ATE437878T1 - Metallchelate von makrocyclischen polyaminocarbonsäurederivaten und deren anwendung bei der diagnostischen bilderzeugung - Google Patents
Metallchelate von makrocyclischen polyaminocarbonsäurederivaten und deren anwendung bei der diagnostischen bilderzeugungInfo
- Publication number
- ATE437878T1 ATE437878T1 AT06725304T AT06725304T ATE437878T1 AT E437878 T1 ATE437878 T1 AT E437878T1 AT 06725304 T AT06725304 T AT 06725304T AT 06725304 T AT06725304 T AT 06725304T AT E437878 T1 ATE437878 T1 AT E437878T1
- Authority
- AT
- Austria
- Prior art keywords
- diagnostic imaging
- polyaminocarbonic
- macrocyclic
- application
- acid derivatives
- Prior art date
Links
- 238000002059 diagnostic imaging Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 239000002184 metal Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000013522 chelant Substances 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
- A61K49/1854—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly(meth)acrylate, polyacrylamide, polyvinylpyrrolidone, polyvinylalcohol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Nanotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0502921A FR2883562B1 (fr) | 2005-03-24 | 2005-03-24 | Chelates lipophiles et leur utilisation en imagerie |
| PCT/EP2006/061034 WO2006100305A2 (fr) | 2005-03-24 | 2006-03-24 | Chelates métalliques de dérivés macrocycliques polyaminocarboxyliques et leur utilisation en imagerie diagnostique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE437878T1 true ATE437878T1 (de) | 2009-08-15 |
Family
ID=35311843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06725304T ATE437878T1 (de) | 2005-03-24 | 2006-03-24 | Metallchelate von makrocyclischen polyaminocarbonsäurederivaten und deren anwendung bei der diagnostischen bilderzeugung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8268810B2 (de) |
| EP (1) | EP1885721B1 (de) |
| AT (1) | ATE437878T1 (de) |
| DE (1) | DE602006008135D1 (de) |
| ES (1) | ES2330140T3 (de) |
| FR (1) | FR2883562B1 (de) |
| WO (1) | WO2006100305A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1940841B9 (de) * | 2005-10-07 | 2017-04-19 | Guerbet | Verbindungen mit einem eine biologische zielstruktur erkennenden teil, das mit einem zum komplexieren von gallium fähigen signalteil gekoppelt ist |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| FR2906806B1 (fr) | 2006-10-09 | 2012-12-14 | Centre Nat Rech Scient | Complexes chelates dendritiques, leurs procedes de fabrication et compositions pharmaceutiques les contenant |
| FR2914304B1 (fr) | 2007-03-28 | 2012-11-16 | Guerbet Sa | Composes pour le diagnostic de maladies liees a l'expression de vcam. |
| FR2914303A1 (fr) * | 2007-03-28 | 2008-10-03 | Guerbet Sa | Composes pour le diagnostic de l'apoptose. |
| EP2067490A1 (de) * | 2007-12-07 | 2009-06-10 | Koninklijke Philips Electronics N.V. | Chelatbildnerderivate und diese enthaltende Zusammensetzungen zur Verwendung bei Bildgebungsverfahren |
| FR2939318B1 (fr) * | 2008-12-10 | 2012-07-13 | Guerbet Sa | Systeme d'encapsulation pour imagerie cest avec quelate q superieur ou egal a 2 |
| FR2968999B1 (fr) * | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
| FR2980365B1 (fr) * | 2011-09-26 | 2016-02-12 | Guerbet Sa | Nanoemulsions, leur procede de preparation, et leur utilisation comme agent de contraste. |
| FR2980364B1 (fr) * | 2011-09-26 | 2018-08-31 | Guerbet | Nanoemulsions et leur utilisation comme agents de contraste |
| ES2726603T3 (es) * | 2012-09-07 | 2019-10-08 | Bracco Imaging Spa | Nanopartículas lipídicas sólidas paramagnéticas (pSLN) que contienen complejos anfifílicos metálicos para IRM |
| US10568976B2 (en) | 2015-11-26 | 2020-02-25 | Debreceni Egyetem | 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca-1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents |
| WO2017089849A1 (en) | 2015-11-26 | 2017-06-01 | Debreceni Egyetem | New 6-oxa-3,9, 15-triaza-bicyclo[9.3.1 ]pentadec a- 1 ( 14), 1 1 ( 15), 12-triene derivatives based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents |
| EP3380473A1 (de) | 2015-11-26 | 2018-10-03 | Debreceni Egyetem | Neue 2,1-l-diaza-[3.3](2,6)pyridinophan-verbindungen und deren anwendung als liganden von auf essentiellen metallionen basierenden mrt-kontrastmitteln und 52mn-basierenden pet-kontrastmitteln |
| WO2020023092A2 (en) * | 2018-04-25 | 2020-01-30 | The Johns Hopkins University | Alpha particle formulations for treatment of solid tumors |
| BR112021001102B1 (pt) * | 2018-08-06 | 2022-12-20 | Bracco Imaging Spa | Misturas isoméricas de um derivado de amida de gd(pcta - ácido tris-glutárico) e composições farmacêuticas |
| IL308731A (en) * | 2021-05-21 | 2024-01-01 | Northstar Medical Tech Llc | UROKINASE PLASMINOGEN RECEPTOR TARGETED RADIOPHARMACEUTICALS |
| CN114105983B (zh) * | 2021-11-09 | 2023-08-11 | 国科温州研究院(温州生物材料与工程研究所) | 手性1,4,7,10-四氮杂-2,6-吡啶环蕃衍生物及其金属螯合物的制备和应用 |
| WO2024116053A1 (en) * | 2022-11-28 | 2024-06-06 | Novartis Ag | Pcta derivatives, conjugates thereof and uses thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242681A (en) | 1990-03-12 | 1993-09-07 | Research Corporation Technologies, Inc. | Lipophilic contrast agents for diagnostic image analysis |
| US5154914A (en) | 1990-03-12 | 1992-10-13 | Research Corporation Technologies, Inc. | Methods of diagnostic image analysis using lipophilic contrast agents |
| CA2102605A1 (en) | 1991-05-23 | 1992-11-24 | Evan C. Unger | Liposoluble compounds for magnetic resonance imaging |
| US6875864B2 (en) | 1991-08-01 | 2005-04-05 | Bracco International B.V. | Aminocarboxylate ligands having substituted aromatic amide moieties |
| ZA929575B (en) | 1991-12-10 | 1994-06-10 | Dow Chemical Co | Bicyclopolyazamacrocyclocarboxyclic acid complexes,their conjugates,processes for their preparation,and use as contrast agents |
| WO1994026315A1 (en) * | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals |
| US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US5614170A (en) | 1994-11-30 | 1997-03-25 | Hemagen/Pfc | Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI) |
| US5958371A (en) | 1995-06-08 | 1999-09-28 | Barnes-Jewish Hospital | Site specific binding system, nuclear imaging compositions and methods |
| US5833948A (en) | 1995-06-15 | 1998-11-10 | Bracco Research S.A. | Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant |
| IT1283218B1 (it) | 1996-03-08 | 1998-04-16 | Bracco Spa | Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi |
| US5804164A (en) | 1996-03-13 | 1998-09-08 | Research Corporation Technologies, Inc. | Water-soluble lipophilic contrast agents |
| FR2794744B1 (fr) | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| US6517814B2 (en) | 2001-01-09 | 2003-02-11 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants useful for metallopharmaceuticals |
| US6776977B2 (en) | 2001-01-09 | 2004-08-17 | Bristol-Myers Squibb Pharma Company | Polypodal chelants for metallopharmaceuticals |
| US7179449B2 (en) | 2001-01-30 | 2007-02-20 | Barnes-Jewish Hospital | Enhanced ultrasound detection with temperature-dependent contrast agents |
| ITMI20011518A1 (it) | 2001-07-17 | 2003-01-17 | Bracco Imaging Spa | Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia |
| CN101249269A (zh) | 2002-01-24 | 2008-08-27 | 巴内斯－朱威胥医院 | 整联蛋白靶向的影像剂 |
| US7279150B2 (en) | 2002-01-24 | 2007-10-09 | Barnes-Jewish Hospital | Chelating agents with lipophilic carriers |
| FR2836916B1 (fr) * | 2002-03-05 | 2004-06-11 | Guerbet Sa | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
| WO2004087656A1 (de) | 2003-04-03 | 2004-10-14 | Schering Aktiengesellschaft | Konjugate 2,4-ethano- und 2,4-propano-überbrückter 3,6,9-triaza-nonansäure-3n, 6n, 9,9n-tetraessigsäure- und entsprechender phosphorsäuremethylen-derivate und deren abkömmlinge mit biomolekülen, verfahren zu deren herstellung und deren verwendung zur herstellung |
| FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
-
2005
- 2005-03-24 FR FR0502921A patent/FR2883562B1/fr not_active Expired - Fee Related
-
2006
- 2006-03-24 ES ES06725304T patent/ES2330140T3/es active Active
- 2006-03-24 DE DE602006008135T patent/DE602006008135D1/de active Active
- 2006-03-24 AT AT06725304T patent/ATE437878T1/de not_active IP Right Cessation
- 2006-03-24 US US11/886,911 patent/US8268810B2/en active Active
- 2006-03-24 WO PCT/EP2006/061034 patent/WO2006100305A2/fr active Application Filing
- 2006-03-24 EP EP06725304A patent/EP1885721B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006008135D1 (de) | 2009-09-10 |
| WO2006100305A2 (fr) | 2006-09-28 |
| FR2883562A1 (fr) | 2006-09-29 |
| ES2330140T3 (es) | 2009-12-04 |
| US8268810B2 (en) | 2012-09-18 |
| FR2883562B1 (fr) | 2009-02-27 |
| US20090214441A1 (en) | 2009-08-27 |
| WO2006100305A3 (fr) | 2006-11-09 |
| EP1885721B1 (de) | 2009-07-29 |
| EP1885721A2 (de) | 2008-02-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |