ATE448218T1 - CHEMICAL PROCESS - Google Patents

CHEMICAL PROCESS

Info

Publication number
ATE448218T1
ATE448218T1 AT06794582T AT06794582T ATE448218T1 AT E448218 T1 ATE448218 T1 AT E448218T1 AT 06794582 T AT06794582 T AT 06794582T AT 06794582 T AT06794582 T AT 06794582T AT E448218 T1 ATE448218 T1 AT E448218T1
Authority
AT
Austria
Prior art keywords
chemical process
chemical
Prior art date
Application number
AT06794582T
Other languages
German (de)
Inventor
Joergen Blixt
Michael Golden
Philip Hogan
David Martin
Francis Montgomery
Zakariya Patel
John Pittam
George Sependa
Christopher Squire
Nicholas Wright
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35395001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE448218(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE448218T1 publication Critical patent/ATE448218T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06794582T 2005-09-30 2006-09-27 CHEMICAL PROCESS ATE448218T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0519879.1A GB0519879D0 (en) 2005-09-30 2005-09-30 Chemical process
PCT/GB2006/003587 WO2007036713A2 (en) 2005-09-30 2006-09-27 Chemical process

Publications (1)

Publication Number Publication Date
ATE448218T1 true ATE448218T1 (en) 2009-11-15

Family

ID=35395001

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06794582T ATE448218T1 (en) 2005-09-30 2006-09-27 CHEMICAL PROCESS
AT09152654T ATE481399T1 (en) 2005-09-30 2006-09-27 METHOD FOR IN-SITU CHEMICAL SULFONATION

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT09152654T ATE481399T1 (en) 2005-09-30 2006-09-27 METHOD FOR IN-SITU CHEMICAL SULFONATION

Country Status (32)

Country Link
US (8) US8163926B2 (en)
EP (2) EP2053048B8 (en)
JP (2) JP5213715B2 (en)
KR (1) KR101307641B1 (en)
CN (3) CN101277948B (en)
AR (1) AR055671A1 (en)
AT (2) ATE448218T1 (en)
AU (1) AU2006296367B2 (en)
BR (1) BRPI0616715A2 (en)
CA (2) CA2624045C (en)
CY (2) CY1110275T1 (en)
DE (2) DE602006017004D1 (en)
DK (2) DK2053048T3 (en)
ES (2) ES2350513T3 (en)
GB (1) GB0519879D0 (en)
HK (2) HK1122553A1 (en)
HR (2) HRP20100019T1 (en)
IL (2) IL190172A (en)
ME (2) ME01466B (en)
MY (2) MY145540A (en)
NO (1) NO342152B1 (en)
NZ (2) NZ566566A (en)
PL (2) PL1943240T3 (en)
PT (2) PT2053048E (en)
RS (2) RS51515B (en)
RU (1) RU2448102C2 (en)
SG (1) SG165416A1 (en)
SI (2) SI1943240T1 (en)
TW (2) TWI424991B (en)
UY (1) UY29824A1 (en)
WO (1) WO2007036713A2 (en)
ZA (1) ZA200802416B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1474420B1 (en) * 2002-02-01 2012-03-14 AstraZeneca AB Quinazoline compounds
GB0519879D0 (en) * 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
US7851623B2 (en) * 2006-11-02 2010-12-14 Astrazeneca Ab Chemical process
EP2404595B1 (en) * 2011-09-01 2015-08-05 Symrise AG Method for manufacturing indanone derivatives
WO2014027045A1 (en) * 2012-08-15 2014-02-20 Glaxo Group Limited Chemical process
CN104098544A (en) * 2013-04-07 2014-10-15 浙江九洲药物科技有限公司 Preparation method of vandetanib
CN106397401B (en) * 2016-08-30 2018-11-13 山东罗欣药业集团股份有限公司 A kind of crystalline compounds of anticancer drug and preparation method thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870083A (en) * 1987-11-24 1989-09-26 Merrell Dow Pharmaceuticals Inc. 1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants
JP2829744B2 (en) 1989-05-31 1998-12-02 川研ファインケミカル株式会社 Method for producing piperidine carboxylic acids
WO1992006086A1 (en) 1990-10-01 1992-04-16 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
CZ289756B6 (en) 1991-03-28 2002-04-17 Eisai Co., Ltd. Heterocyclic-cyclic amine derivatives, intermediates for preparing these compounds, a pharmaceutical preparation as well as use of said derivatives
SG64322A1 (en) 1991-05-10 1999-04-27 Rhone Poulenc Rorer Int Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
CA2118117A1 (en) 1993-02-18 1994-08-19 Shigeki Fujiwara Adenosine uptake inhibitor
EP0700383B1 (en) * 1993-05-26 1998-09-23 Syntex (U.S.A.) Inc. Novel 1-phenylalkanone 5-ht 4? receptor ligands
DE4326344A1 (en) 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamides, pharmaceutical compositions containing these compounds and process for their preparation
AU685212B2 (en) * 1994-01-13 1998-01-15 Merck Sharp & Dohme Limited Gem-disubstituted azacyclic tachykinin antagonists
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
ATE211134T1 (en) 1996-03-05 2002-01-15 4-ANILINOQUINAZOLINE DERIVATIVES
EP0954315A2 (en) 1996-09-13 1999-11-10 Sugen, Inc. Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
MXPA02004366A (en) * 1999-11-05 2002-11-07 Astrazeneca Ab Quinazoline derivatives as vegf inhibitors.
GB0126879D0 (en) 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
CA2470044C (en) 2001-12-20 2010-12-14 Osi Pharmaceuticals, Inc. Pyrrolopyrimidine a2b selective antagonist compounds, their synthesis and use
EP1474420B1 (en) 2002-02-01 2012-03-14 AstraZeneca AB Quinazoline compounds
WO2003066602A1 (en) 2002-02-06 2003-08-14 Ube Industries, Ltd. Process for producing 4-aminoquinazoline compound
KR20050056190A (en) 2002-08-09 2005-06-14 아스트라제네카 아베 Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer
GB0218526D0 (en) 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
DK1592423T3 (en) 2003-02-13 2011-06-27 Astrazeneca Ab Combination therapy of ZD6474 with 5-FU and / or CPT-11
MXPA06000114A (en) 2003-07-10 2006-04-27 Astrazeneca Ab Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability.
GB0318423D0 (en) 2003-08-06 2003-09-10 Astrazeneca Ab Chemical compounds
GB0519879D0 (en) * 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process

Also Published As

Publication number Publication date
PT2053048E (en) 2010-11-10
CN101277948B (en) 2013-03-13
ES2350513T3 (en) 2011-01-24
CA2624045A1 (en) 2007-04-05
US20190263782A1 (en) 2019-08-29
KR20080049114A (en) 2008-06-03
SG165416A1 (en) 2010-10-28
JP5654546B2 (en) 2015-01-14
SI2053048T1 (en) 2010-12-31
US20240150317A1 (en) 2024-05-09
NZ593930A (en) 2013-02-22
US20160185754A1 (en) 2016-06-30
IL190172A (en) 2014-05-28
KR101307641B1 (en) 2013-09-12
NZ566566A (en) 2011-08-26
ES2335435T3 (en) 2010-03-26
IL227574A (en) 2015-08-31
RU2008116573A (en) 2009-11-10
CN102503898A (en) 2012-06-20
CA2745829C (en) 2013-07-02
HK1122553A1 (en) 2009-05-22
US20120095229A1 (en) 2012-04-19
MY149834A (en) 2013-10-31
US20140378684A1 (en) 2014-12-25
SI1943240T1 (en) 2010-02-26
CN102503933A (en) 2012-06-20
DE602006010428D1 (en) 2009-12-24
US20220033377A1 (en) 2022-02-03
CN102503933B (en) 2014-06-25
TWI328580B (en) 2010-08-11
CA2624045C (en) 2012-05-22
JP2009510039A (en) 2009-03-12
AR055671A1 (en) 2007-08-29
UY29824A1 (en) 2007-04-30
TW200745036A (en) 2007-12-16
EP2053048A1 (en) 2009-04-29
CA2745829A1 (en) 2007-04-05
RS51515B (en) 2011-06-30
PL1943240T3 (en) 2010-04-30
CY1110887T1 (en) 2015-06-10
US8865899B2 (en) 2014-10-21
EP2053048B8 (en) 2011-09-21
DK2053048T3 (en) 2010-11-29
TW201018660A (en) 2010-05-16
ME01531B (en) 2014-04-20
PT1943240E (en) 2010-01-11
US10344015B2 (en) 2019-07-09
DK1943240T3 (en) 2010-03-01
JP5213715B2 (en) 2013-06-19
EP1943240A2 (en) 2008-07-16
MY145540A (en) 2012-02-29
WO2007036713A3 (en) 2007-06-14
NO342152B1 (en) 2018-04-03
BRPI0616715A2 (en) 2011-06-28
DE602006017004D1 (en) 2010-10-28
AU2006296367B2 (en) 2011-08-11
US8163926B2 (en) 2012-04-24
ZA200802416B (en) 2009-01-28
ATE481399T1 (en) 2010-10-15
PL2053048T3 (en) 2011-03-31
US9815816B2 (en) 2017-11-14
RU2448102C2 (en) 2012-04-20
ME01466B (en) 2014-04-20
NO20081267L (en) 2008-04-30
HRP20100019T1 (en) 2010-02-28
EP1943240B1 (en) 2009-11-11
CY1110275T1 (en) 2015-01-14
IL190172A0 (en) 2008-08-07
HRP20100620T1 (en) 2010-12-31
CN102503898B (en) 2015-03-25
RS51263B (en) 2010-12-31
US20090203905A1 (en) 2009-08-13
US20180118716A1 (en) 2018-05-03
TWI424991B (en) 2014-02-01
EP2053048B1 (en) 2010-09-15
JP2013063998A (en) 2013-04-11
AU2006296367A1 (en) 2007-04-05
WO2007036713A2 (en) 2007-04-05
GB0519879D0 (en) 2005-11-09
HK1130478A1 (en) 2009-12-31
CN101277948A (en) 2008-10-01

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