ATE413172T1 - Peptidomimetische hemmer von hiv-protease - Google Patents
Peptidomimetische hemmer von hiv-proteaseInfo
- Publication number
- ATE413172T1 ATE413172T1 AT05754104T AT05754104T ATE413172T1 AT E413172 T1 ATE413172 T1 AT E413172T1 AT 05754104 T AT05754104 T AT 05754104T AT 05754104 T AT05754104 T AT 05754104T AT E413172 T1 ATE413172 T1 AT E413172T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- hiv
- protease
- peptidomimmetic
- hiv protease
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 108091005804 Peptidases Proteins 0.000 title abstract 3
- 239000004365 Protease Substances 0.000 title abstract 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 3
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 108010010369 HIV Protease Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- WEQJQNWXCSUVMA-RYUDHWBXSA-N Phe-Pro Chemical compound C([C@H]([NH3+])C(=O)N1[C@@H](CCC1)C([O-])=O)C1=CC=CC=C1 WEQJQNWXCSUVMA-RYUDHWBXSA-N 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229940121357 antivirals Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000816 peptidomimetic Substances 0.000 abstract 1
- 230000002064 post-exposure prophylaxis Effects 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000151A ITPD20040151A1 (it) | 2004-06-15 | 2004-06-15 | Inibitori peptidomimetici di proteasi retrovirali e loro uso come antivirali |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE413172T1 true ATE413172T1 (de) | 2008-11-15 |
Family
ID=34979350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05754104T ATE413172T1 (de) | 2004-06-15 | 2005-06-15 | Peptidomimetische hemmer von hiv-protease |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7691818B2 (de) |
| EP (1) | EP1768665B1 (de) |
| AT (1) | ATE413172T1 (de) |
| CA (1) | CA2569729C (de) |
| DE (1) | DE602005010869D1 (de) |
| IT (1) | ITPD20040151A1 (de) |
| WO (1) | WO2005123067A1 (de) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6900238B1 (en) * | 1995-12-07 | 2005-05-31 | The Scripps Research Institute | HIV protease inhibitors |
| CA2467798A1 (en) * | 2001-11-19 | 2003-05-30 | Pharmacia & Upjohn Company | Amine 1,2- and 1,3-diol compounds and their use for treatment of alzheimer's disease |
-
2004
- 2004-06-15 IT IT000151A patent/ITPD20040151A1/it unknown
-
2005
- 2005-06-15 US US11/629,720 patent/US7691818B2/en not_active Expired - Fee Related
- 2005-06-15 WO PCT/EP2005/052770 patent/WO2005123067A1/en not_active Ceased
- 2005-06-15 DE DE602005010869T patent/DE602005010869D1/de not_active Expired - Lifetime
- 2005-06-15 CA CA2569729A patent/CA2569729C/en not_active Expired - Fee Related
- 2005-06-15 EP EP05754104A patent/EP1768665B1/de not_active Expired - Lifetime
- 2005-06-15 AT AT05754104T patent/ATE413172T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005010869D1 (de) | 2008-12-18 |
| EP1768665B1 (de) | 2008-11-05 |
| US20070207968A1 (en) | 2007-09-06 |
| US7691818B2 (en) | 2010-04-06 |
| EP1768665A1 (de) | 2007-04-04 |
| WO2005123067A1 (en) | 2005-12-29 |
| CA2569729A1 (en) | 2005-12-29 |
| CA2569729C (en) | 2013-08-20 |
| ITPD20040151A1 (it) | 2004-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AP1717A (en) | Sulfonamide inhibitors of aspartyl protease. | |
| IS7556A (is) | Uppsöfnun í frumu á phosphomate hliðstæðum a HIV próteasa hindrandi efnasamböndum | |
| EA199700330A1 (ru) | Сульфонамидные ингибиторы аспартил-протеазы, содержащие окисленный гетероцикл | |
| CY1112632T1 (el) | Αναστολεις ασπαρτυλ πρωτεασης | |
| MX9603909A (es) | Derivados de sulfonamida como inhibidores de proteasa aspartilo. | |
| ES2240446T3 (es) | Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c. | |
| ATE311391T1 (de) | Aspartyl-protease-inhibitoren | |
| DK0815124T3 (da) | Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser | |
| EA200702242A1 (ru) | Использование сульфонамидного соединения для улучшения фармакокинетики лекарственного средства | |
| DE60306934D1 (de) | Verwendung von Nitrilenverbindungen als Arztneimittel | |
| ATE292109T1 (de) | Substituierte benzamide als inhibitoren von rhinovirus 3c protease | |
| EA200500533A1 (ru) | Пептидные производные - ингибиторы слияния при вич-инфекции | |
| ATE413172T1 (de) | Peptidomimetische hemmer von hiv-protease | |
| WO2007002172A3 (en) | Hiv-1 protease inhibitors | |
| EP1546415A4 (de) | Anti-tsg101-antikörper und ihre verwendungen bei der behandlung von virusinfektionen | |
| NO20024522D0 (no) | Sammensetninger med anti-hiv-aktivitet | |
| MY135869A (en) | Inhibitors of aspartyl protease | |
| MX9708057A (es) | Sulfonamidas que contienen thf inhibidoras de la aspartilproteasa. | |
| PY0000026A (es) | Sulfonamidas inhibidoras de la aspartil-proteasa |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |