ATE421878T1 - Verfahren zur unterdrückung oder umkehrung der tau-filament-bildungspolymerisation - Google Patents

Verfahren zur unterdrückung oder umkehrung der tau-filament-bildungspolymerisation

Info

Publication number
ATE421878T1
ATE421878T1 AT02759223T AT02759223T ATE421878T1 AT E421878 T1 ATE421878 T1 AT E421878T1 AT 02759223 T AT02759223 T AT 02759223T AT 02759223 T AT02759223 T AT 02759223T AT E421878 T1 ATE421878 T1 AT E421878T1
Authority
AT
Austria
Prior art keywords
filament formation
polymerization
carbon atoms
tau filament
suppressing
Prior art date
Application number
AT02759223T
Other languages
English (en)
Inventor
Jeff Kuret
Sam Khatami
Original Assignee
Neuronautics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuronautics Inc filed Critical Neuronautics Inc
Application granted granted Critical
Publication of ATE421878T1 publication Critical patent/ATE421878T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Artificial Filaments (AREA)
AT02759223T 2001-07-31 2002-07-31 Verfahren zur unterdrückung oder umkehrung der tau-filament-bildungspolymerisation ATE421878T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/919,508 US6479528B1 (en) 2001-07-31 2001-07-31 Methods for inhibiting or reversing tau filament formation polymerization

Publications (1)

Publication Number Publication Date
ATE421878T1 true ATE421878T1 (de) 2009-02-15

Family

ID=25442207

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02759223T ATE421878T1 (de) 2001-07-31 2002-07-31 Verfahren zur unterdrückung oder umkehrung der tau-filament-bildungspolymerisation

Country Status (7)

Country Link
US (1) US6479528B1 (de)
EP (2) EP1418910B1 (de)
JP (1) JP2005500346A (de)
AT (1) ATE421878T1 (de)
CA (1) CA2455969A1 (de)
DE (1) DE60231047D1 (de)
WO (1) WO2003011290A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001285311B2 (en) 2000-08-29 2005-09-15 Biocon, Ltd Immunoregulatory compounds, derivatives thereof and their use
US8048924B2 (en) 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
WO2004073651A2 (en) * 2003-02-18 2004-09-02 The Ohio State University Research Foundation Identifying inhibitors of intracellular protein fibrillization
US20050032857A1 (en) * 2003-06-19 2005-02-10 Jeff Kuret Methods for inhibiting or reversing tau filament fibrillization
ES2565848T3 (es) 2004-07-07 2016-04-07 Biocon Limited Síntesis de compuestos inmunorreguladores unidos por grupos azoicos
WO2006007864A1 (en) * 2004-07-17 2006-01-26 Max Planck Geselllschaft Zur Förderung Der Wissenschaft Treating neurodegenerative conditions
US20060038780A1 (en) * 2004-08-20 2006-02-23 Mese John C System and method for automatically establishing handedness settings of mouse-like input device
US7666886B2 (en) * 2005-07-15 2010-02-23 The Regents Of The University Of California Compounds and methods for the diagnosis and treatment of amyloid associated diseases
WO2007076875A2 (en) * 2006-01-06 2007-07-12 Aarhus Universitet Compounds acting on the serotonin transporter
US20110144029A1 (en) * 2009-09-30 2011-06-16 Board Of Regents, The University Of Texas System Model Systems and Materials for the Study and Treatment of Neurodegenerative Diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2219880A1 (en) * 1995-05-01 1996-11-07 University Of Pittsburgh Azocompounds for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition
AU1529297A (en) * 1996-01-24 1997-08-20 Warner-Lambert Company Method of imaging amyloid deposits
JP2000281591A (ja) * 1999-03-26 2000-10-10 Bf Kenkyusho:Kk ベーシックブルー４１およびパラチン・ファスト・ブラックｗａｎによるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物

Also Published As

Publication number Publication date
US6479528B1 (en) 2002-11-12
EP1418910B1 (de) 2009-01-28
CA2455969A1 (en) 2003-02-13
JP2005500346A (ja) 2005-01-06
EP1418910A1 (de) 2004-05-19
DE60231047D1 (de) 2009-03-19
EP1418910A4 (de) 2005-01-05
EP2090309A1 (de) 2009-08-19
WO2003011290A1 (en) 2003-02-13

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Legal Events

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