ATE455790T1 - Inhibitoren von proteinen der rho-gef-familie - Google Patents

Inhibitoren von proteinen der rho-gef-familie

Info

Publication number
ATE455790T1
ATE455790T1 AT03755132T AT03755132T ATE455790T1 AT E455790 T1 ATE455790 T1 AT E455790T1 AT 03755132 T AT03755132 T AT 03755132T AT 03755132 T AT03755132 T AT 03755132T AT E455790 T1 ATE455790 T1 AT E455790T1
Authority
AT
Austria
Prior art keywords
rho
protein
gef
proteins
peptide
Prior art date
Application number
AT03755132T
Other languages
English (en)
Inventor
Anne Debant
Susanne Schmidt
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE455790T1 publication Critical patent/ATE455790T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT03755132T 2002-05-29 2003-05-26 Inhibitoren von proteinen der rho-gef-familie ATE455790T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02291312A EP1367064A1 (de) 2002-05-29 2002-05-29 Inhibitoren von Proteinen der Rho-GEF-Familie
PCT/EP2003/005485 WO2003099778A2 (en) 2002-05-29 2003-05-26 Inhibitors of proteins from the rho-gef family

Publications (1)

Publication Number Publication Date
ATE455790T1 true ATE455790T1 (de) 2010-02-15

Family

ID=29414828

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03755132T ATE455790T1 (de) 2002-05-29 2003-05-26 Inhibitoren von proteinen der rho-gef-familie

Country Status (7)

Country Link
US (2) US20060210973A1 (de)
EP (2) EP1367064A1 (de)
AT (1) ATE455790T1 (de)
AU (1) AU2003242574A1 (de)
DE (1) DE60331058D1 (de)
ES (1) ES2341171T3 (de)
WO (1) WO2003099778A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013507950A (ja) * 2009-10-22 2013-03-07 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィク グアニン交換因子インヒビター及び抗癌剤としてのその使用
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292646A (en) * 1991-02-06 1994-03-08 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
AU2555697A (en) * 1996-03-27 1997-10-17 Dana-Farber Cancer Institute Novel trio molecules and uses related thereto
US6238881B1 (en) * 1996-11-06 2001-05-29 Onyx Pharmaceuticals, Inc. Nucleic acids and polypeptides related to a guanine exchange factor of Rho GTPase
WO2002026817A2 (en) * 2000-09-25 2002-04-04 Millennium Pharmaceuticals, Inc. 33521, a human guanine nucleotide exchange family member and uses thereof

Also Published As

Publication number Publication date
AU2003242574A8 (en) 2003-12-12
US20060210973A1 (en) 2006-09-21
US20090036379A1 (en) 2009-02-05
EP1507797A2 (de) 2005-02-23
WO2003099778A2 (en) 2003-12-04
AU2003242574A1 (en) 2003-12-12
WO2003099778A3 (en) 2004-09-16
DE60331058D1 (de) 2010-03-11
ES2341171T3 (es) 2010-06-16
US8088892B2 (en) 2012-01-03
EP1367064A1 (de) 2003-12-03
EP1507797B1 (de) 2010-01-20

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Legal Events

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