ATE386718T1 - METHOD FOR PRODUCING (2S, 3AR, 7AS)-OCTAHYDROINDOLE-2-CARBONIC ACID AND CONVERSION TO TRANDOLAPRIL - Google Patents

METHOD FOR PRODUCING (2S, 3AR, 7AS)-OCTAHYDROINDOLE-2-CARBONIC ACID AND CONVERSION TO TRANDOLAPRIL

Info

Publication number
ATE386718T1
ATE386718T1 AT05076060T AT05076060T ATE386718T1 AT E386718 T1 ATE386718 T1 AT E386718T1 AT 05076060 T AT05076060 T AT 05076060T AT 05076060 T AT05076060 T AT 05076060T AT E386718 T1 ATE386718 T1 AT E386718T1
Authority
AT
Austria
Prior art keywords
octahydroindole
trandolapril
conversion
producing
carbonic acid
Prior art date
Application number
AT05076060T
Other languages
German (de)
Inventor
Haider Akhtar
Babu Potluri Ramesh
Subhramanian Hariharak Venkata
Prassad Kodali Hari
Original Assignee
Sochinaz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sochinaz Sa filed Critical Sochinaz Sa
Application granted granted Critical
Publication of ATE386718T1 publication Critical patent/ATE386718T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

The present invention describes a novel method for the synthesis of (2S,3aR,7aS)-octahydroindole-2-carboxylic acid of formula III using a new intermediate of formula II and conversion of the product of formula-III to trandolapril of formula I
AT05076060T 2005-05-06 2005-05-06 METHOD FOR PRODUCING (2S, 3AR, 7AS)-OCTAHYDROINDOLE-2-CARBONIC ACID AND CONVERSION TO TRANDOLAPRIL ATE386718T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05076060A EP1724260B1 (en) 2005-05-06 2005-05-06 Process for the synthesis of (2S, 3aR, 7aS)octahydroindole-2-carboxylic acid and its conversion to trandolapril

Publications (1)

Publication Number Publication Date
ATE386718T1 true ATE386718T1 (en) 2008-03-15

Family

ID=34979532

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05076060T ATE386718T1 (en) 2005-05-06 2005-05-06 METHOD FOR PRODUCING (2S, 3AR, 7AS)-OCTAHYDROINDOLE-2-CARBONIC ACID AND CONVERSION TO TRANDOLAPRIL

Country Status (3)

Country Link
EP (1) EP1724260B1 (en)
AT (1) ATE386718T1 (en)
DE (1) DE602005004897D1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2012103753A (en) 2009-07-16 2013-08-27 Эбботт Лабораториз METHOD FOR SYNTHESIS (2S, 3AR, 7AS) -OKTAGHYDRO-1H-INDOL-CARBOXYLIC ACID AS AN INTERMEDIATE COMPOUND FOR PRODUCTION OF TRANDOLAPRIL
WO2023098640A1 (en) * 2021-11-30 2023-06-08 浙江华海药业股份有限公司 Preparation method for drug intermediate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78413B (en) * 1981-12-29 1984-09-27 Hoechst Ag

Also Published As

Publication number Publication date
DE602005004897D1 (en) 2008-04-03
EP1724260B1 (en) 2008-02-20
EP1724260A1 (en) 2006-11-22

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