ATE413398T1 - THIOAMIDE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS - Google Patents
THIOAMIDE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORSInfo
- Publication number
- ATE413398T1 ATE413398T1 AT05735464T AT05735464T ATE413398T1 AT E413398 T1 ATE413398 T1 AT E413398T1 AT 05735464 T AT05735464 T AT 05735464T AT 05735464 T AT05735464 T AT 05735464T AT E413398 T1 ATE413398 T1 AT E413398T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor modulators
- progesterone receptor
- thioamide
- thioamide derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Ink Jet (AREA)
Abstract
Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56056904P | 2004-04-08 | 2004-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE413398T1 true ATE413398T1 (en) | 2008-11-15 |
Family
ID=34965700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05735464T ATE413398T1 (en) | 2004-04-08 | 2005-04-07 | THIOAMIDE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS |
Country Status (14)
Country | Link |
---|---|
US (4) | US7358246B2 (en) |
EP (1) | EP1732921B1 (en) |
JP (1) | JP4869221B2 (en) |
CN (1) | CN100522960C (en) |
AT (1) | ATE413398T1 (en) |
AU (1) | AU2005233591B2 (en) |
BR (1) | BRPI0509209A (en) |
CA (1) | CA2561014C (en) |
DE (1) | DE602005010840D1 (en) |
DK (1) | DK1732921T3 (en) |
ES (1) | ES2317223T3 (en) |
MX (1) | MXPA06011696A (en) |
PL (1) | PL1732921T3 (en) |
WO (1) | WO2005100346A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE409699T1 (en) * | 2004-04-08 | 2008-10-15 | Wyeth Corp | METHOD FOR MINIMIZING THIOAMIDE POLLUTION |
EP1732921B1 (en) * | 2004-04-08 | 2008-11-05 | Wyeth | Thioamide derivatives as progesterone receptor modulators |
GT200500185A (en) * | 2004-08-09 | 2006-04-10 | PROGESTERONE RECEIVER MODULATORS UNDERSTANDING PIRROL-OXINDOL DERIVATIVES AND THEIR USES | |
US20070093548A1 (en) * | 2005-10-25 | 2007-04-26 | Wyeth | Use of progesterone receptor modulators |
US7618989B2 (en) * | 2006-08-15 | 2009-11-17 | Wyeth | Tricyclic oxazolidone derivatives useful as PR modulators |
JP2011507853A (en) * | 2007-12-20 | 2011-03-10 | テバ ウィメンズ ヘルス インコーポレイテッド | Dosage regimens and pharmaceutical compositions and packages for emergency contraception |
CN107281215A (en) * | 2016-04-01 | 2017-10-24 | 复旦大学附属妇产科医院 | Purposes of the hydrogen sulfide donor sodium hydrosulfide in pharmacy |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
US4295987A (en) | 1979-12-26 | 1981-10-20 | The Procter & Gamble Company | Cross-linked sodium polyacrylate absorbent |
US4959217A (en) | 1986-05-22 | 1990-09-25 | Syntex (U.S.A.) Inc. | Delayed/sustained release of macromolecules |
AU608891B2 (en) | 1987-09-24 | 1991-04-18 | Merck & Co., Inc. | Solubility modulated drug delivery device |
US5273752A (en) | 1989-07-18 | 1993-12-28 | Alza Corporation | Controlled release dispenser comprising beneficial agent |
US5124455A (en) | 1990-08-08 | 1992-06-23 | American Home Products Corporation | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents |
US5459151A (en) | 1993-04-30 | 1995-10-17 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents |
US5854388A (en) | 1993-06-24 | 1998-12-29 | Washington State University Research Foundation | Angiotensin IV peptides and receptor |
US5817343A (en) | 1996-05-14 | 1998-10-06 | Alkermes, Inc. | Method for fabricating polymer-based controlled-release devices |
US5756127A (en) | 1996-10-29 | 1998-05-26 | Wright Medical Technology, Inc. | Implantable bioresorbable string of calcium sulfate beads |
FI971385A0 (en) | 1997-04-04 | 1997-04-04 | Bioxid Oy | Biocompatible composition, methodological method |
US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
NZ515353A (en) * | 1999-05-04 | 2004-03-26 | Ligand Pharm Inc | Cyclothiocarbamate derivatives as progesterone receptor modulators |
US6355648B1 (en) | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
US6417214B1 (en) | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
TR200103288T2 (en) * | 1999-05-04 | 2002-04-22 | American Home Products Corporation | Thio-oxindole derivatives |
US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
MXPA02001471A (en) | 1999-08-10 | 2002-07-02 | Smithkline Beecham Corp | 1,4-substituted 4,4-diaryl cyclohexanes. |
US6258833B1 (en) | 1999-12-23 | 2001-07-10 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
JP4716547B2 (en) * | 2000-08-10 | 2011-07-06 | 住友精化株式会社 | Method for producing 2-phenylthiazoles |
US20030225273A1 (en) * | 2002-03-21 | 2003-12-04 | Michaelides Michael R. | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors |
TWI273104B (en) | 2002-06-06 | 2007-02-11 | Eisai Co Ltd | Novel fused imidazole derivative |
AR040644A1 (en) | 2002-06-25 | 2005-04-13 | Wyeth Corp | A BENZOXAZINE-2-TIONA PROGESTERONE RECEIVER MODULATORS, A PHARMACEUTICAL COMPOSITION, USE OF THE COMPOUND TO PREPARE A DEDICATION TO TREAT A NEOPLASIC-HORMONE-DEPENDENT DISEASE AND THE USE OF A BENZOXIONINE-2-BENZOYNAMINE-2-ILYNAMINE-2-TIONAZYNAMINE-2-TIONA-BENZOYNAMINE-2-TIONAIN OR BENZOXAZINA-2-ILIDEN |
JP2005535624A (en) * | 2002-06-25 | 2005-11-24 | ワイス | Use of cyclothiocarbamate derivatives in the treatment of hormone-related symptoms |
JP2005535625A (en) | 2002-06-25 | 2005-11-24 | ワイス | Use of thiooxindole derivatives in the treatment of skin disorders |
IL165395A0 (en) | 2002-06-25 | 2006-01-15 | Wyeth Corp | Use of thio-oxubdile derivatives in treatment of hormone-related conditions |
CA2561047C (en) | 2004-04-08 | 2013-07-16 | Wyeth | Method for preparing 3-cyclopentyloxy-4-methoxybenzaldehyde |
ATE409699T1 (en) | 2004-04-08 | 2008-10-15 | Wyeth Corp | METHOD FOR MINIMIZING THIOAMIDE POLLUTION |
EP1732921B1 (en) | 2004-04-08 | 2008-11-05 | Wyeth | Thioamide derivatives as progesterone receptor modulators |
AU2005237520B2 (en) | 2004-04-27 | 2012-01-19 | Wyeth | Purification of progesterone receptor modulators |
-
2005
- 2005-04-07 EP EP05735464A patent/EP1732921B1/en not_active Not-in-force
- 2005-04-07 AU AU2005233591A patent/AU2005233591B2/en not_active Ceased
- 2005-04-07 BR BRPI0509209-4A patent/BRPI0509209A/en not_active IP Right Cessation
- 2005-04-07 DE DE602005010840T patent/DE602005010840D1/en active Active
- 2005-04-07 MX MXPA06011696A patent/MXPA06011696A/en active IP Right Grant
- 2005-04-07 CN CNB2005800108301A patent/CN100522960C/en not_active Expired - Fee Related
- 2005-04-07 US US11/100,860 patent/US7358246B2/en not_active Expired - Fee Related
- 2005-04-07 JP JP2007507494A patent/JP4869221B2/en not_active Expired - Fee Related
- 2005-04-07 CA CA2561014A patent/CA2561014C/en not_active Expired - Fee Related
- 2005-04-07 WO PCT/US2005/011757 patent/WO2005100346A1/en active Application Filing
- 2005-04-07 PL PL05735464T patent/PL1732921T3/en unknown
- 2005-04-07 DK DK05735464T patent/DK1732921T3/en active
- 2005-04-07 AT AT05735464T patent/ATE413398T1/en not_active IP Right Cessation
- 2005-04-07 ES ES05735464T patent/ES2317223T3/en active Active
-
2008
- 2008-03-07 US US12/044,287 patent/US7511071B2/en not_active Expired - Fee Related
-
2009
- 2009-02-12 US US12/369,789 patent/US7659265B2/en not_active Expired - Fee Related
-
2010
- 2010-02-02 US US12/698,472 patent/US8168672B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2005233591A1 (en) | 2005-10-27 |
CA2561014C (en) | 2013-09-10 |
US20050227971A1 (en) | 2005-10-13 |
WO2005100346A1 (en) | 2005-10-27 |
ES2317223T3 (en) | 2009-04-16 |
US7358246B2 (en) | 2008-04-15 |
US7511071B2 (en) | 2009-03-31 |
EP1732921A1 (en) | 2006-12-20 |
DE602005010840D1 (en) | 2008-12-18 |
MXPA06011696A (en) | 2006-12-14 |
US7659265B2 (en) | 2010-02-09 |
EP1732921B1 (en) | 2008-11-05 |
CN1938299A (en) | 2007-03-28 |
CA2561014A1 (en) | 2005-10-27 |
DK1732921T3 (en) | 2009-02-23 |
JP2007532564A (en) | 2007-11-15 |
US20080167299A1 (en) | 2008-07-10 |
US20090143345A1 (en) | 2009-06-04 |
JP4869221B2 (en) | 2012-02-08 |
US8168672B2 (en) | 2012-05-01 |
BRPI0509209A (en) | 2007-08-28 |
CN100522960C (en) | 2009-08-05 |
AU2005233591B2 (en) | 2011-10-27 |
US20100197645A1 (en) | 2010-08-05 |
PL1732921T3 (en) | 2009-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |