ATE478144T1 - INHIBITORS OF DNA SYNTHESIS FROM AGING CELLS - Google Patents
INHIBITORS OF DNA SYNTHESIS FROM AGING CELLSInfo
- Publication number
- ATE478144T1 ATE478144T1 AT94927257T AT94927257T ATE478144T1 AT E478144 T1 ATE478144 T1 AT E478144T1 AT 94927257 T AT94927257 T AT 94927257T AT 94927257 T AT94927257 T AT 94927257T AT E478144 T1 ATE478144 T1 AT E478144T1
- Authority
- AT
- Austria
- Prior art keywords
- dna synthesis
- inhibitors
- inhibitory
- disclosed
- aging cells
- Prior art date
Links
- 230000006820 DNA synthesis Effects 0.000 title abstract 3
- 230000032683 aging Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 abstract 4
- 239000002299 complementary DNA Substances 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 230000032677 cell aging Effects 0.000 abstract 1
- 230000010094 cellular senescence Effects 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000002825 functional assay Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000005740 tumor formation Effects 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
<P>PROBLEM TO BE SOLVED: To provide a means for achieving cloning of an inhibitory factor of DNA synthesis using functional assay. <P>SOLUTION: A cDNA clone encoding an inhibitory factor of DNA synthesis is isolated using a cDNA library of senescent cell-derived expression vectors. Such inhibitory factors play a role in cellular senescence, ageing and tumor formation. There are disclosed such molecules, these inhibitory factors, antagonists, antisense nucleic acids thereto and derivatives thereof. Also disclosed are diagnostic, therapeutic and in vitro use of all these medicinal components. <P>COPYRIGHT: (C)2010,JPO&INPIT
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11337293A | 1993-08-30 | 1993-08-30 | |
| US15356493A | 1993-11-17 | 1993-11-17 | |
| US08/160,814 US5424400A (en) | 1991-12-16 | 1994-01-03 | Senescent cell derived inhibitors of DNA synthesis |
| US20353594A | 1994-02-25 | 1994-02-25 | |
| US22942094A | 1994-04-15 | 1994-04-15 | |
| US26843994A | 1994-06-30 | 1994-06-30 | |
| US27453594A | 1994-07-13 | 1994-07-13 | |
| PCT/US1994/009700 WO1995006415A1 (en) | 1993-08-30 | 1994-08-26 | Senescent cell-derived inhibitors of dna synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478144T1 true ATE478144T1 (en) | 2010-09-15 |
Family
ID=41734438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94927257T ATE478144T1 (en) | 1993-08-30 | 1994-08-26 | INHIBITORS OF DNA SYNTHESIS FROM AGING CELLS |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2010029199A (en) |
| AT (1) | ATE478144T1 (en) |
| DE (1) | DE69435309D1 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5302706A (en) * | 1991-12-16 | 1994-04-12 | Baylor College Of Medicine | Senescent cell derived inhibitors of DNA synthesis |
-
1994
- 1994-08-26 DE DE69435309T patent/DE69435309D1/en not_active Expired - Lifetime
- 1994-08-26 AT AT94927257T patent/ATE478144T1/en not_active IP Right Cessation
-
2009
- 2009-09-24 JP JP2009219470A patent/JP2010029199A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010029199A (en) | 2010-02-12 |
| DE69435309D1 (en) | 2010-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |