ATE386722T1 - AN IMPROVED METHOD FOR THE SYNTHESIS OF METHYLPHENIDATES AND INTERMEDIATE PRODUCTS - Google Patents

AN IMPROVED METHOD FOR THE SYNTHESIS OF METHYLPHENIDATES AND INTERMEDIATE PRODUCTS

Info

Publication number
ATE386722T1
ATE386722T1 AT05253597T AT05253597T ATE386722T1 AT E386722 T1 ATE386722 T1 AT E386722T1 AT 05253597 T AT05253597 T AT 05253597T AT 05253597 T AT05253597 T AT 05253597T AT E386722 T1 ATE386722 T1 AT E386722T1
Authority
AT
Austria
Prior art keywords
methylphenidates
synthesis
improved method
intermediate products
substituted
Prior art date
Application number
AT05253597T
Other languages
German (de)
Inventor
Ashok Kumar
Dharmendra Shing
Swapnali Hemant Patil
Ganesh Devidas Mahale
Uttamrao Arjunrao Sawant
Original Assignee
Ipca Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipca Lab Ltd filed Critical Ipca Lab Ltd
Application granted granted Critical
Publication of ATE386722T1 publication Critical patent/ATE386722T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

The present invention discloses selective and complete reduction of pyridine ring in a biaryl system comprising alpha -substituted or non-substituted benzene ringand relates more specifically, not exclusively, for the manufacture of methylphenidate, which is used for treatment of Attention Deficit Hyperactive Disorder (ADHD) and also acts as central nervous system stimulant, by using palladium/C in a solvent such as C1-C4 alcohols in presence of molar quantities of organic and/or inorganic acids. <CHEM>
AT05253597T 2004-06-15 2005-06-10 AN IMPROVED METHOD FOR THE SYNTHESIS OF METHYLPHENIDATES AND INTERMEDIATE PRODUCTS ATE386722T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN651MU2004 2004-06-15

Publications (1)

Publication Number Publication Date
ATE386722T1 true ATE386722T1 (en) 2008-03-15

Family

ID=34978625

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05253597T ATE386722T1 (en) 2004-06-15 2005-06-10 AN IMPROVED METHOD FOR THE SYNTHESIS OF METHYLPHENIDATES AND INTERMEDIATE PRODUCTS

Country Status (5)

Country Link
US (1) US7459467B2 (en)
EP (1) EP1607388B1 (en)
AT (1) ATE386722T1 (en)
DE (1) DE602005004834T2 (en)
ES (1) ES2302145T3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897777B2 (en) * 2007-01-05 2011-03-01 Archimica, Inc. Process of enantiomeric resolution of D,L-(±)-threo-methylphenidate
US9512077B2 (en) * 2013-08-14 2016-12-06 Zcl Chemicals Ltd. Process for the preparation of methylphenidate hydrochloride and its intermediates thereof
KR101969407B1 (en) 2017-09-12 2019-08-20 한국화학연구원 The Selective Hydrogenation Catalyst and Selective Hydrogenation Process using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507631A (en) 1944-01-19 1950-05-16 Ciba Pharm Prod Inc Pyridine and piperidine compounds and process of making same
US2957880A (en) 1953-12-23 1960-10-25 Ciba Pharm Prod Inc Process for the conversion of stereoisomers

Also Published As

Publication number Publication date
EP1607388B1 (en) 2008-02-20
DE602005004834D1 (en) 2008-04-03
US20050277667A1 (en) 2005-12-15
DE602005004834T2 (en) 2009-02-19
ES2302145T3 (en) 2008-07-01
US7459467B2 (en) 2008-12-02
EP1607388A1 (en) 2005-12-21

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