ATE434041T1 - Bestimmung humanes cytochrom p450 3a4 (cyp3a4) - Google Patents

Bestimmung humanes cytochrom p450 3a4 (cyp3a4)

Info

Publication number
ATE434041T1
ATE434041T1 AT00955297T AT00955297T ATE434041T1 AT E434041 T1 ATE434041 T1 AT E434041T1 AT 00955297 T AT00955297 T AT 00955297T AT 00955297 T AT00955297 T AT 00955297T AT E434041 T1 ATE434041 T1 AT E434041T1
Authority
AT
Austria
Prior art keywords
cyp2c8
mabs
human cytochrome
cyp3a4
cyp2c9
Prior art date
Application number
AT00955297T
Other languages
English (en)
Inventor
Qin Mei
Thomas Rushmore
Magang Shou
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE434041T1 publication Critical patent/ATE434041T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/80—Cytochromes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT00955297T 1999-08-05 2000-08-01 Bestimmung humanes cytochrom p450 3a4 (cyp3a4) ATE434041T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14731599P 1999-08-05 1999-08-05
US15363899P 1999-09-13 1999-09-13
PCT/US2000/020864 WO2001011035A1 (en) 1999-08-05 2000-08-01 Monoclonal antibodies for human cytochrome p450 3a4 and human cytochrome p450 2c9

Publications (1)

Publication Number Publication Date
ATE434041T1 true ATE434041T1 (de) 2009-07-15

Family

ID=26844805

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00955297T ATE434041T1 (de) 1999-08-05 2000-08-01 Bestimmung humanes cytochrom p450 3a4 (cyp3a4)

Country Status (6)

Country Link
EP (2) EP2000532A1 (de)
JP (1) JP2003506084A (de)
AT (1) ATE434041T1 (de)
CA (1) CA2381455A1 (de)
DE (1) DE60042410D1 (de)
WO (1) WO2001011035A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6623960B1 (en) * 1999-02-12 2003-09-23 The United States Of America As Represented By The Department Of Health And Human Services Agents that bind to and inhibit human cytochrome P450 2C8, 2C9, 2C18 and 2C19
US7148046B2 (en) 2001-04-02 2006-12-12 Astex Therapeutics Limited Crystal structure of cytochrome P450
AU2002257411A1 (en) * 2001-04-30 2002-11-11 Mcgill University Individualization of therapy with antineoplastic agents
EP1438337B1 (de) * 2001-10-25 2006-09-20 Astex Therapeutics Limited Cytochrome p450 2c9 kristalle, strukturen und dessen verwendung
WO2003052425A2 (en) * 2001-12-19 2003-06-26 Xanthus Life Sciences, Inc. Elisa kit for cyp 2c9 metabolic phenotypes
CN105969744A (zh) * 2016-07-26 2016-09-28 王红阳 Cyp3a5蛋白、编码基因、重组载体及其在制备抗肿瘤复发或转移药物中的应用
CN112877296B (zh) * 2021-03-01 2022-10-11 江南大学 一种抗非那西丁单克隆抗体杂交瘤细胞株ad及其制备方法与应用
WO2024223797A1 (en) 2023-04-28 2024-10-31 Institut National de la Santé et de la Recherche Médicale Use of cyp3a4 inhibitors for the treatment of hepatitis d virus (hdv) infections
CN118440208B (zh) * 2024-06-21 2024-09-10 吉林省继明生物科技有限责任公司 一种cyp3a4检测试剂盒以及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298418A (en) * 1991-09-16 1994-03-29 Boyce Thompson Institute For Plant Research, Inc. Cell line isolated from larval midgut tissue of Trichoplusia ni
KR0138005B1 (ko) * 1993-10-21 1998-05-15 김낙두 신규의 화학적 보호제(chemopreventive agent)및 그의 제조방법
US5650295A (en) * 1995-06-02 1997-07-22 Human Genone Sciences, Inc. Macrophage migration inhibitory factor-3
US5939530A (en) * 1995-11-17 1999-08-17 The United States Of America As Represented By The Department Of Health And Human Services Inhibitory and non-inhibitory antigen binding polypeptides against human P450 enzymes
US6300476B1 (en) * 1997-04-10 2001-10-09 Merck & Co., Inc. Anti-peptide antibody against human cytochrome P450 3A4
US6623960B1 (en) * 1999-02-12 2003-09-23 The United States Of America As Represented By The Department Of Health And Human Services Agents that bind to and inhibit human cytochrome P450 2C8, 2C9, 2C18 and 2C19

Also Published As

Publication number Publication date
JP2003506084A (ja) 2003-02-18
WO2001011035A9 (en) 2002-07-11
DE60042410D1 (de) 2009-07-30
EP2000532A1 (de) 2008-12-10
EP1206530B1 (de) 2009-06-17
EP1206530A1 (de) 2002-05-22
WO2001011035A1 (en) 2001-02-15
CA2381455A1 (en) 2001-02-15
EP1206530A4 (de) 2003-05-21

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