ATE36331T1 - GUANINE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND THEIR ANTIVIRAL ACTIVITIES. - Google Patents
GUANINE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND THEIR ANTIVIRAL ACTIVITIES.Info
- Publication number
- ATE36331T1 ATE36331T1 AT84301089T AT84301089T ATE36331T1 AT E36331 T1 ATE36331 T1 AT E36331T1 AT 84301089 T AT84301089 T AT 84301089T AT 84301089 T AT84301089 T AT 84301089T AT E36331 T1 ATE36331 T1 AT E36331T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions containing
- antiviral activities
- guanine derivatives
- infections
- acid
- Prior art date
Links
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 title 1
- XUYJLQHKOGNDPB-UHFFFAOYSA-N phosphonoacetic acid Chemical compound OC(=O)CP(O)(O)=O XUYJLQHKOGNDPB-UHFFFAOYSA-N 0.000 abstract 2
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 abstract 2
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 1
- 229960005102 foscarnet Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
Abstract
2-(N,N-dialkylaminomethylene)-9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl] guanines and their salts are of utility in the treatment of viral infections, and in particular for combatting herpes virus type 1 infections. They may be formulated in compositions together with an interferon, phosphonoformic acid or phosphonoacetic acid, for synergic activity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/468,877 US4461757A (en) | 1983-02-23 | 1983-02-23 | Dimethylaminomethylenated anti-herpes compounds |
| EP84301089A EP0119757B1 (en) | 1983-02-23 | 1984-02-20 | Guanine derivatives, compositions containing them, and their anti-viral use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE36331T1 true ATE36331T1 (en) | 1988-08-15 |
Family
ID=23861607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84301089T ATE36331T1 (en) | 1983-02-23 | 1984-02-20 | GUANINE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND THEIR ANTIVIRAL ACTIVITIES. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4461757A (en) |
| EP (1) | EP0119757B1 (en) |
| JP (1) | JPS59186985A (en) |
| AT (1) | ATE36331T1 (en) |
| AU (1) | AU2462284A (en) |
| CA (1) | CA1225641A (en) |
| DE (1) | DE3473272D1 (en) |
| DK (1) | DK79784A (en) |
| MC (1) | MC1575A1 (en) |
| ZA (1) | ZA841241B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4849411A (en) * | 1982-11-09 | 1989-07-18 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
| US5147636A (en) * | 1982-11-09 | 1992-09-15 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives and interferons |
| US4565868A (en) * | 1983-02-07 | 1986-01-21 | Syntex (U.S.A.) Inc. | Process for preparing guanine derivatives |
| US5684153A (en) * | 1984-08-16 | 1997-11-04 | Beecham Group Plc | Process for the preparation of purine derivatives |
| DE3485225D1 (en) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | ANTIVIRAL GUANINE DERIVATIVES. |
| US4579849A (en) * | 1984-04-06 | 1986-04-01 | Merck & Co., Inc. | N-alkylguanine acyclonucleosides as antiviral agents |
| US4636383A (en) * | 1984-08-29 | 1987-01-13 | Schering Corporation | Interferon-cyclaradine combination |
| IL76591A0 (en) | 1984-10-05 | 1986-02-28 | Bioferon Biochem Substanz | Pharmaceutical compositions containing ifn-ypsilon and processes for the preparation thereof |
| GB8628826D0 (en) * | 1986-12-02 | 1987-01-07 | Beecham Group Plc | Pharmaceutical products |
| GB8813032D0 (en) * | 1988-06-02 | 1988-07-06 | Boehringer Ingelheim Int | Antiviral pharmaceutical composition |
| US5840763A (en) * | 1994-12-12 | 1998-11-24 | Smithkline Beecham Plc | Treatment of a latent infection of herpes viruses |
| US20040002079A1 (en) * | 1998-02-11 | 2004-01-01 | Gunn Robert B. | Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness |
| WO2013023362A1 (en) * | 2011-08-16 | 2013-02-21 | 深圳市卫武光明生物制品有限公司 | Cytomegalovirus human immunoglobulin for intravenous injection, and preparation method therefor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
| US4347360A (en) * | 1980-09-16 | 1982-08-31 | Ens Bio Logicals Inc. | Ring open nucleoside analogues |
| US4355032B2 (en) * | 1981-05-21 | 1990-10-30 | 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent |
-
1983
- 1983-02-23 US US06/468,877 patent/US4461757A/en not_active Expired - Fee Related
-
1984
- 1984-02-15 AU AU24622/84A patent/AU2462284A/en not_active Abandoned
- 1984-02-20 MC MC841694A patent/MC1575A1/en unknown
- 1984-02-20 EP EP84301089A patent/EP0119757B1/en not_active Expired
- 1984-02-20 AT AT84301089T patent/ATE36331T1/en not_active IP Right Cessation
- 1984-02-20 DK DK79784A patent/DK79784A/en unknown
- 1984-02-20 DE DE8484301089T patent/DE3473272D1/en not_active Expired
- 1984-02-21 ZA ZA841241A patent/ZA841241B/en unknown
- 1984-02-22 CA CA000447985A patent/CA1225641A/en not_active Expired
- 1984-02-23 JP JP59031549A patent/JPS59186985A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2462284A (en) | 1984-08-30 |
| US4461757A (en) | 1984-07-24 |
| DE3473272D1 (en) | 1988-09-15 |
| JPS59186985A (en) | 1984-10-23 |
| EP0119757B1 (en) | 1988-08-10 |
| EP0119757A3 (en) | 1985-08-28 |
| CA1225641A (en) | 1987-08-18 |
| DK79784D0 (en) | 1984-02-20 |
| DK79784A (en) | 1984-08-24 |
| MC1575A1 (en) | 1985-02-04 |
| ZA841241B (en) | 1984-12-24 |
| EP0119757A2 (en) | 1984-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |