ATE463511T1 - Verwendung von cardiotrophin zur modulation der stammzellenproliferation - Google Patents
Verwendung von cardiotrophin zur modulation der stammzellenproliferationInfo
- Publication number
- ATE463511T1 ATE463511T1 AT04737879T AT04737879T ATE463511T1 AT E463511 T1 ATE463511 T1 AT E463511T1 AT 04737879 T AT04737879 T AT 04737879T AT 04737879 T AT04737879 T AT 04737879T AT E463511 T1 ATE463511 T1 AT E463511T1
- Authority
- AT
- Austria
- Prior art keywords
- cell proliferation
- stem cell
- methods
- cardiotrophin
- cells
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 7
- 230000004663 cell proliferation Effects 0.000 title abstract 5
- 238000000034 method Methods 0.000 abstract 5
- 102100028892 Cardiotrophin-1 Human genes 0.000 abstract 3
- 108010041776 cardiotrophin 1 Proteins 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000002950 deficient Effects 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48200103P | 2003-06-25 | 2003-06-25 | |
| PCT/CA2004/000940 WO2004113380A1 (en) | 2003-06-25 | 2004-06-25 | Use of cardiotrophin to modulate stem cell proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE463511T1 true ATE463511T1 (de) | 2010-04-15 |
Family
ID=33539330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04737879T ATE463511T1 (de) | 2003-06-25 | 2004-06-25 | Verwendung von cardiotrophin zur modulation der stammzellenproliferation |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20060115464A1 (de) |
| EP (1) | EP1639003B1 (de) |
| JP (1) | JP4838710B2 (de) |
| CN (1) | CN1812996A (de) |
| AT (1) | ATE463511T1 (de) |
| AU (1) | AU2004249340B2 (de) |
| CA (1) | CA2570464A1 (de) |
| DE (1) | DE602004026445D1 (de) |
| ES (1) | ES2344204T3 (de) |
| NZ (1) | NZ544828A (de) |
| WO (1) | WO2004113380A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7862810B2 (en) * | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US20050129616A1 (en) * | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| US20050261189A1 (en) * | 2004-04-16 | 2005-11-24 | Hydra Biosciences, Inc. | Methods of promoting cardiac cell proliferation |
| US8173118B2 (en) | 2004-07-30 | 2012-05-08 | Mayo Foundation For Medical Education And Research | Compositions consisting essentially of TGF-β, BMP-2 FGF-4, leukemia inhibitory factor, IGF-1, IL-6 and H-α-thrombin |
| CA2612394C (en) * | 2005-06-15 | 2017-02-21 | The Ohio State University Research Foundation | Her-2 peptides |
| US9765298B2 (en) | 2006-07-24 | 2017-09-19 | Mayo Foundation For Medical Education And Research | Methods and materials for providing cardiac cells |
| US20090042795A1 (en) * | 2007-06-05 | 2009-02-12 | Pasan Fernando | Cardiac stem cell proliferation proteins, fragments thereof and methods of modulating stem cell proliferation and differentiation |
| WO2009145761A1 (en) | 2008-05-27 | 2009-12-03 | Mayo Foundation For Medical Education And Research | Methods and materials for using cells to treat heart tissue |
| US8193161B2 (en) | 2008-06-09 | 2012-06-05 | New York Medical College | Compositions comprising cardiac stem cells overexpressing specific micrornas and methods of their use in repairing damaged myocardium |
| US20100234283A1 (en) | 2009-02-04 | 2010-09-16 | The Ohio State University Research Foundation | Immunogenic epitopes, peptidomimetics, and anti-peptide antibodies, and methods of their use |
| EP2709653B1 (de) * | 2011-04-20 | 2017-11-22 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Aav-vermittelter exendin-4-gentransfer in die speicheldrüsen zum schutz vor diabetes oder adipositas |
| US9962427B2 (en) | 2016-07-11 | 2018-05-08 | Ottawa Hospital Research Institute | Treatment of right ventricular dysfunction due to pressure overload |
| CN109943533B (zh) * | 2019-03-29 | 2021-01-01 | 上海交通大学医学院附属第九人民医院 | 一种制备脂肪干细胞外泌体的方法、脂肪干细胞外泌体及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6472585B1 (en) * | 1994-04-25 | 2002-10-29 | Genentech, Inc. | Cardiotrophin-1 defective mouse |
| US5534615A (en) * | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
| WO1995029237A1 (en) * | 1994-04-25 | 1995-11-02 | Genentech, Inc. | Cardiotrophin and uses therefor |
| US20040006018A1 (en) * | 1996-02-14 | 2004-01-08 | Genentech, Inc. | Cardiotrophin and uses therefor |
| US5851984A (en) * | 1996-08-16 | 1998-12-22 | Genentech, Inc. | Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides |
| WO1998044142A1 (en) * | 1997-04-01 | 1998-10-08 | The General Hospital Corporation | Molecular marker for muscle stem cells |
| US20030103951A1 (en) * | 1997-07-14 | 2003-06-05 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| CA2296704C (en) * | 1997-07-14 | 2010-10-19 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US20020142457A1 (en) * | 1999-12-28 | 2002-10-03 | Akihiro Umezawa | Cell having the potentiality of differentiation into cardiomyocytes |
| US7547674B2 (en) * | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US20030027330A1 (en) * | 2001-04-02 | 2003-02-06 | Robert Lanza | Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells |
| ES2200646B1 (es) * | 2001-09-21 | 2005-05-01 | Fundacion Para La Investigacion Medica Aplicada | Uso de la cardiotrofina en enfermedades hepaticas. |
| WO2010118059A1 (en) * | 2009-04-06 | 2010-10-14 | Capricor, Inc. | Systems and methods for cardiac tissue repair |
-
2004
- 2004-06-25 AT AT04737879T patent/ATE463511T1/de not_active IP Right Cessation
- 2004-06-25 AU AU2004249340A patent/AU2004249340B2/en not_active Ceased
- 2004-06-25 JP JP2006515608A patent/JP4838710B2/ja not_active Expired - Fee Related
- 2004-06-25 ES ES04737879T patent/ES2344204T3/es not_active Expired - Lifetime
- 2004-06-25 WO PCT/CA2004/000940 patent/WO2004113380A1/en not_active Ceased
- 2004-06-25 NZ NZ544828A patent/NZ544828A/en not_active IP Right Cessation
- 2004-06-25 EP EP04737879A patent/EP1639003B1/de not_active Expired - Lifetime
- 2004-06-25 CA CA002570464A patent/CA2570464A1/en not_active Abandoned
- 2004-06-25 CN CNA2004800178899A patent/CN1812996A/zh active Pending
- 2004-06-25 DE DE602004026445T patent/DE602004026445D1/de not_active Expired - Lifetime
-
2005
- 2005-12-22 US US11/318,413 patent/US20060115464A1/en not_active Abandoned
-
2015
- 2015-12-01 US US14/956,177 patent/US20160222352A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004026445D1 (de) | 2010-05-20 |
| CN1812996A (zh) | 2006-08-02 |
| US20060115464A1 (en) | 2006-06-01 |
| CA2570464A1 (en) | 2004-12-29 |
| JP2007537692A (ja) | 2007-12-27 |
| ES2344204T3 (es) | 2010-08-20 |
| AU2004249340A1 (en) | 2004-12-29 |
| US20160222352A1 (en) | 2016-08-04 |
| EP1639003B1 (de) | 2010-04-07 |
| AU2004249340B2 (en) | 2011-04-21 |
| JP4838710B2 (ja) | 2011-12-14 |
| NZ544828A (en) | 2008-10-31 |
| EP1639003A1 (de) | 2006-03-29 |
| WO2004113380A1 (en) | 2004-12-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE463511T1 (de) | Verwendung von cardiotrophin zur modulation der stammzellenproliferation | |
| DE60238058D1 (de) | Verwendung von lysyloxydase inhibitoren zur zellkultur und gewebeaufbau | |
| GB2436737B (en) | Culture medium containing kinase inhibitors,and uses thereof | |
| ATE474052T1 (de) | Verfahren zur herstellung von rekombinanten proteinen mittels inhibitoren von apoptose | |
| WO2004113513A3 (en) | Methods and compositions for modulating stem cell growth and differentiation | |
| ATE549395T1 (de) | Medium und kultur von embryonalen stammzellen | |
| ATE517996T1 (de) | Verfahren und mittel zur erhöhung der toleranz von pflanzen gegenüber stressbedingungen | |
| ATE485065T1 (de) | Gewebekonstruktionsvorrichtungen zur reparatur und regeneration von gewebe | |
| DE602004019542D1 (de) | Proteasome inhibitoren und deren verwendung | |
| NO20001583D0 (no) | Stimulering av hematopoetiske celler in vitro | |
| MX2007001772A (es) | Composiciones y metodos para auto-renovacion y diferenciacion de celulas troncales embrionicas humanas. | |
| MX345394B (es) | Modulacion de la diferenciacion de celulas madre y progenitoras, ensayos y usos de las mismas. | |
| DK1019490T3 (da) | Fremgangsmåder til modulering af hæmatopoese og vaskulær vækst | |
| DE602004008453D1 (de) | Künstliches immunorgan | |
| CR9586A (es) | Metodos para modular el desarrollo osteocondral utilizando una terapia de campo electromagnetico con impulsos | |
| ATE382060T1 (de) | Moleküle und verfahren zur inhibierung der freisetzung von kim-1 | |
| ATE480615T1 (de) | Verfahren zur proliferation von stammzellen | |
| ATE248592T1 (de) | Verwendung von naaladase hemmern zur herstellung eines medikaments zur behandlung von bestimmten krankheiten | |
| ATE542536T1 (de) | 3-ä4-(dibenzoäb,füä1,4üoxazepin-11-yl)-piperazi - 1-ylü-2,2-dimethyl propansäure zur verwendung in der behandlung von schlafstörungen | |
| ATE421574T1 (de) | Zellkulturmethode zur erzeugung von prostata- ähnlichen acini | |
| ATE445402T1 (de) | Neue verwendung von pde5-hemmern | |
| DE69624918D1 (de) | Verwendung von pseudopterosin zur förderung der wundheilung | |
| ATE478156T1 (de) | Verfahren zur identifizierung von modulatoren der eoxin-bildung | |
| DE602005021681D1 (de) | Stibogluconate-natrium und il-2 zur krebsbehandlung | |
| AR059193A1 (es) | Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |