ATE40893T1 - PROCESS FOR THE PRODUCTION OF (8S)-8FLUOROERYTHROMYCINS. - Google Patents

PROCESS FOR THE PRODUCTION OF (8S)-8FLUOROERYTHROMYCINS.

Info

Publication number
ATE40893T1
ATE40893T1 AT84201002T AT84201002T ATE40893T1 AT E40893 T1 ATE40893 T1 AT E40893T1 AT 84201002 T AT84201002 T AT 84201002T AT 84201002 T AT84201002 T AT 84201002T AT E40893 T1 ATE40893 T1 AT E40893T1
Authority
AT
Austria
Prior art keywords
production
fluoroerythromycins
anhydroerythromycins
hemiketal
synthesis
Prior art date
Application number
AT84201002T
Other languages
German (de)
Inventor
Luciano Toscano
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Application granted granted Critical
Publication of ATE40893T1 publication Critical patent/ATE40893T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

For the synthesis of (8S)-8-fluoroerythromycins the corresponding 8,9-anhydroerythromycins 6,9-hemiketal are directly fluorinated with perchloryl fluoride.
AT84201002T 1983-07-18 1984-07-10 PROCESS FOR THE PRODUCTION OF (8S)-8FLUOROERYTHROMYCINS. ATE40893T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22104/83A IT1163796B (en) 1983-07-18 1983-07-18 PROCEDURE FOR THE PREPARATION OF (8S) -8-FLUOROERITROMICINA
EP84201002A EP0135207B1 (en) 1983-07-18 1984-07-10 A process for the preparation of (8s)-8-fluoroerythromycins

Publications (1)

Publication Number Publication Date
ATE40893T1 true ATE40893T1 (en) 1989-03-15

Family

ID=11191551

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84201002T ATE40893T1 (en) 1983-07-18 1984-07-10 PROCESS FOR THE PRODUCTION OF (8S)-8FLUOROERYTHROMYCINS.

Country Status (10)

Country Link
US (1) US4673736A (en)
EP (1) EP0135207B1 (en)
JP (1) JPS6038394A (en)
KR (1) KR910008110B1 (en)
AT (1) ATE40893T1 (en)
CA (1) CA1223253A (en)
DE (1) DE3476804D1 (en)
FI (1) FI74288C (en)
IT (1) IT1163796B (en)
PH (1) PH21033A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175150A (en) * 1985-08-31 1992-12-29 Kitasato, Kenkyusho Erythromycin derivative
US4876245A (en) * 1986-12-22 1989-10-24 Daikin Industries Ltd. Fluorine-containing macrolide compounds and their use
US5393743A (en) * 1993-07-06 1995-02-28 Abbott Laboratories Erythromycin derivatives
US5552533A (en) * 1994-09-14 1996-09-03 Alliedsignal Inc. Preparation of (8S)-8-fluoroerythromycins with N-F fluorinating agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0056291B1 (en) * 1981-01-09 1986-01-08 Pierrel S.p.A. Novel semisynthetic macrolidic antibiotics, microbiological processes for their preparation and related microorganism, novel intermediate compounds for their preparation and related pharmaceutical compositions containing them
IT1195299B (en) * 1981-11-27 1988-10-12 Pierrel Spa SYNTHESIS CHEMICAL PROCEDURE FOR THE PREPARATION OF MACROLIDIC ANTIBIOTICS

Also Published As

Publication number Publication date
IT8322104A1 (en) 1985-01-18
JPH0566396B2 (en) 1993-09-21
KR850001228A (en) 1985-03-16
FI74288C (en) 1988-01-11
KR910008110B1 (en) 1991-10-10
FI842894A0 (en) 1984-07-18
EP0135207A1 (en) 1985-03-27
US4673736A (en) 1987-06-16
PH21033A (en) 1987-06-30
DE3476804D1 (en) 1989-03-30
JPS6038394A (en) 1985-02-27
CA1223253A (en) 1987-06-23
EP0135207B1 (en) 1989-02-22
FI842894A (en) 1985-01-19
IT8322104A0 (en) 1983-07-18
IT1163796B (en) 1987-04-08
FI74288B (en) 1987-09-30

Similar Documents

Publication Publication Date Title
DE69101775D1 (en) Process for the production of hydrogen peroxide.
DE3587868D1 (en) Process for the production of aerogels.
ATE44735T1 (en) PROCESS FOR THE PRODUCTION OF (THREO)-1-ARYL-2ACYLAMIDO-3-FLUORO-1-PROPANOLS.
DE3788248D1 (en) Process for the production of chlorine.
DE3583218D1 (en) METHOD FOR PRODUCING CHLORINE.
AT371795B (en) METHOD FOR THE PRODUCTION OF TERT.OLEFINES
DE3584539D1 (en) METHOD FOR THE PRODUCTION OF CARBON FIBERS.
ATE7011T1 (en) PROCESS FOR THE PRODUCTION OF HYDROGEN PEROXIDE.
ATE40893T1 (en) PROCESS FOR THE PRODUCTION OF (8S)-8FLUOROERYTHROMYCINS.
DE69023991D1 (en) Process for the production of chlorotrifluoroethylene.
ATE1665T1 (en) PROCESS FOR THE PRODUCTION OF CHLORINE DIOXIDE.
ATE11521T1 (en) PROCESS FOR THE PRODUCTION OF HYDROGEN CYAN.
ATE67986T1 (en) PROCESS FOR THE PRODUCTION OF HYDROGEN PEROXIDE.
ATE21508T1 (en) PROCESS FOR THE PRODUCTION OF ALPHAHALOALKYLAMIDES.
DE3481508D1 (en) METHOD FOR THE PRODUCTION OF OPTICAL FIBERS.
DE68920358D1 (en) Process for the production of hydrogen sulfide.
DE58906807D1 (en) Process for the production of partially fluorinated ethanes.
DE3574584D1 (en) METHOD FOR THE PRODUCTION OF FLUORINATED CHINONES.
ATE10289T1 (en) PROCESS FOR THE PRODUCTION OF NARASIN.
DE3575556D1 (en) METHOD FOR THE PRODUCTION OF 2-PHENYLBENZTRIAZOLES.
DE69105628D1 (en) Process for the production of chlorate.
ATE30580T1 (en) PROCESS FOR THE PRODUCTION OF 1,1,2-TRICHLORO-2METHYL-PROPANE.
ATE30145T1 (en) PROCESS FOR THE PRODUCTION OF 3,3-DICHLORO-2METHYL-PROPEN.
ATE42090T1 (en) PROCESS FOR THE MANUFACTURE OF TAMOXIFEN.
ATE38826T1 (en) PROCESS FOR THE PRODUCTION OF ETHERS.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time