ATE407T1 - 4-PHENYL-THIAZOLYL-2-OXAMAT DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE IN THE TREATMENT OF ASTHMA. - Google Patents

4-PHENYL-THIAZOLYL-2-OXAMAT DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE IN THE TREATMENT OF ASTHMA.

Info

Publication number
ATE407T1
ATE407T1 AT79400293T AT79400293T ATE407T1 AT E407 T1 ATE407 T1 AT E407T1 AT 79400293 T AT79400293 T AT 79400293T AT 79400293 T AT79400293 T AT 79400293T AT E407 T1 ATE407 T1 AT E407T1
Authority
AT
Austria
Prior art keywords
thiazolyl
asthma
phenyl
treatment
derivatives
Prior art date
Application number
AT79400293T
Other languages
German (de)
Inventor
Henri Cousse
Gilbert Mouzin
Jean-Pierre Tarayre
Silvano Casadio
Original Assignee
Pierre Fabre S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre S.A. filed Critical Pierre Fabre S.A.
Application granted granted Critical
Publication of ATE407T1 publication Critical patent/ATE407T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

The present invention relates to new derivatives of 4-phenyl-2-thiazolyl oxamates having the formula: <IMAGE> in which: X represents hydrogen, halogen, lower-alkyl, or lower-alkoxy. R is lower-alkyl or phenyllower-alkyl, e.g., benzyl. These compounds, which have inhibiting properties on the passive cutaneous anaphylactic reaction, are useful in the treatment of asthma. Pharmaceutical compositions thereof and method of treating therewith.
AT79400293T 1978-06-19 1979-05-09 4-PHENYL-THIAZOLYL-2-OXAMAT DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE IN THE TREATMENT OF ASTHMA. ATE407T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7818500A FR2429210A1 (en) 1978-06-19 1978-06-19 PHENYL-4 THIAZOLYL-2 OXAMATE DERIVATIVES USEFUL IN THE TREATMENT OF ASTHMA
EP79400293A EP0006368B1 (en) 1978-06-19 1979-05-09 4-phenyl-thiazolyl-2-oxamate derivatives, their preparation and their use in the treatment of asthma

Publications (1)

Publication Number Publication Date
ATE407T1 true ATE407T1 (en) 1981-12-15

Family

ID=9209775

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79400293T ATE407T1 (en) 1978-06-19 1979-05-09 4-PHENYL-THIAZOLYL-2-OXAMAT DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE IN THE TREATMENT OF ASTHMA.

Country Status (8)

Country Link
US (1) US4246271A (en)
EP (1) EP0006368B1 (en)
JP (1) JPS552684A (en)
AT (1) ATE407T1 (en)
CA (1) CA1231952A (en)
DE (1) DE2961352D1 (en)
ES (1) ES481633A1 (en)
FR (1) FR2429210A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2828091A1 (en) * 1978-06-27 1980-01-10 Boehringer Sohn Ingelheim 4-SUBSTITUTED THIAZOLOXAMIC ACIDS AND THEIR SALTS AND ESTERS
US4321372A (en) * 1980-06-16 1982-03-23 Pfizer Inc. Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides
DE3027527A1 (en) * 1980-07-19 1982-02-18 Basf Ag, 6700 Ludwigshafen NEW OXAMID ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THERAPEUTIC AGENTS CONTAINING THEM
FR2494272A1 (en) * 1980-11-19 1982-05-21 Fabre Sa Pierre THIAZOLYL-2 OXAMIC ACID DERIVATIVES SUBSTITUTED IN POSITION 4 BY A THIENYL OR FURYL RADICAL, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
DE3135250A1 (en) * 1981-09-05 1983-03-17 Basf Ag, 6700 Ludwigshafen TRICYCLIC THIAZOLYLOXAMATES, METHOD FOR THE PRODUCTION THEREOF AND THERAPEUTIC AGENTS CONTAINING THEM
IT1183061B (en) * 1984-07-31 1987-10-05 Zambon Spa COMPOUNDS EQUIPPED WITH ANTI-ALLERGIC ACTIVITY
DE3503773A1 (en) * 1985-02-05 1986-08-07 Basf Ag, 6700 Ludwigshafen THIAZOLYLAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CONTROLLING UNWANTED PLANT GROWTH
IT1204960B (en) * 1987-03-25 1989-03-10 Zambon Farmaceutici Spa COMPOUNDS EQUIPPED WITH ANTIALLERGIC ACTIVITY
DE3807232A1 (en) * 1988-03-05 1989-09-14 Bayer Ag SUBSTITUTED ACRYLIC ACID ESTERS
JPH0667836B2 (en) * 1989-03-01 1994-08-31 東洋紡績株式会社 Antiallergic agent consisting of amide compounds
FR2671552B1 (en) * 1991-01-15 1993-05-07 Pf Medicament PROCESS FOR THE PREPARATION OF ALKYL OXAMATE THIAZOLYL-2.
WO1993000342A1 (en) * 1991-06-21 1993-01-07 Boehringer Mannheim Italia S.P.A. 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract
JP2510110B2 (en) * 1992-04-07 1996-06-26 日本航空電子工業株式会社 Method for manufacturing conductor for electronic component
WO2000076513A1 (en) * 1999-06-11 2000-12-21 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
MY156407A (en) * 2002-02-28 2016-02-26 Novartis Ag 5-phenylthiazole derivatives and use as p13 kinase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH486481A (en) * 1965-03-05 1970-02-28 Ciba Geigy Process for the preparation of new nitrothiazole compounds
US4054666A (en) * 1973-03-23 1977-10-18 American Home Products Corporation Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives
US3966965A (en) * 1973-03-23 1976-06-29 American Home Products Corporation Oxamic acid derivatives for the prevention of immediate type hypersensitivity reactions

Also Published As

Publication number Publication date
JPS552684A (en) 1980-01-10
EP0006368B1 (en) 1981-11-18
CA1231952A (en) 1988-01-26
US4246271A (en) 1981-01-20
ES481633A1 (en) 1980-02-16
FR2429210B1 (en) 1980-10-31
JPS6251272B2 (en) 1987-10-29
DE2961352D1 (en) 1982-01-21
EP0006368A1 (en) 1980-01-09
FR2429210A1 (en) 1980-01-18

Similar Documents

Publication Publication Date Title
ATE407T1 (en) 4-PHENYL-THIAZOLYL-2-OXAMAT DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE IN THE TREATMENT OF ASTHMA.
ATE128143T1 (en) 17-BETA-SUBSTITUTED-4-AZA-5-ALPHA-ANDROSTAN-3 ONE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF.
DE69723869D1 (en) HETEROCYCLIC COMPOUNDS, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEIR AND THEIR APPLICATION IN THE TREATMENT OF DIABETIS AND RELATED DISEASES
FI913478A0 (en) DIAZINDERIVAT.
ATE169622T1 (en) HETEROARYLAMINO AND HETEROARYLOXYPYRIDINAMINES AND RELATED COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
SE7907121L (en) FTALIMIDINDERIVAT
ATE68000T1 (en) BETA-D-PHENYL-THIOXYLOSIDES, PROCESSES FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE.
ES8201572A1 (en) 2-(1,4-Benzodioxanyl)-methoxy-propanol amines, process for their preparation and their use as medicines.
ATE324T1 (en) HYDROXYPROPYL-TRIAZOLES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS.
ATE290T1 (en) FLUORINE-CONTAINING 1,4-DIHYDROPYRIDINES, PHARMACEUTICALS CONTAINING THEM AND PROCESSES FOR THEIR MANUFACTURE.
AT375104B (en) METHOD FOR IMPREGNATING TREATMENT OF ORGANIC FIBERS AND ORGANOPOLYSILOXANIC COMPOSITIONS FOR CARRYING OUT THE METHOD
ES2109276T3 (en) TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF TO PREVENT AND TREAT ISCHEMIC DISEASES.
PT83309B (en) NEW PYRROLO-BENZIMIDAZOLE PYRROLO-BENZOXAZOLE AND PYRROLO-BENZTHIAZOLE METHOD FOR THE PRODUCTION THEREOF AND THESE COMPOUNDS CONTAINING SUBSTANCES
DE59403966D1 (en) HYDROXYMETHYLFURAZANIC CARBONIC ACID DERIVATIVES AND THEIR USE IN TREATING CARDIOVASCULAR DISEASES
ATE4117T1 (en) PSEUDOTRISACCHARIDES, THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS.
ATE2794T1 (en) 1-N-ALKYLSISOMICIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS.
FR2396015A1 (en) ACETYLENE DERIVATIVES, THEIR PROCESS FOR PREPARATION AND THEIR USE AS MONOAMINE OXIDASE INHIBITORS FOR TREATING IN PARTICULAR DEPRESSIVE STATE OR HYPERTENSION
ATE206105T1 (en) ALKYKENEDIAMINE DI-OR TRI-ACETIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN COSMETIC COMPOSITIONS
ATE8389T1 (en) AMINO-ALKOXY-PYRAZOLE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM.
ATE28858T1 (en) DERIVATIVES OF N-(METHOXYPHENACYL)AMINES, THEIR THERAPEUTIC USE AND PROCESS FOR THEIR PRODUCTION.
ATE14124T1 (en) RING-SHAPED SULPHENAMIDES, PROCESS FOR THEIR MANUFACTURE, MEDICATIONS CONTAINING THEM AND THEIR MANUFACTURE.
DE68902627T2 (en) USE OF CHROME DERIVATIVES FOR PRODUCING A MEDICINAL PRODUCT FOR TREATING DEPRESSIVE STATES.
ATE119149T1 (en) PYRROLIDONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THEM.
HUP0001118A2 (en) N-substituted pyrrolidine derivatives, process for preparing the same and pharmaceutical compositions containing them
ATE879T1 (en) CYCLOPHOSPHATHIAZENE, PROCESS FOR THEIR PREPARATION AND AGENTS CONTAINING THEM.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee