ATE350T1 - PROCESS FOR THE PREPARATION OF AROMATIC 2-HYDROXY-3-ISOPROPYL OR 2-HYDROXY-3-TERT-BUTYLAMINOPROPYL AETHERS. - Google Patents

PROCESS FOR THE PREPARATION OF AROMATIC 2-HYDROXY-3-ISOPROPYL OR 2-HYDROXY-3-TERT-BUTYLAMINOPROPYL AETHERS.

Info

Publication number
ATE350T1
ATE350T1 AT79102949T AT79102949T ATE350T1 AT E350 T1 ATE350 T1 AT E350T1 AT 79102949 T AT79102949 T AT 79102949T AT 79102949 T AT79102949 T AT 79102949T AT E350 T1 ATE350 T1 AT E350T1
Authority
AT
Austria
Prior art keywords
hydroxy
tert
isopropyl
butylaminopropyl
aromatic
Prior art date
Application number
AT79102949T
Other languages
German (de)
Inventor
David Samuel Kirkpatrick
Robert Lee Webb
Original Assignee
Smithkline Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corporation filed Critical Smithkline Corporation
Application granted granted Critical
Publication of ATE350T1 publication Critical patent/ATE350T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Epoxy Resins (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Casting Devices For Molds (AREA)

Abstract

Methods and intermediates for introducing the two blocking side chains, 2-hydroxy- 3-isopropyl or tert.-butylaminopropyl, into aromatic nuclei containing a phenolic hydroxyl group by condensing a 5-halomethyl-3-isopropyl or 3-tert. -butyl-2-oxazolidinone with an aromatic compound containing a phenolic hydroxy group in the presence of an acid binding agent at 80-150 DEG C then subsquently splitting the oxazolidinone ring using an alkali metal hydroxide or lower alkoxide at a temperature in the range of 100-150 DEG C in an organic solvent.
AT79102949T 1978-08-15 1979-08-13 PROCESS FOR THE PREPARATION OF AROMATIC 2-HYDROXY-3-ISOPROPYL OR 2-HYDROXY-3-TERT-BUTYLAMINOPROPYL AETHERS. ATE350T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93392378A 1978-08-15 1978-08-15
EP79102949A EP0008711B1 (en) 1978-08-15 1979-08-13 A method of preparing a 2-hydroxy-3-isopropyl or a 2-hydroxy-3-tert-butylaminopropyl aromatic ether

Publications (1)

Publication Number Publication Date
ATE350T1 true ATE350T1 (en) 1981-11-15

Family

ID=25464688

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79102949T ATE350T1 (en) 1978-08-15 1979-08-13 PROCESS FOR THE PREPARATION OF AROMATIC 2-HYDROXY-3-ISOPROPYL OR 2-HYDROXY-3-TERT-BUTYLAMINOPROPYL AETHERS.

Country Status (6)

Country Link
EP (1) EP0008711B1 (en)
JP (1) JPS5528984A (en)
AT (1) ATE350T1 (en)
DE (1) DE2961251D1 (en)
IE (1) IE48804B1 (en)
IT (1) IT1118835B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58148145A (en) * 1982-02-24 1983-09-03 Hakugen:Kk Pulling tension adjustor for wound films

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH481873A (en) * 1965-09-09 1969-11-30 Ciba Geigy Process for the preparation of a new amine
GB1307405A (en) * 1969-04-14 1973-02-21 Sankyo Chem Ind Ltd Process for preparing 5-aryloxy methyl-oxazolidine and alkylamino alcohol derivatives
DE2538424C2 (en) * 1975-08-29 1983-01-05 Nordmark-Werke Gmbh, 2000 Hamburg 4-substituted 5-phenyl-oxazolidone- (2) - compounds and a pharmaceutical preparation containing them
DE2623314C2 (en) * 1976-05-25 1984-08-02 Hoechst Ag, 6230 Frankfurt 1-aryloxy-2-hydroxy-3-aminopropanes, processes for their preparation and pharmaceuticals containing them

Also Published As

Publication number Publication date
IT1118835B (en) 1986-03-03
IE791566L (en) 1980-02-15
EP0008711B1 (en) 1981-11-04
EP0008711A1 (en) 1980-03-19
DE2961251D1 (en) 1982-01-14
IE48804B1 (en) 1985-05-15
JPS5528984A (en) 1980-02-29
IT7968668A0 (en) 1979-08-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee