ATE554104T1 - Domänen der konstanten region von immunoglobulinen mit verbesserter stabilität - Google Patents

Domänen der konstanten region von immunoglobulinen mit verbesserter stabilität

Info

Publication number
ATE554104T1
ATE554104T1 AT07755812T AT07755812T ATE554104T1 AT E554104 T1 ATE554104 T1 AT E554104T1 AT 07755812 T AT07755812 T AT 07755812T AT 07755812 T AT07755812 T AT 07755812T AT E554104 T1 ATE554104 T1 AT E554104T1
Authority
AT
Austria
Prior art keywords
sub
polypeptide
immunoglobulin
pro
region domain
Prior art date
Application number
AT07755812T
Other languages
English (en)
Inventor
Masazumi Matsumura
Jaby Jacob
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE554104T1 publication Critical patent/ATE554104T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT07755812T 2006-04-21 2007-04-20 Domänen der konstanten region von immunoglobulinen mit verbesserter stabilität ATE554104T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79420206P 2006-04-21 2006-04-21
US86077406P 2006-11-21 2006-11-21
PCT/US2007/009693 WO2007124077A2 (en) 2006-04-21 2007-04-20 Immunoglobulin constant region domains with enhanced stability

Publications (1)

Publication Number Publication Date
ATE554104T1 true ATE554104T1 (de) 2012-05-15

Family

ID=38625624

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07755812T ATE554104T1 (de) 2006-04-21 2007-04-20 Domänen der konstanten region von immunoglobulinen mit verbesserter stabilität

Country Status (6)

Country Link
EP (1) EP2027154B1 (de)
AT (1) ATE554104T1 (de)
AU (1) AU2007240727B2 (de)
CA (1) CA2649709A1 (de)
ES (1) ES2387023T3 (de)
WO (1) WO2007124077A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2766166A1 (en) 2009-07-08 2011-01-13 Amgen Inc. Design of stable and aggregation free antibody fc molecules through ch3 domain interface engineering
EP3586860A1 (de) * 2018-06-22 2020-01-01 Universität Ulm Komplement-inhibitoren und verwendungen davon

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US6277375B1 (en) * 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
WO2004074491A2 (en) * 2003-02-18 2004-09-02 Syngeta Participations Ag Expression in plants of antibodies against enterotoxigenic escherichia coli

Also Published As

Publication number Publication date
AU2007240727A1 (en) 2007-11-01
ES2387023T3 (es) 2012-09-11
EP2027154A2 (de) 2009-02-25
EP2027154B1 (de) 2012-04-18
WO2007124077A3 (en) 2008-08-07
AU2007240727B2 (en) 2013-12-19
WO2007124077A2 (en) 2007-11-01
CA2649709A1 (en) 2007-11-01

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