ATE425459T1 - Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten - Google Patents

Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten

Info

Publication number
ATE425459T1
ATE425459T1 AT00959706T AT00959706T ATE425459T1 AT E425459 T1 ATE425459 T1 AT E425459T1 AT 00959706 T AT00959706 T AT 00959706T AT 00959706 T AT00959706 T AT 00959706T AT E425459 T1 ATE425459 T1 AT E425459T1
Authority
AT
Austria
Prior art keywords
subunit
receptors
nmda
modulator
subunits
Prior art date
Application number
AT00959706T
Other languages
English (en)
Inventor
David H Farb
Shelley Russek
Ming-Kuei Jang
Terrell Gibbs
Nader Yaghoubi
Original Assignee
Univ Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22540293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE425459(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Boston filed Critical Univ Boston
Application granted granted Critical
Publication of ATE425459T1 publication Critical patent/ATE425459T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
AT00959706T 1999-08-31 2000-08-31 Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten ATE425459T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15180299P 1999-08-31 1999-08-31

Publications (1)

Publication Number Publication Date
ATE425459T1 true ATE425459T1 (de) 2009-03-15

Family

ID=22540293

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00959706T ATE425459T1 (de) 1999-08-31 2000-08-31 Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten

Country Status (7)

Country Link
US (1) US6623933B1 (de)
EP (1) EP1212618B1 (de)
AT (1) ATE425459T1 (de)
AU (1) AU782250B2 (de)
CA (1) CA2383047A1 (de)
DE (1) DE60041773D1 (de)
WO (1) WO2001016601A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036128A1 (en) * 2000-11-06 2002-05-10 Trustees Of Boston University Neuroactive steroid derivatives and methods of use
AUPR731901A0 (en) * 2001-08-28 2001-09-20 Goodchild, Colin Stanley Method of treatment
US20120322781A1 (en) 2010-01-14 2012-12-20 Umecrine Mood Ab Pharmaceutical composition comprising 3-beta-hydroxy-5-alpha-pregnan-20-one with improved storage and solubility properties
CZ305733B6 (cs) * 2014-08-26 2016-02-24 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Amfifilní sloučeniny s neuroprotektivními účinky
CN108148106A (zh) * 2016-12-05 2018-06-12 江苏恩华络康药物研发有限公司 一类水溶性别孕烯醇酮衍生物及其用途
CN114957445B (zh) * 2022-05-31 2023-09-19 陕西脉元生物科技有限公司 一种nmdar nr1亚基、nmdar的突变体及其构建方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2110934A1 (en) 1992-12-11 1994-06-12 Robert L. Foldes Human cns receptors of the nmda-r1 family
GB2286188B (en) * 1993-04-20 1997-11-12 Salk Inst Biotech Ind Human N-methyl-D-aspartate receptor subunits,nucleic acids encoding same and uses therefor
US5888996A (en) 1995-07-26 1999-03-30 Trustees Of Boston University Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
WO1997003677A1 (en) 1995-07-24 1997-02-06 Trustees Of Boston University Inhibition of nmda receptor activity by pregnenolone sulfate derivatives
US6521414B2 (en) * 2000-02-01 2003-02-18 Agy Therapeutics, Inc. Methods for identifying a modulator of the interaction of NMDA receptor with protein tyrosine phosphatase L1

Also Published As

Publication number Publication date
AU782250B2 (en) 2005-07-14
EP1212618A4 (de) 2005-04-06
US6623933B1 (en) 2003-09-23
EP1212618A1 (de) 2002-06-12
CA2383047A1 (en) 2001-03-08
AU7098100A (en) 2001-03-26
WO2001016601A1 (en) 2001-03-08
DE60041773D1 (de) 2009-04-23
EP1212618B1 (de) 2009-03-11

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