ATE481134T1 - COMPOSITIONS AND USE OF TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF PATHOGENIC INFECTIONS - Google Patents

COMPOSITIONS AND USE OF TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF PATHOGENIC INFECTIONS

Info

Publication number
ATE481134T1
ATE481134T1 AT05705915T AT05705915T ATE481134T1 AT E481134 T1 ATE481134 T1 AT E481134T1 AT 05705915 T AT05705915 T AT 05705915T AT 05705915 T AT05705915 T AT 05705915T AT E481134 T1 ATE481134 T1 AT E481134T1
Authority
AT
Austria
Prior art keywords
tyrosine kinase
kinase inhibitors
compositions
treatment
pathogenic infections
Prior art date
Application number
AT05705915T
Other languages
German (de)
Inventor
Daniel Kalman
William Bornmann
Melanie Sherman
Patrick Reeves
Alyson Swimm
Original Assignee
Univ Emory
Sloan Kettering Inst Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory, Sloan Kettering Inst Cancer filed Critical Univ Emory
Application granted granted Critical
Publication of ATE481134T1 publication Critical patent/ATE481134T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Compositions and methods are provided for using tyrosine kinase inhibitors to treat pathogenic infection. In particular, methods for using Abl-family tyrosine kinase inhibitors to treat pathogenic infection are provided. Infections to be treated according to the present invention include, particularly, those caused by microbial pathogens such as bacteria and viruses.
AT05705915T 2004-01-21 2005-01-20 COMPOSITIONS AND USE OF TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF PATHOGENIC INFECTIONS ATE481134T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53796004P 2004-01-21 2004-01-21
US55368104P 2004-03-16 2004-03-16
US61420304P 2004-09-29 2004-09-29
PCT/US2005/001710 WO2005072826A2 (en) 2004-01-21 2005-01-20 Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection

Publications (1)

Publication Number Publication Date
ATE481134T1 true ATE481134T1 (en) 2010-10-15

Family

ID=34831196

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05705915T ATE481134T1 (en) 2004-01-21 2005-01-20 COMPOSITIONS AND USE OF TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF PATHOGENIC INFECTIONS

Country Status (8)

Country Link
US (1) US8765777B2 (en)
EP (3) EP1725295B1 (en)
JP (2) JP5520433B2 (en)
AT (1) ATE481134T1 (en)
AU (1) AU2005209231B8 (en)
CA (1) CA2554201C (en)
DE (1) DE602005023587D1 (en)
WO (1) WO2005072826A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1725295B1 (en) 2004-01-21 2010-09-15 Emory University Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection
TWI338004B (en) * 2004-02-06 2011-03-01 Bristol Myers Squibb Co Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
US7491725B2 (en) 2004-02-06 2009-02-17 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
TWI393565B (en) * 2004-06-04 2013-04-21 Bioniche Life Sciences Inc Use of imatinib mesylate to treat liver disorders and viral infections
WO2006017353A2 (en) * 2004-07-13 2006-02-16 GOVERNMENT OF THE UNITED STATES, as represented byTHE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Treatment of viral infections
TW200628156A (en) * 2004-11-04 2006-08-16 Bristol Myers Squibb Co Combination of a SRC kinase inhibitor and a BCR-ABL inhibitor for the treatment of proliferative diseases
WO2007002441A1 (en) * 2005-06-24 2007-01-04 Emory University Methods of use for non-atp competitive tyrosine kinase inhibitors to treat pathogenic infection
EP1862802B1 (en) * 2006-06-01 2008-12-10 Cellzome Ag Methods for the identification of ZAP-70 interacting molecules and for the purification of ZAP-70
US8268809B2 (en) 2006-09-05 2012-09-18 Emory University Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
US20080275030A1 (en) 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
WO2008151183A1 (en) 2007-06-04 2008-12-11 Avila Therapeutics, Inc. Heterocyclic compounds and uses thereof
US8367686B2 (en) 2007-06-07 2013-02-05 Intra-Cellular Therapies, Inc. Heterocycle compounds and uses thereof
WO2008153974A1 (en) 2007-06-07 2008-12-18 Intra-Cellular Therapies, Inc. Novel heterocycle compounds and uses thereof
JP6166534B2 (en) 2009-08-05 2017-07-19 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． Novel regulatory proteins and inhibitors
EP2571361A4 (en) 2010-05-19 2013-11-13 Univ North Carolina Pyrazolopyrimidine compounds for the treatment of cancer
WO2012118599A1 (en) * 2011-02-28 2012-09-07 Emory University C-abl tyrosine kinase inhibitors useful for inhibiting filovirus replication
ES2650630T3 (en) 2011-10-03 2018-01-19 The University Of North Carolina At Chapel Hill Pyrrolopyrimidine compounds for cancer treatment
CA2873878A1 (en) 2012-05-22 2013-11-28 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
US9487500B2 (en) 2012-10-04 2016-11-08 Inhibikase Therapeutics, Inc. Compounds and compositions thereof
WO2014062774A1 (en) 2012-10-17 2014-04-24 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
WO2014085225A1 (en) 2012-11-27 2014-06-05 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
EP2769722A1 (en) * 2013-02-22 2014-08-27 Ruprecht-Karls-Universität Heidelberg Compounds for use in inhibiting HIV capsid assembly
MX2015011514A (en) 2013-03-15 2016-08-11 Celgene Avilomics Res Inc Heteroaryl compounds and uses thereof.
TWI647220B (en) 2013-03-15 2019-01-11 美商西建卡爾有限責任公司 Heteroaryl compound and its use
KR102350704B1 (en) 2013-03-15 2022-01-13 셀젠 카르 엘엘씨 Heteroaryl compounds and uses thereof
EP2905024A1 (en) * 2014-02-07 2015-08-12 Institut Quimic De Sarriá Cets, Fundació Privada Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae
EP3129377A4 (en) * 2014-04-11 2017-12-20 The University of North Carolina at Chapel Hill Mertk-specific pyrimidine compounds
WO2017049036A1 (en) * 2015-09-16 2017-03-23 Emory University Use of kinase inhibitors to manage tuberculosis and other infectious diseases
US10709708B2 (en) 2016-03-17 2020-07-14 The University Of North Carolina At Chapel Hill Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor
US20200360477A1 (en) 2019-05-16 2020-11-19 Aerovate Therapeutics, Inc. Inhalable formulations for kinase inhibition
US11464776B2 (en) 2019-05-16 2022-10-11 Aerovate Therapeutics, Inc. Inhalable imatinib formulations, manufacture, and uses thereof
KR20220054808A (en) * 2019-09-04 2022-05-03 더 리전츠 오브 더 유니버시티 오브 캘리포니아 Functional and phenotypic regeneration of connective tissue through Npas2 inhibition
CN111925368B (en) * 2020-07-04 2021-11-05 中国医学科学院医药生物技术研究所 Pyrimidone derivatives, preparation method thereof and application thereof in resisting mycobacterium tuberculosis infection

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU11248A1 (en) 1927-03-29 1929-09-30 В.С. Григорьев Anthracene cleaning method
US3439089A (en) 1968-03-27 1969-04-15 Merck & Co Inc Medicated hard candy
US4439089A (en) 1978-10-12 1984-03-27 Dresser Industries, Inc. Boom arm with rock deflection feature
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
TW225528B (en) 1992-04-03 1994-06-21 Ciba Geigy Ag
IL115256A0 (en) * 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
GEP20012444B (en) 1994-11-14 2001-05-25 Warner Lambert Company Us 6-Aryl Pyrido[2,3-d]Pyrimidines and Naphthyridines, Pharmaceutical Composition on Their Basis and Application for Inhibiting Cellular Proliferation
CN1311678A (en) 1998-04-30 2001-09-05 巴斯福股份公司 Substituted tricyclic pyrazole derivatives with protein kinase activity
CN101481359A (en) 1999-04-15 2009-07-15 布里斯托尔-迈尔斯斯奎布公司 Cyclic protein tyrosine kinase inhibitors
ATE392215T1 (en) * 1999-12-22 2008-05-15 Scripps Research Inst MODULATORS AND INHIBITORS OF ANGIOGENESIS AND VASCULAR PERMEABILITY
JP2004520007A (en) * 2000-08-01 2004-07-08 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Gene expression profile of KSHV infection and method of treating KSHV infection
US7022711B2 (en) * 2000-08-04 2006-04-04 Warner-Lambert Company 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimidin-7-ones
PT1330452E (en) 2000-09-20 2009-01-22 Ortho Mcneil Pharm Inc Pyrazine derivatives as modulators of tyrosine kinases
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
US6503914B1 (en) * 2000-10-23 2003-01-07 Board Of Regents, The University Of Texas System Thienopyrimidine-based inhibitors of the Src family
MXPA03005777A (en) 2000-12-22 2005-02-14 Johnson & Johnson Substituted triazole diamine derivatives as kinase inhibitors.
US20040241226A1 (en) * 2001-09-20 2004-12-02 Alain Moussy Use of potent, selective and non-toxic c-kit inhibitors for treating bacterial infections
GB0125659D0 (en) 2001-10-25 2001-12-19 Ssl Int Plc Spermicides
FR2844452A1 (en) 2002-09-18 2004-03-19 Inst Gustave Roussy Igr Modulating dendritic cell activity, e.g. for treatment of viral infections, NK-sensitive tumors or autoimmune diseases, using inhibitors or specific tyrosine kinases, e.g. c-abl, bcr/abl and c-kit
US7384907B2 (en) 2002-12-13 2008-06-10 Duke University Method of treating infection with ABl tyrosine kinase inhibitors
WO2005003325A2 (en) * 2003-03-11 2005-01-13 Dana Farber Cancer Institute Inhibition of viral pathogenesis
EP1725295B1 (en) 2004-01-21 2010-09-15 Emory University Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection
WO2005105097A2 (en) * 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
TWI393565B (en) * 2004-06-04 2013-04-21 Bioniche Life Sciences Inc Use of imatinib mesylate to treat liver disorders and viral infections
WO2007002441A1 (en) 2005-06-24 2007-01-04 Emory University Methods of use for non-atp competitive tyrosine kinase inhibitors to treat pathogenic infection
US8268809B2 (en) 2006-09-05 2012-09-18 Emory University Kinase inhibitors for preventing or treating pathogen infection and method of use thereof

Also Published As

Publication number Publication date
JP5520433B2 (en) 2014-06-11
EP2233174B1 (en) 2016-07-20
DE602005023587D1 (en) 2010-10-28
EP1725295B1 (en) 2010-09-15
US20110281867A1 (en) 2011-11-17
AU2005209231A1 (en) 2005-08-11
US8765777B2 (en) 2014-07-01
JP2007518810A (en) 2007-07-12
CA2554201A1 (en) 2005-08-11
EP2233174A1 (en) 2010-09-29
JP2010202674A (en) 2010-09-16
AU2005209231B8 (en) 2011-07-28
WO2005072826A3 (en) 2006-04-20
EP2260849A1 (en) 2010-12-15
WO2005072826A2 (en) 2005-08-11
AU2005209231B2 (en) 2011-03-17
CA2554201C (en) 2015-04-14
EP1725295A2 (en) 2006-11-29

Similar Documents

Publication Publication Date Title
ATE481134T1 (en) COMPOSITIONS AND USE OF TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF PATHOGENIC INFECTIONS
MA33806B1 (en) INHIBITORS OF HEPATITIS C VIRUS
DE602005012276D1 (en) USE OF PROBIOTIC BACTERIA FOR THE PREPARATION OF TOPICAL COMPOSITIONS FOR THE PROTECTION OF THE SKIN
DE60309701D1 (en) 2-UREIDO-6-HETEROARYL-3H-BENZOIMIDAZOLE-4-CARBOXYLENE DERIVATIVES AND RELATED COMPOUNDS AS GYRASE AND / OR TOPOISOMERASE IV INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS
ATE489957T1 (en) AGENTS FOR THE TREATMENT OF INFLAMMATORY DISEASES
HK1137366A1 (en) Pharmaceutical compositions comprising activin-actriia antagonists and use thereof in preventing or treating multiple myeloma
DE602008004317D1 (en) COMPOUNDS FOR THE TREATMENT OF HEPATITIS C
ATE551343T1 (en) TETRACYCLIC COMPOUNDS FOR THE TREATMENT OF HEPATITIS C
ATE492542T1 (en) PREPARATION AND USE OF BIPHENYL-4-YL CARBONYLAMINOSIC ACID DERIVATIVES FOR THE TREATMENT OF OBESITAS
ATE506951T1 (en) TERTIARY CARBINAMINES ACTIVE AS INHIBITORS OF BETA-SECRETASE WITH SUBSTITUTED HETEROCYCLES FOR THE TREATMENT OF ALZHEIMER'S DISEASE
EA200702493A1 (en) CONNECTIONS AND METHODS OF TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
ATE439863T1 (en) OPHTHALMIC PARASYMPATHIC STIMULANT AND ANTI-INFLAMMATORY COMPOSITIONS FOR USE IN THE TREATMENT OF PRESBYOPIA
DE602004014117D1 (en) THIAZOLE FOR USE AS INHIBITORS OF PROTEIN KINASES
NO20082862L (en) Novel alkylphospholipid derivatives with reduced cytotoxicity and use thereof
DE602008006257D1 (en) CYCLOPROPYL-CONDENSED INDOLOBENZAZEPINE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C
EA201100874A1 (en) COMPOUNDS FOR CANCER TREATMENT
DE60307749D1 (en) Use of flavonoid derivatives for the treatment of atopic eczema
EA200702583A1 (en) USE OF PHYLICEMIC BARBONS FOR TREATING SEEDS
ATE555108T1 (en) POLYAMIDES FOR THE TREATMENT OF HUMAN PAPILLOMA VIRUS
ATE445644T1 (en) APPLICATION OF MOLECULES AND METHODS TO TREAT MCP-1/CCR2 ASSOCIATED DISEASES
DE602005018366D1 (en) FOR THE TREATMENT OF 4-PIPERAZINYLPYRIMIDIN COMPOUNDS SUITABLE FOR MODULATION OF THE DOPAMIN D3 RECEPTOR
DE602004022689D1 (en) USE OF PROBIOTIC BACTERIA FOR THE TREATMENT OF INFECTIONS
ATE473277T1 (en) COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF IMMUNE-MEDIATED INFLAMMATORY DISEASES
WO2010052575A3 (en) Ngna compositions and methods of use
ATE498398T1 (en) CYCLOALKYL HETEROCYCLES FOR THE TREATMENT OF HEPATITIS C VIRUS

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties