ATE407T1 - 4-PHENYL-THIAZOLYL-2-OXAMAT DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE IN THE TREATMENT OF ASTHMA. - Google Patents
4-PHENYL-THIAZOLYL-2-OXAMAT DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE IN THE TREATMENT OF ASTHMA.Info
- Publication number
- ATE407T1 ATE407T1 AT79400293T AT79400293T ATE407T1 AT E407 T1 ATE407 T1 AT E407T1 AT 79400293 T AT79400293 T AT 79400293T AT 79400293 T AT79400293 T AT 79400293T AT E407 T1 ATE407 T1 AT E407T1
- Authority
- AT
- Austria
- Prior art keywords
- thiazolyl
- asthma
- phenyl
- treatment
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
The present invention relates to new derivatives of 4-phenyl-2-thiazolyl oxamates having the formula: <IMAGE> in which: X represents hydrogen, halogen, lower-alkyl, or lower-alkoxy. R is lower-alkyl or phenyllower-alkyl, e.g., benzyl. These compounds, which have inhibiting properties on the passive cutaneous anaphylactic reaction, are useful in the treatment of asthma. Pharmaceutical compositions thereof and method of treating therewith.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7818500A FR2429210A1 (en) | 1978-06-19 | 1978-06-19 | PHENYL-4 THIAZOLYL-2 OXAMATE DERIVATIVES USEFUL IN THE TREATMENT OF ASTHMA |
EP79400293A EP0006368B1 (en) | 1978-06-19 | 1979-05-09 | 4-phenyl-thiazolyl-2-oxamate derivatives, their preparation and their use in the treatment of asthma |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE407T1 true ATE407T1 (en) | 1981-12-15 |
Family
ID=9209775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT79400293T ATE407T1 (en) | 1978-06-19 | 1979-05-09 | 4-PHENYL-THIAZOLYL-2-OXAMAT DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE IN THE TREATMENT OF ASTHMA. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4246271A (en) |
EP (1) | EP0006368B1 (en) |
JP (1) | JPS552684A (en) |
AT (1) | ATE407T1 (en) |
CA (1) | CA1231952A (en) |
DE (1) | DE2961352D1 (en) |
ES (1) | ES481633A1 (en) |
FR (1) | FR2429210A1 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2828091A1 (en) * | 1978-06-27 | 1980-01-10 | Boehringer Sohn Ingelheim | 4-SUBSTITUTED THIAZOLOXAMIC ACIDS AND THEIR SALTS AND ESTERS |
US4321372A (en) * | 1980-06-16 | 1982-03-23 | Pfizer Inc. | Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides |
DE3027527A1 (en) * | 1980-07-19 | 1982-02-18 | Basf Ag, 6700 Ludwigshafen | NEW OXAMID ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THERAPEUTIC AGENTS CONTAINING THEM |
FR2494272A1 (en) * | 1980-11-19 | 1982-05-21 | Fabre Sa Pierre | THIAZOLYL-2 OXAMIC ACID DERIVATIVES SUBSTITUTED IN POSITION 4 BY A THIENYL OR FURYL RADICAL, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS |
DE3135250A1 (en) * | 1981-09-05 | 1983-03-17 | Basf Ag, 6700 Ludwigshafen | TRICYCLIC THIAZOLYLOXAMATES, METHOD FOR THE PRODUCTION THEREOF AND THERAPEUTIC AGENTS CONTAINING THEM |
IT1183061B (en) * | 1984-07-31 | 1987-10-05 | Zambon Spa | COMPOUNDS EQUIPPED WITH ANTI-ALLERGIC ACTIVITY |
DE3503773A1 (en) * | 1985-02-05 | 1986-08-07 | Basf Ag, 6700 Ludwigshafen | THIAZOLYLAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CONTROLLING UNWANTED PLANT GROWTH |
IT1204960B (en) * | 1987-03-25 | 1989-03-10 | Zambon Farmaceutici Spa | COMPOUNDS EQUIPPED WITH ANTIALLERGIC ACTIVITY |
DE3807232A1 (en) * | 1988-03-05 | 1989-09-14 | Bayer Ag | SUBSTITUTED ACRYLIC ACID ESTERS |
JPH0667836B2 (en) * | 1989-03-01 | 1994-08-31 | 東洋紡績株式会社 | Antiallergic agent consisting of amide compounds |
FR2671552B1 (en) * | 1991-01-15 | 1993-05-07 | Pf Medicament | PROCESS FOR THE PREPARATION OF ALKYL OXAMATE THIAZOLYL-2. |
JPH07502014A (en) * | 1991-06-21 | 1995-03-02 | ベーリンガー マンハイム イタリア エス.ピー.エイ. | 2-Amino-4-aryl-thiazoles with anti-asthmatic, anti-inflammatory activity on the respiratory tract |
JP2510110B2 (en) * | 1992-04-07 | 1996-06-26 | 日本航空電子工業株式会社 | Method for manufacturing conductor for electronic component |
WO2000076513A1 (en) * | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
TWI314928B (en) * | 2002-02-28 | 2009-09-21 | Novartis A | 5-phenylthiazole derivatives and use as pi3 kinase inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH486481A (en) * | 1965-03-05 | 1970-02-28 | Ciba Geigy | Process for the preparation of new nitrothiazole compounds |
US4054666A (en) * | 1973-03-23 | 1977-10-18 | American Home Products Corporation | Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives |
US3966965A (en) * | 1973-03-23 | 1976-06-29 | American Home Products Corporation | Oxamic acid derivatives for the prevention of immediate type hypersensitivity reactions |
-
1978
- 1978-06-19 FR FR7818500A patent/FR2429210A1/en active Granted
-
1979
- 1979-05-09 EP EP79400293A patent/EP0006368B1/en not_active Expired
- 1979-05-09 DE DE7979400293T patent/DE2961352D1/en not_active Expired
- 1979-05-09 AT AT79400293T patent/ATE407T1/en not_active IP Right Cessation
- 1979-06-14 US US06/048,371 patent/US4246271A/en not_active Expired - Lifetime
- 1979-06-18 ES ES481633A patent/ES481633A1/en not_active Expired
- 1979-06-19 JP JP7638779A patent/JPS552684A/en active Granted
- 1979-06-19 CA CA000330121A patent/CA1231952A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2429210B1 (en) | 1980-10-31 |
FR2429210A1 (en) | 1980-01-18 |
JPS6251272B2 (en) | 1987-10-29 |
EP0006368A1 (en) | 1980-01-09 |
US4246271A (en) | 1981-01-20 |
DE2961352D1 (en) | 1982-01-21 |
JPS552684A (en) | 1980-01-10 |
ES481633A1 (en) | 1980-02-16 |
EP0006368B1 (en) | 1981-11-18 |
CA1231952A (en) | 1988-01-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |