ATE428685T1 - AMINO-SUBSTITUTED ETHYLAMINOAGONISTS OF THE BETA2-ADRENERGIC RECEPTOR - Google Patents

AMINO-SUBSTITUTED ETHYLAMINOAGONISTS OF THE BETA2-ADRENERGIC RECEPTOR

Info

Publication number
ATE428685T1
ATE428685T1 AT04784634T AT04784634T ATE428685T1 AT E428685 T1 ATE428685 T1 AT E428685T1 AT 04784634 T AT04784634 T AT 04784634T AT 04784634 T AT04784634 T AT 04784634T AT E428685 T1 ATE428685 T1 AT E428685T1
Authority
AT
Austria
Prior art keywords
ethylaminoagonists
beta2
amino
substituted
adrenergic receptor
Prior art date
Application number
AT04784634T
Other languages
German (de)
Inventor
Martin Linsell
John Jacobsen
Daisuke Saito
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Application granted granted Critical
Publication of ATE428685T1 publication Critical patent/ATE428685T1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • C07D215/26Alcohols; Ethers thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04784634T 2003-09-22 2004-09-21 AMINO-SUBSTITUTED ETHYLAMINOAGONISTS OF THE BETA2-ADRENERGIC RECEPTOR ATE428685T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50568503P 2003-09-22 2003-09-22
PCT/US2004/030833 WO2005030678A2 (en) 2003-09-22 2004-09-21 AMINO-SUBSTITUTED ETHYLAMINO β2 ADRENERGIC RECEPTOR AGONISTS

Publications (1)

Publication Number Publication Date
ATE428685T1 true ATE428685T1 (en) 2009-05-15

Family

ID=34393055

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04784634T ATE428685T1 (en) 2003-09-22 2004-09-21 AMINO-SUBSTITUTED ETHYLAMINOAGONISTS OF THE BETA2-ADRENERGIC RECEPTOR

Country Status (28)

Country Link
US (2) US7399863B2 (en)
EP (1) EP1687257B1 (en)
JP (1) JP2007505931A (en)
KR (1) KR20070015496A (en)
CN (1) CN100465158C (en)
AR (1) AR046085A1 (en)
AT (1) ATE428685T1 (en)
AU (1) AU2004276254A1 (en)
BR (1) BRPI0414634A (en)
CA (1) CA2538037A1 (en)
CO (1) CO5680412A2 (en)
DE (1) DE602004020655D1 (en)
DK (1) DK1687257T3 (en)
ES (1) ES2326172T3 (en)
HK (1) HK1093486A1 (en)
IL (1) IL174026A0 (en)
IS (1) IS8346A (en)
MA (1) MA28089A1 (en)
MX (1) MXPA06003093A (en)
NO (1) NO20061737L (en)
NZ (1) NZ545764A (en)
PL (1) PL1687257T3 (en)
PT (1) PT1687257E (en)
RU (1) RU2385317C2 (en)
SI (1) SI1687257T1 (en)
TW (1) TW200526547A (en)
WO (1) WO2005030678A2 (en)
ZA (1) ZA200602308B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
TW200526547A (en) * 2003-09-22 2005-08-16 Theravance Inc Amino-substituted ethylamino β2 adrenergic receptor agonists
TW200531692A (en) * 2004-01-12 2005-10-01 Theravance Inc Aryl aniline derivatives as β2 adrenergic receptor agonists
BRPI0511695A (en) * 2004-06-03 2008-01-08 Theravance Inc (beta) 2 adrenergic receptor agonists diamine
JP2008507532A (en) * 2004-07-21 2008-03-13 セラヴァンス, インコーポレーテッド Diaryl ether β2 adrenergic receptor agonist
EP1786762A2 (en) * 2004-09-10 2007-05-23 Theravance, Inc. Amidine substituted aryl aniline compounds
JP2008526805A (en) * 2005-01-11 2008-07-24 グラクソ グループ リミテッド Beta-2 adrenergic cinnamate
TWI372749B (en) 2005-03-10 2012-09-21 Theravance Inc Crystalline forms of a biphenyl compound
ES2265276B1 (en) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. DERIVATIVES OF 4- (2-AMINO-1-HYDROXYETHYL) Phenol as agonists of the BETA2 ADRENERGIC RECEIVER.
TW200738658A (en) 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
ES2296516B1 (en) 2006-04-27 2009-04-01 Laboratorios Almirall S.A. DERIVATIVES OF 4- (2-AMINO-1-HYDROXYETHYL) Phenol as agonists of the BETA2 ADRENERGIC RECEIVER.
ES2302447B1 (en) * 2006-10-20 2009-06-12 Laboratorios Almirall S.A. DERIVATIVES OF 4- (2-AMINO-1-HYDROXYETHYL) Phenol as agonists of the BETA2 ADRENERGIC RECEIVER.
TW200833670A (en) 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
JP5608097B2 (en) 2008-01-08 2014-10-15 アレイ バイオファーマ、インコーポレイテッド Pyrrolopyridine as a kinase inhibitor
CA2711741A1 (en) * 2008-01-09 2009-07-16 Array Biopharma Inc. Pyrazolopyridines as kinase inhibitors
EP2096105A1 (en) * 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor
UY31905A (en) 2008-06-18 2010-01-29 Astrazeneca Ab DERIVATIVES OF BENZOXAZINONA, PREPARATION PROCESSES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND APPLICATIONS.
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
CN112645875A (en) * 2020-12-09 2021-04-13 深圳海王医药科技研究院有限公司 Preparation method of procaterol hydrochloride impurity

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US665323A (en) * 1897-12-15 1901-01-01 Merrell Soule Co Method of preparing vegetable-soup powders.
DE1250450B (en) 1962-03-31 1967-09-21 Deutsche Gold- und Silber-Scheideanstalt vormals Roessler, Frankfurt/M Process for the production of amino alcohols and their acid addition salts and quaternary ammonium compounds
AT310146B (en) 1971-04-26 1973-09-25 Boehringer Sohn Ingelheim Process for the production of new N, N'-bis- (β-hydroxyarylethyl) -diaminoalkanes and their acid addition salts
CH545764A (en) 1971-07-27 1974-02-15
BE794414A (en) 1972-01-25 1973-07-23 Sandoz Sa NEW AMINO-ALCOHOLS, THEIR PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT
JPS5913510B2 (en) 1975-12-26 1984-03-30 オオツカセイヤク カブシキガイシヤ Calbostyril Yudou Tainoseizohou
JPS5283619A (en) 1976-01-01 1977-07-12 Yamanouchi Pharmaceut Co Ltd Alpha-substituted aminomethyl benzyl alcohol derivative
JPS609713B2 (en) 1976-10-08 1985-03-12 大塚製薬株式会社 carbostyril derivatives
ZW6584A1 (en) 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
GB8334494D0 (en) 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
GB8507942D0 (en) 1985-03-27 1985-05-01 Beecham Group Plc Compounds
EP0233686A3 (en) 1986-01-11 1989-05-03 Beecham Group Plc Bis phenyl ethanol amines and bis phenyoxypropanolamines having a beta-agonist activity
US5223614A (en) 1987-12-19 1993-06-29 Boehringer Ingelheim Gmbh New quaternary ammonium compounds, their preparation and use
US4894219A (en) 1988-03-29 1990-01-16 University Of Florida Beta-agonist carbostyril derivatives, assay method and pharmacological composition
US5434304A (en) 1990-09-26 1995-07-18 Aktiebolaget Astra Process for preparing formoterol and related compounds
GB9405019D0 (en) 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
US6040344A (en) 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
GB9713819D0 (en) 1997-06-30 1997-09-03 Glaxo Group Ltd Method of reducing the systemic effects of compounds
US6713651B1 (en) 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
US6362371B1 (en) 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
US20020143034A1 (en) 1998-12-30 2002-10-03 Fujisawa Pharmaceutical Co. Ltd. Aminoalcohol derivatives and their use as beta 3 adrenergic agonists
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
US6683115B2 (en) * 1999-06-02 2004-01-27 Theravance, Inc. β2-adrenergic receptor agonists
UA73965C2 (en) * 1999-12-08 2005-10-17 Theravance Inc b2 ADRENERGIC RECEPTOR ANTAGONISTS
OA11558A (en) 1999-12-08 2004-06-03 Advanced Medicine Inc Beta 2-adrenergic receptor agonists.
WO2001083462A1 (en) 2000-04-27 2001-11-08 Boehringer Ingelheim Pharma Kg Novel, slow-acting betamimetics, a method for their production and their use as medicaments
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
DE60120748T2 (en) 2000-11-10 2007-05-16 Eli Lilly And Co., Indianapolis 3-SUBSTITUTED OXINDOLE DERIVATIVES AS BETA-3 AGONISTS
GB0103630D0 (en) 2001-02-14 2001-03-28 Glaxo Group Ltd Chemical compounds
JP2004526720A (en) 2001-03-08 2004-09-02 グラクソ グループ リミテッド β-adrenergic receptor agonist
JP4143413B2 (en) 2001-03-22 2008-09-03 グラクソ グループ リミテッド Formanilide derivatives as β2-adrenergic receptor agonists
PT1425001E (en) 2001-09-14 2009-02-18 Glaxo Group Ltd Phenethanolamine derivatives for treatment of respiratory diseases
WO2003042160A1 (en) 2001-11-13 2003-05-22 Theravance, Inc. Aryl aniline beta-2 adrenergic receptor agonists
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
US20030229058A1 (en) 2001-11-13 2003-12-11 Moran Edmund J. Aryl aniline beta2 adrenergic receptor agonists
GB0204719D0 (en) 2002-02-28 2002-04-17 Glaxo Group Ltd Medicinal compounds
DE60318193T2 (en) 2002-04-25 2008-12-04 Glaxo Group Ltd., Greenford PHENETHANOLAMINDERIVATE
US6747043B2 (en) 2002-05-28 2004-06-08 Theravance, Inc. Alkoxy aryl β2 adrenergic receptor agonists
GB0217225D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicinal compounds
TW200409746A (en) * 2002-07-26 2004-06-16 Theravance Inc Crystalline β2 adrenergic receptor agonist
JP2006528242A (en) 2003-05-08 2006-12-14 セラヴァンス インコーポレーテッド Crystalline form of arylaniline β2 adrenergic receptor agonist
US20040229058A1 (en) * 2003-05-12 2004-11-18 Trouilhet Yves M. Multilayer film
TW200510277A (en) 2003-05-27 2005-03-16 Theravance Inc Crystalline form of β2-adrenergic receptor agonist
TW200526547A (en) * 2003-09-22 2005-08-16 Theravance Inc Amino-substituted ethylamino β2 adrenergic receptor agonists
TW200531692A (en) * 2004-01-12 2005-10-01 Theravance Inc Aryl aniline derivatives as β2 adrenergic receptor agonists
BRPI0511695A (en) * 2004-06-03 2008-01-08 Theravance Inc (beta) 2 adrenergic receptor agonists diamine
JP2008507532A (en) * 2004-07-21 2008-03-13 セラヴァンス, インコーポレーテッド Diaryl ether β2 adrenergic receptor agonist
EP1786762A2 (en) * 2004-09-10 2007-05-23 Theravance, Inc. Amidine substituted aryl aniline compounds

Also Published As

Publication number Publication date
US7964730B2 (en) 2011-06-21
PT1687257E (en) 2009-05-28
WO2005030678A3 (en) 2005-05-26
EP1687257A2 (en) 2006-08-09
AR046085A1 (en) 2005-11-23
AU2004276254A1 (en) 2005-04-07
IL174026A0 (en) 2006-08-01
KR20070015496A (en) 2007-02-05
US20090111850A1 (en) 2009-04-30
CA2538037A1 (en) 2005-04-07
ES2326172T3 (en) 2009-10-02
IS8346A (en) 2006-03-09
HK1093486A1 (en) 2007-03-02
WO2005030678A2 (en) 2005-04-07
RU2006113700A (en) 2006-09-10
MXPA06003093A (en) 2006-06-20
TW200526547A (en) 2005-08-16
MA28089A1 (en) 2006-08-01
ZA200602308B (en) 2007-07-25
CO5680412A2 (en) 2006-09-29
DK1687257T3 (en) 2009-07-20
US20050113411A1 (en) 2005-05-26
JP2007505931A (en) 2007-03-15
DE602004020655D1 (en) 2009-05-28
PL1687257T3 (en) 2009-09-30
CN100465158C (en) 2009-03-04
US7399863B2 (en) 2008-07-15
NZ545764A (en) 2009-12-24
RU2385317C2 (en) 2010-03-27
EP1687257B1 (en) 2009-04-15
SI1687257T1 (en) 2009-10-31
CN1856465A (en) 2006-11-01
BRPI0414634A (en) 2006-11-07
NO20061737L (en) 2006-05-31

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