ATE428413T1 - NEW USE OF PEPTIDE COMPOUNDS FOR THE TREATMENT OF CENTRAL NEUROPATHIC PAIN - Google Patents

NEW USE OF PEPTIDE COMPOUNDS FOR THE TREATMENT OF CENTRAL NEUROPATHIC PAIN

Info

Publication number
ATE428413T1
ATE428413T1 AT04803465T AT04803465T ATE428413T1 AT E428413 T1 ATE428413 T1 AT E428413T1 AT 04803465 T AT04803465 T AT 04803465T AT 04803465 T AT04803465 T AT 04803465T AT E428413 T1 ATE428413 T1 AT E428413T1
Authority
AT
Austria
Prior art keywords
neuropathic pain
treatment
peptide compounds
new use
central neuropathic
Prior art date
Application number
AT04803465T
Other languages
German (de)
Inventor
Thomas Stoehr
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03027742A external-priority patent/EP1537862A1/en
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Application granted granted Critical
Publication of ATE428413T1 publication Critical patent/ATE428413T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

The present invention concerns the use of compounds for treating central neuropathic pain.
AT04803465T 2003-12-02 2004-12-02 NEW USE OF PEPTIDE COMPOUNDS FOR THE TREATMENT OF CENTRAL NEUROPATHIC PAIN ATE428413T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP03027742A EP1537862A1 (en) 2003-12-02 2003-12-02 Novel use of peptide compounds for treating central neuropathic pain
US53089503P 2003-12-22 2003-12-22
EP03029632 2003-12-22
PCT/EP2004/013729 WO2005053667A1 (en) 2003-12-02 2004-12-02 Novel use of peptide compounds for treating central neuropathic pain

Publications (1)

Publication Number Publication Date
ATE428413T1 true ATE428413T1 (en) 2009-05-15

Family

ID=34657533

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04803465T ATE428413T1 (en) 2003-12-02 2004-12-02 NEW USE OF PEPTIDE COMPOUNDS FOR THE TREATMENT OF CENTRAL NEUROPATHIC PAIN

Country Status (17)

Country Link
US (1) US7794987B2 (en)
EP (1) EP1689378B1 (en)
JP (1) JP4664924B2 (en)
KR (1) KR20060111524A (en)
AT (1) ATE428413T1 (en)
AU (1) AU2004294714B2 (en)
BR (1) BRPI0417101A (en)
CA (1) CA2545543A1 (en)
DE (1) DE602004020657D1 (en)
EA (1) EA013590B1 (en)
ES (1) ES2325995T3 (en)
HK (1) HK1095749A1 (en)
IL (1) IL175770A0 (en)
NO (1) NO20063064L (en)
NZ (1) NZ546576A (en)
PL (1) PL1689378T3 (en)
WO (1) WO2005053667A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1243262T3 (en) 2001-03-20 2006-10-02 Sanol Arznei Schwarz Gmbh Hitherto unknown use of a peptide class of compounds to treat non-neuropathic inflammatory pain
ATE228358T1 (en) * 2001-03-21 2002-12-15 Sanol Arznei Schwarz Gmbh NEW USE OF A CLASS OF PEPTIDE COMPOUNDS FOR THE TREATMENT OF ALLODYNIA OR OTHER TYPES OF CHRONIC OR PHANTOMATIC PAIN
JP4664924B2 (en) 2003-12-02 2011-04-06 ウーツェーベー ファルマ ゲーエムベーハー Novel use of peptide compounds for the treatment of central neuropathic pain
EP1579858A1 (en) * 2004-03-26 2005-09-28 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in painful diabetic neuropathy
US20100256179A1 (en) * 2004-03-26 2010-10-07 Ucb Pharma Gmbh Combination therapy for pain in painful diabetic neuropathy
US20070042969A1 (en) * 2004-03-26 2007-02-22 Srz Properties, Inc. Combination therapy for pain in painful diabetic neuropathy
CN1950101B (en) * 2004-04-16 2011-03-30 舒沃茨药物股份公司 Use of peptidic compounds for the prophylaxis and treatment of chronic headache
EP1604655A1 (en) * 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
CA2573125A1 (en) * 2004-08-27 2006-03-02 Schwarz Pharma Ag Novel use of peptide compounds for treating bone cancer pain, chemotherapy-and nucleoside-induced pain
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
US20060252749A1 (en) * 2005-01-28 2006-11-09 Srz Properties, Inc. Lacosamide for add-on therapy of psychosis
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
EP1754476A1 (en) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
US7902401B2 (en) 2006-12-14 2011-03-08 Nps Pharmaceuticals, Inc. Fluorinated compounds
ATE530175T1 (en) * 2006-06-08 2011-11-15 Ucb Pharma Gmbh THERAPEUTIC COMBINATION FOR PAINFUL MEDICAL CONDITIONS
EP1873527A1 (en) * 2006-06-30 2008-01-02 Schwarz Pharma Ag Method for identifying CRMP modulators
AR061476A1 (en) 2006-06-15 2008-08-27 Sanol Arznei Schwarz Gmbh PHARMACEUTICAL COMPOSITION WITH SYNERGIC ANTI-CONVULSIVE EFFECT
CN101466390B (en) 2006-06-15 2014-03-12 优时比制药有限公司 Pharmaceutical composition with synergistic anticonvulsant effect
WO2008070994A1 (en) 2006-12-14 2008-06-19 Nps Pharmaceuticals, Inc. Use of d-serine derivatives for the treatment of anxiety disorders
EP2214657A1 (en) * 2007-10-23 2010-08-11 UCB Pharma GmbH Compounds for treating demyelination conditions
WO2009121483A1 (en) * 2008-04-02 2009-10-08 Sanofi-Aventis Highly bridged peptides from actinomadura namibiensis
EP2468261A1 (en) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulation of lacosamide
WO2012072256A2 (en) 2010-12-02 2012-06-07 Ucb Pharma Gmbh Once daily formulation of lacosamide
KR20210115502A (en) 2020-03-13 2021-09-27 (주)포에버엔케이 Methods and Transdermal Injectable Composition for Pain Relief Containing Functional Peptide
KR20230042193A (en) 2021-09-19 2023-03-28 (주)포에버엔케이 Methods and Transdermal Injectable Composition for Pain Relief Containing Functional Peptide

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US5654301A (en) * 1985-02-15 1997-08-05 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
EP0529680B1 (en) 1987-08-01 1998-05-13 Takeda Chemical Industries, Ltd. Intermediates, their production and their use for preparing alpha-unsaturated amines
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
YU47834B (en) 1989-08-10 1996-01-09 Schering Agrochemical Limited THE AZOLE PESTICIDE
TW217417B (en) 1991-12-04 1993-12-11 Manyu Seiyaku Kk
US5585358A (en) * 1993-07-06 1996-12-17 Yissum Research Development Corporation Of The Hebrew University Of Jerusalem Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents
GB9504854D0 (en) * 1994-03-31 1995-04-26 Zeneca Ltd Nitrogen derivatives
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5849737A (en) * 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
JP4313435B2 (en) * 1995-07-24 2009-08-12 トラスティーズ オブ ボストン ユニバーシティー Inhibition of NMDA receptor activity by pregnenolone sulfate derivatives
US6114390A (en) * 1995-11-30 2000-09-05 Karl Thomae Gmbh Amino acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
DE19544687A1 (en) 1995-11-30 1997-06-05 Thomae Gmbh Dr K Amino acid derivatives, medicaments containing these compounds and processes for their preparation
US6037324A (en) * 1996-01-04 2000-03-14 Leukosite, Inc. Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor
GB9601724D0 (en) * 1996-01-29 1996-03-27 Merck Sharp & Dohme Therapeutic agents
US5773475A (en) * 1997-03-17 1998-06-30 Research Corporation Technologies, Inc. Anticonvulsant enantiomeric amino acid derivatives
US6277825B1 (en) * 1996-07-22 2001-08-21 University Of Utah Research Foundation Use of conantokins for treating pain
DK0934061T6 (en) * 1996-07-24 2015-01-26 Warner Lambert Co Isobutylgaba and its derivatives for the treatment of pain
US6589994B1 (en) 1996-08-30 2003-07-08 Nps Pharmaceuticals, Inc. Treating a variety of pathological conditions, including spasticity and convulsions, by effecting a modulation of CNS activity with isovaleramide, isovaleric acid, or a related compound
US6048899A (en) * 1997-03-17 2000-04-11 Research Corporation Tech., Inc. Anticonvulsant enantiomeric amino acid derivatives
EP0997147B1 (en) 1997-07-08 2006-03-15 Ono Pharmaceutical Co., Ltd. Amino acid derivatives
WO1999003460A1 (en) * 1997-07-15 1999-01-28 Research Corporation Technologies, Inc. Amino acid derivatives useful to treat stroke
US6737408B1 (en) * 1997-08-07 2004-05-18 University Of Cincinnati Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm
WO1999007413A1 (en) 1997-08-11 1999-02-18 Algos Pharmaceutical Corporation Substance p inhibitors in combination with nmda-blockers for treating pain
US6492553B1 (en) * 1998-01-29 2002-12-10 Aventis Pharamaceuticals Inc. Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds
US6673832B1 (en) 1998-05-04 2004-01-06 Gudarz Davar Methods for identifying compounds for treating pain
GB9816228D0 (en) 1998-07-24 1998-09-23 Pfizer Ltd Isoquinolines
DE69908626T2 (en) * 1998-10-09 2004-05-13 Novartis Ag ORAL COMBINATION OF LUFENURON AND NITENPYRAM AGAINST FLAE
EP1121111B1 (en) 1998-10-15 2010-02-10 Imperial Innovations Limited Compounds for the treatment of weight loss
HUP0201402A3 (en) 1999-09-03 2003-12-29 Actelion Pharmaceuticals Ltd Bis-sulfonamides, process for their preparation and pharmaceutical compositions containing them
SE0001373D0 (en) 2000-04-13 2000-04-13 Karolinska Innovations Ab NPY Y1 receptor agonists and antagonists
CA2348847A1 (en) 2000-05-31 2001-11-30 Pfizer Inc. New isoxazole-sulfonamide endothelin antagonists
ES2245377T3 (en) * 2000-08-17 2006-01-01 Teva Pharmaceutical Industries Ltd. USE OF DERIVATIVES OF AMIDAS OF VALPROIC ACID AND AMIDAS OF 2-VALPROENIC ACID FOR THE TREATMENT OR PREVENTION OF PAIN AND / OR HEADACHE DISORDERS.
DE10041478A1 (en) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh New pharmaceutical composition
EP1695703B1 (en) * 2000-08-25 2010-08-11 Research Corporation Technologies, Inc. Anticonvulsant amino acids for the treatment of obsessive-compulsive neurosis
US6821978B2 (en) * 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
ATE397584T1 (en) 2000-11-21 2008-06-15 Ucb Pharma Sa N-ALKYLATED GABA COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
CA2434495A1 (en) 2001-01-30 2002-08-08 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
DK1243262T3 (en) * 2001-03-20 2006-10-02 Sanol Arznei Schwarz Gmbh Hitherto unknown use of a peptide class of compounds to treat non-neuropathic inflammatory pain
ATE228358T1 (en) * 2001-03-21 2002-12-15 Sanol Arznei Schwarz Gmbh NEW USE OF A CLASS OF PEPTIDE COMPOUNDS FOR THE TREATMENT OF ALLODYNIA OR OTHER TYPES OF CHRONIC OR PHANTOMATIC PAIN
KR20040016844A (en) 2001-03-27 2004-02-25 액테리온 파마슈티칼 리미티드 1,2,3,4-tetrahydroisoquinolines derivatives as urotensin ⅱ receptors antagonists
ITMI20011308A1 (en) 2001-06-21 2002-12-21 Nicox Sa DRUGS FOR CHRONIC PAIN
FR2831820B1 (en) 2001-11-05 2004-08-20 Ethypharm Sa ORODISPERSIBLE TABLET HAVING HIGH HOMOGENEITY AND PREPARATION METHOD THEREOF
WO2003099338A2 (en) * 2002-05-17 2003-12-04 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
GB0213669D0 (en) 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
JP2006514110A (en) 2002-11-11 2006-04-27 バイエル・ヘルスケア・アクチェンゲゼルシャフト Phenyl or heteroarylaminoalkane derivatives as IP receptor antagonists
US7687080B2 (en) * 2002-11-25 2010-03-30 Taraxos Inc. Treatment of neuropathy
US20040209960A1 (en) 2003-01-30 2004-10-21 Dynogen Pharmaceuticals, Inc. Methods of treating lower urinary tract disorders using sodium channell modulators
AU2004207009A1 (en) 2003-01-30 2004-08-12 Dynogen Pharmaceuticals, Inc. Use of sodium channel modulators for treating gastrointestinal tract disorders
US20040266743A1 (en) 2003-05-09 2004-12-30 Pharmacia Corporation Combination of an aldosterone receptor antagonist and a renin inhibitor
JP2007527412A (en) 2003-10-24 2007-09-27 エグゼリクシス， インコーポレイテッド TAO kinase modulator and methods of use
EP1537862A1 (en) 2003-12-02 2005-06-08 Schwarz Pharma Ag Novel use of peptide compounds for treating central neuropathic pain
JP4664924B2 (en) 2003-12-02 2011-04-06 ウーツェーベー ファルマ ゲーエムベーハー Novel use of peptide compounds for the treatment of central neuropathic pain
US20060009384A1 (en) * 2003-12-05 2006-01-12 David Rudd Novel use of peptide compounds for treating status epilepticus or related conditions
EP1541138A1 (en) 2003-12-05 2005-06-15 Schwarz Pharma Ag Novel use of peptide compounds for treating status epilepticus or related conditions
US20070042969A1 (en) * 2004-03-26 2007-02-22 Srz Properties, Inc. Combination therapy for pain in painful diabetic neuropathy
EP1579858A1 (en) 2004-03-26 2005-09-28 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in painful diabetic neuropathy
US20050227961A1 (en) * 2004-04-08 2005-10-13 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of neuropathic pain, fibromyalgia and chronic fatigue syndrome
CN1950101B (en) * 2004-04-16 2011-03-30 舒沃茨药物股份公司 Use of peptidic compounds for the prophylaxis and treatment of chronic headache
EP1604654A1 (en) * 2004-05-18 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating dyskinesia
EP1604655A1 (en) * 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
EP1604656A1 (en) * 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
US7427601B2 (en) * 2004-06-24 2008-09-23 Schwarz Pharma Ag Method for treating tremor
CA2573125A1 (en) * 2004-08-27 2006-03-02 Schwarz Pharma Ag Novel use of peptide compounds for treating bone cancer pain, chemotherapy-and nucleoside-induced pain
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
US20060252749A1 (en) * 2005-01-28 2006-11-09 Srz Properties, Inc. Lacosamide for add-on therapy of psychosis
EP1688137A1 (en) 2005-01-28 2006-08-09 Schwarz Pharma Ag SPM 927 for add-on therapy of schizophrenia
EP1754476A1 (en) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
US20070048372A1 (en) * 2005-08-18 2007-03-01 Srz Properties, Inc. Method for treating non-inflammatory osteoarthritic pain

Also Published As

Publication number Publication date
EP1689378A1 (en) 2006-08-16
CA2545543A1 (en) 2005-06-16
PL1689378T3 (en) 2009-09-30
HK1095749A1 (en) 2007-05-18
US20050209163A1 (en) 2005-09-22
KR20060111524A (en) 2006-10-27
WO2005053667A1 (en) 2005-06-16
JP4664924B2 (en) 2011-04-06
EA013590B1 (en) 2010-06-30
AU2004294714B2 (en) 2009-12-10
DE602004020657D1 (en) 2009-05-28
BRPI0417101A (en) 2007-02-06
US7794987B2 (en) 2010-09-14
IL175770A0 (en) 2006-09-05
JP2007513119A (en) 2007-05-24
NZ546576A (en) 2009-05-31
EA200601074A1 (en) 2006-10-27
NO20063064L (en) 2006-09-01
ES2325995T3 (en) 2009-09-28
EP1689378B1 (en) 2009-04-15
AU2004294714A1 (en) 2005-06-16

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