/139,913 US4321264A (en) 1980-04-14 1980-04-14 α-methyldopa compositions
EP81102809A EP0038060B1 (en) 1980-04-14 1981-04-13 A pharmaceutical composition for treating hypertension containing l-alpha-methyl-3,4-dihydroxyphenylalanine and salicylamide

Publications (1)

Publication Number Publication Date
ATE5796T1 true ATE5796T1 (en) 1984-01-15

Family

ID=22488861

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81102809T ATE5796T1 (en) 1980-04-14 1981-04-13 PHARMACEUTICAL COMPOSITION CONTAINING L-ALPHA-METHYL-3,4-DIHYDROXYPHENYLALANINE AND SALICYLAMIDE FOR THE TREATMENT OF HIGH BLOOD PRESSURE.

Country Status (8)

Country Link
US (1) US4321264A (en)
EP (1) EP0038060B1 (en)
JP (1) JPS56161326A (en)
AT (1) ATE5796T1 (en)
DE (1) DE3161869D1 (en)
GR (1) GR74873B (en)
IE (1) IE51805B1 (en)
PT (1) PT72802B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6021570B2 (en) * 1978-07-04 1985-05-28 三共株式会社 Method for manufacturing high concentration preparations of DOPAs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL263355A (en) * 1960-04-08
US3526698A (en) * 1968-04-11 1970-09-01 Merck & Co Inc Stabilization of levo-3-(3,4-dihydroxyphenyl)-2-methylalanine with sodium bisulfite and sorbitol
US3574834A (en) * 1969-04-30 1971-04-13 Merck & Co Inc Medicinal soporific composition
IL40597A (en) * 1971-11-11 1976-06-30 Ciba Geigy Ag Anti-hypertensively active pharmaceutical preparations containing an anti-hypertensively active amino acid and a beta-hydroxylase inhibitor
IE49218B1 (en) * 1978-12-01 1985-08-21 Merck & Co Inc Methyldopa composition

Also Published As

Publication number Publication date
GR74873B (en) 1984-07-12
IE810819L (en) 1981-10-14
EP0038060B1 (en) 1984-01-11
PT72802A (en) 1981-05-01
US4321264A (en) 1982-03-23
IE51805B1 (en) 1987-04-01
PT72802B (en) 1983-03-29
DE3161869D1 (en) 1984-02-16
EP0038060A1 (en) 1981-10-21
JPS56161326A (en) 1981-12-11

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee