ATE445596T1 - METHOD FOR PRODUCING INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF EZETIMIBE - Google Patents

METHOD FOR PRODUCING INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF EZETIMIBE

Info

Publication number
ATE445596T1
ATE445596T1 AT06850451T AT06850451T ATE445596T1 AT E445596 T1 ATE445596 T1 AT E445596T1 AT 06850451 T AT06850451 T AT 06850451T AT 06850451 T AT06850451 T AT 06850451T AT E445596 T1 ATE445596 T1 AT E445596T1
Authority
AT
Austria
Prior art keywords
ezetimibe
production
intermediate products
producing intermediate
producing
Prior art date
Application number
AT06850451T
Other languages
German (de)
Inventor
I Escude Ana Gavalda
I Llado Jordi Bosch
I Ferran Anton Vidal
Garcia Eva Garcia
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Application granted granted Critical
Publication of ATE445596T1 publication Critical patent/ATE445596T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT06850451T 2005-12-22 2006-12-22 METHOD FOR PRODUCING INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF EZETIMIBE ATE445596T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75258905P 2005-12-22 2005-12-22
PCT/IB2006/004107 WO2007119106A2 (en) 2005-12-22 2006-12-22 Processes for preparing intermediate compounds useful for the preparation of ezetimibe

Publications (1)

Publication Number Publication Date
ATE445596T1 true ATE445596T1 (en) 2009-10-15

Family

ID=38609864

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06850451T ATE445596T1 (en) 2005-12-22 2006-12-22 METHOD FOR PRODUCING INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF EZETIMIBE

Country Status (8)

Country Link
US (1) US20090227786A1 (en)
EP (1) EP1971573B1 (en)
AR (1) AR058754A1 (en)
AT (1) ATE445596T1 (en)
CA (1) CA2634648A1 (en)
DE (1) DE602006009845D1 (en)
IL (1) IL192362A0 (en)
WO (1) WO2007119106A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1893570A4 (en) * 2005-06-22 2009-12-23 Reddy Manne Satynarayana Improved process for the preparation of ezetimibe
US20070259845A1 (en) * 2005-09-08 2007-11-08 Kansal Vinod K Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe
HUP0501164A2 (en) * 2005-12-20 2007-07-30 Richter Gedeon Nyrt New industrial process for the production of ezetimibe
EP2007718A2 (en) * 2006-03-29 2008-12-31 Medichem, S.A. Processes for preparing ezetimibe and intermediate compounds useful for the preparation thereof
US20080032964A1 (en) * 2006-04-10 2008-02-07 Kansal Vinod K Process for the synthesis of azetidinone
BRPI0706041A2 (en) * 2006-08-29 2011-03-22 Teva Pharmaceutichal Ind Ltd (3r, 4s) -4- (phenyl-4-hydroxy-protected) -1- (4-fluorophenyl) -3- [3- (4-fluorophenyl) -3-oxoprophyl] azetidine-2-one processes for purification
CZ302395B6 (en) * 2007-03-02 2011-04-27 Zentiva, A. S. Process for preparing (3R,4S)-l-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3- hydroxypropyl)]-4-(4-hydroxyphenyl)-2-azetidinone
US8013189B2 (en) 2007-09-21 2011-09-06 Basf Se Accelerated amide and ester reductions with amine boranes and additives
CZ2007843A3 (en) * 2007-11-30 2009-06-10 Zentiva, A. S. Process for preparing (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl)]-4-(4-hydroxyphenyl)-2-azetidinone and intermediates thereof
CZ305066B6 (en) * 2008-02-25 2015-04-22 Zentiva, K.S. Process for preparing (3R, 4S)-l-(4-fiuorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3- hydroxypropyl)]-4-(4-hydroxyphenyl)-2-azetidinone
WO2010113182A1 (en) * 2009-03-31 2010-10-07 Lupin Limited Intermediates in the preparation of 1,4-diphenyl azetidinone
WO2010113175A2 (en) 2009-04-01 2010-10-07 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
US9040262B2 (en) 2010-05-04 2015-05-26 Codexis, Inc. Biocatalysts for ezetimibe synthesis
ES2372460B1 (en) 2010-07-09 2012-11-16 Moehs Ibérica S.L. NEW METHOD FOR THE PREPARATION OF EZETIMIBA.
WO2012076030A1 (en) * 2010-12-10 2012-06-14 Pharmathen S.A. Process for the preparation of intermediate compounds useful in the preparation of ezetimibe
CN102731489B (en) * 2011-04-11 2016-10-26 天津药物研究院有限公司 A kind of preparation method of key ezetimibe intermediate
CN103159751A (en) * 2011-12-13 2013-06-19 重庆华邦胜凯制药有限公司 A preparation method for the derivates of phenylpyruvic acid amide ketals
CN104744331B (en) * 2013-12-31 2018-05-15 浙江九洲药业股份有限公司 A kind of synthesis technique of Ezetimible intermediate
CN104447473B (en) * 2014-11-06 2016-11-16 成都森科制药有限公司 The preparation method of Ezetimibe intermediate
CN105439929B (en) * 2015-12-16 2018-08-21 江苏恒盛药业有限公司 A kind of synthesis technology of ezetimibe intermediate
CN107652214A (en) * 2017-11-07 2018-02-02 河南师范大学 A kind of preparation method of high fat of blood curative Ezetimibe
CN107793339A (en) * 2017-11-07 2018-03-13 河南师范大学 A kind of preparation method of high fat of blood curative Ezetimibe
CN107903200A (en) * 2017-11-07 2018-04-13 河南师范大学 A kind of preparation method of hyperlipidemia curative Ezetimibe
CN107991410A (en) * 2017-11-24 2018-05-04 中山奕安泰医药科技有限公司 Detection method of ezetimibe intermediate
TR2022019472A1 (en) * 2022-12-16 2024-07-22 Izmir Yueksek Teknoloji Enstituesue Rektoerluegue USE OF EZETİMIB AND ITS SYNTHESIS INTERMEDIATES AND İZOPAZOPANIB STRUCTURED MOLECULES AS ANTI-CANCER AGENT
CN116283948A (en) * 2023-02-24 2023-06-23 江苏阿尔法药业股份有限公司 Synthesis method of ezetimibe intermediate
WO2025238757A1 (en) * 2024-05-15 2025-11-20 Ｎｔｔ株式会社 Secondary battery
WO2025238768A1 (en) * 2024-05-15 2025-11-20 Ｎｔｔ株式会社 Lithium secondary battery

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
AU7472896A (en) * 1995-11-02 1997-05-22 Schering Corporation Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-({phenyl or 4-fluorophenyl})-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinon
US5886171A (en) * 1996-05-31 1999-03-23 Schering Corporation 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones
US5739321A (en) * 1996-05-31 1998-04-14 Schering Corporation 3-hydroxy γ-lactone based enantionselective synthesis of azetidinones
EP1893570A4 (en) * 2005-06-22 2009-12-23 Reddy Manne Satynarayana Improved process for the preparation of ezetimibe
US20070259845A1 (en) * 2005-09-08 2007-11-08 Kansal Vinod K Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe
HUP0501164A2 (en) * 2005-12-20 2007-07-30 Richter Gedeon Nyrt New industrial process for the production of ezetimibe
EP2007718A2 (en) * 2006-03-29 2008-12-31 Medichem, S.A. Processes for preparing ezetimibe and intermediate compounds useful for the preparation thereof
US20080032964A1 (en) * 2006-04-10 2008-02-07 Kansal Vinod K Process for the synthesis of azetidinone
BRPI0706041A2 (en) * 2006-08-29 2011-03-22 Teva Pharmaceutichal Ind Ltd (3r, 4s) -4- (phenyl-4-hydroxy-protected) -1- (4-fluorophenyl) -3- [3- (4-fluorophenyl) -3-oxoprophyl] azetidine-2-one processes for purification
US20090047716A1 (en) * 2007-06-07 2009-02-19 Nurit Perlman Reduction processes for the preparation of ezetimibe
US20080318920A1 (en) * 2007-06-19 2008-12-25 Protia, Llc Deuterium-enriched ezetimibe
WO2009032264A1 (en) * 2007-08-30 2009-03-12 Teva Pharmaceutical Industries Ltd. Processes for preparing intermediates of ezetimibe by microbial reduction
CZ305066B6 (en) * 2008-02-25 2015-04-22 Zentiva, K.S. Process for preparing (3R, 4S)-l-(4-fiuorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3- hydroxypropyl)]-4-(4-hydroxyphenyl)-2-azetidinone

Also Published As

Publication number Publication date
DE602006009845D1 (en) 2009-11-26
WO2007119106A2 (en) 2007-10-25
AR058754A1 (en) 2008-02-20
EP1971573B1 (en) 2009-10-14
EP1971573A2 (en) 2008-09-24
IL192362A0 (en) 2009-08-03
US20090227786A1 (en) 2009-09-10
CA2634648A1 (en) 2007-10-25
WO2007119106A3 (en) 2008-01-31

Similar Documents

Publication Publication Date Title
ATE445596T1 (en) METHOD FOR PRODUCING INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF EZETIMIBE
DE602007013512D1 (en) Process for the continuous production of components
EP2038375A4 (en) PROCESS FOR THE PRODUCTION OF BASE OILS
DE602004023921D1 (en) NEW PROCESS FOR THE PRODUCTION OF ROLUMUMILAST
ATE408604T1 (en) METHOD FOR PRODUCING 1-ALKYL-3-PHENYLURACILENE
EP2073636A4 (en) PROCESS FOR THE PREPARATION OF OXYMORPHONE
DE602004029247D1 (en) PROCESS FOR THE PRODUCTION OF OLEFINOXIDE
DE602006014558D1 (en) IMPROVED PROCESS FOR THE PRODUCTION OF TEA
DE602006018429D1 (en) PROCESS FOR PRODUCING CLOSURES
EP1916302A4 (en) PROCESS FOR THE PRODUCTION OF LYMPHOCYTES
ATE406801T1 (en) METHOD FOR PRODUCING SOUR MILK PRODUCTS
DE502006001281D1 (en) PROCESS FOR PRODUCING SUBSTITUTED BIPHENYLES
ATE404070T1 (en) METHOD FOR PRODUCING CHOCOLATE GRANULES BASE MATERIAL FOR CHOCOLATE PRODUCTION
DE602005019454D1 (en) METHOD FOR THE PRODUCTION OF ALOE-EMODIN
DE502005007762D1 (en) METHOD FOR THE PRODUCTION OF GEARS
ATE522522T1 (en) METHOD FOR PRODUCING COMPOUNDS USEFUL AS INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
DE502006006803D1 (en) METHOD FOR THE PRODUCTION OF LEATHER
DE502004011882D1 (en) METHOD FOR THE PRODUCTION OF CELLULOSIC FORM BODIES
DE112009000076A5 (en) Process for the production of urethanes
DE502005000987D1 (en) PROCESS FOR CONTINUOUS PRODUCTION OF SIILICONE EMULSIONS
ATE384046T1 (en) ASYMMETRIC HYDROGENATION PROCESS SUITABLE FOR THE PRODUCTION OF CYCLOALKANINDOLE DERIVATIVES
DE50305250D1 (en) Process for the production of polyurethane moldings
ATE444303T1 (en) METHOD FOR PRODUCING FERRISUCCINYLCASEIN
DE502004012038D1 (en) Process for the production of polyurethane moldings
DE602005004221D1 (en) Process for the production of shaped fiber bodies

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties