ATE503T1 - HEART AND KIDNEY PROTECTIVE SOLUTION AND PROCESS FOR PRODUCTION. - Google Patents
HEART AND KIDNEY PROTECTIVE SOLUTION AND PROCESS FOR PRODUCTION.Info
- Publication number
- ATE503T1 ATE503T1 AT79104734T AT79104734T ATE503T1 AT E503 T1 ATE503 T1 AT E503T1 AT 79104734 T AT79104734 T AT 79104734T AT 79104734 T AT79104734 T AT 79104734T AT E503 T1 ATE503 T1 AT E503T1
- Authority
- AT
- Austria
- Prior art keywords
- millimols
- heart
- solution
- production
- protective solution
- Prior art date
Links
- 210000003734 kidney Anatomy 0.000 title abstract 2
- 230000001681 protective effect Effects 0.000 title abstract 2
- 239000000243 solution Substances 0.000 abstract 3
- 210000000056 organ Anatomy 0.000 abstract 2
- QZNNVYOVQUKYSC-JEDNCBNOSA-N (2s)-2-amino-3-(1h-imidazol-5-yl)propanoic acid;hydron;chloride Chemical compound Cl.OC(=O)[C@@H](N)CC1=CN=CN1 QZNNVYOVQUKYSC-JEDNCBNOSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 239000006035 Tryptophane Substances 0.000 abstract 1
- 229910001413 alkali metal ion Inorganic materials 0.000 abstract 1
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
- 229960004799 tryptophan Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- External Artificial Organs (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Protective solution for preventing ischaemia damage to the heart and kidneys and other organs in the course of operations and transplantations of these organs whilst the blood circulation is shut out, characterised in that it consists of a buffer system based on 150 +- 100 millimols of histidine, 16 +- 10 millimols of histidine hydrochloride and 2 +- 1 millimols of tryptophane per litre, which additionally contains alkali metal ions and alkaline earth metal ions as well as a polyol or a sugar, the sum of the cations being 25-80 milliequivalents, the osmolarity of the solution being 300-400 mosm and the pH of the solution being between 6.6 and 7.6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1275778A CH639270A5 (en) | 1978-12-14 | 1978-12-14 | PROTECTIVE SOLUTION FOR HEART AND KIDNEY. |
| EP79104734A EP0012272B1 (en) | 1978-12-14 | 1979-11-28 | Protecting solution for heart and kidneys and process for its manufacture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE503T1 true ATE503T1 (en) | 1982-01-15 |
Family
ID=4386118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT79104734T ATE503T1 (en) | 1978-12-14 | 1979-11-28 | HEART AND KIDNEY PROTECTIVE SOLUTION AND PROCESS FOR PRODUCTION. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0012272B1 (en) |
| AT (1) | ATE503T1 (en) |
| CH (1) | CH639270A5 (en) |
| DE (1) | DE2961723D1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0054635B1 (en) * | 1980-12-23 | 1985-02-13 | Dr. Franz Köhler Chemie GmbH | Protective solution for heart and kidney, and manufacturing process |
| SE8403912D0 (en) * | 1984-07-30 | 1984-07-30 | Pharmacia Ab | PHARMACEUTICAL KIT OR COMPOSITION |
| FR2602677B1 (en) * | 1986-08-14 | 1992-03-06 | Blomet Marie Claude | PHYSIOLOGICAL SOLUTION FOR WASHING PARTS OF THE HUMAN OR ANIMAL BODY WHICH HAVE BEEN IN CONTACT WITH AN ACID OR A BASE, AND CONCENTRATED FOR ITS PREPARATION |
| US5092838A (en) * | 1989-11-30 | 1992-03-03 | Baxter International Inc. | Histidine buffered peritoneal dialysis solution |
| US5290766A (en) * | 1991-02-18 | 1994-03-01 | The National Heart Foundation Of New Zealand | Cardioplegic compositions |
| FR2715028B1 (en) * | 1994-01-17 | 1998-01-16 | Christine Charrueau | Compositions for organ preservation. |
| DE10222561B4 (en) | 2002-05-17 | 2009-12-10 | Dr. Franz Köhler Chemie GmbH | Protective solution for the prevention of ischemic damage |
| DE102007026392A1 (en) | 2007-06-06 | 2008-12-11 | Bayer Healthcare Ag | Solutions for the perfusion and preservation of organs and tissues |
-
1978
- 1978-12-14 CH CH1275778A patent/CH639270A5/en not_active IP Right Cessation
-
1979
- 1979-11-28 DE DE7979104734T patent/DE2961723D1/en not_active Expired
- 1979-11-28 EP EP79104734A patent/EP0012272B1/en not_active Expired
- 1979-11-28 AT AT79104734T patent/ATE503T1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH639270A5 (en) | 1983-11-15 |
| EP0012272B1 (en) | 1981-12-30 |
| EP0012272A1 (en) | 1980-06-25 |
| DE2961723D1 (en) | 1982-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |