ATE349231T1 - ADHESIVE CONTAINING MEDICATION - Google Patents

ADHESIVE CONTAINING MEDICATION

Info

Publication number
ATE349231T1
ATE349231T1 AT02752500T AT02752500T ATE349231T1 AT E349231 T1 ATE349231 T1 AT E349231T1 AT 02752500 T AT02752500 T AT 02752500T AT 02752500 T AT02752500 T AT 02752500T AT E349231 T1 ATE349231 T1 AT E349231T1
Authority
AT
Austria
Prior art keywords
matrix
cyanoacrylate
adhesive containing
substance
forming agent
Prior art date
Application number
AT02752500T
Other languages
German (de)
Inventor
Yong-Hua Zhu
Chang Zheng Yang
Qun-Dong Shen
Wolff M Kirsch
Cindy Dickson
Min Di Gu
Original Assignee
Univ Loma Linda Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Loma Linda Med filed Critical Univ Loma Linda Med
Application granted granted Critical
Publication of ATE349231T1 publication Critical patent/ATE349231T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • A61B17/085—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound with adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A61F13/0246—Adhesive plasters or dressings characterised by the skin adhering layer
    • A61F13/0253—Adhesive plasters or dressings characterised by the skin adhering layer characterized by the adhesive material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • A61B2017/081—Tissue approximator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Abstract

The present invention provides medicament-containing cyanoacrylate adhesive formulations for sealing wounds. The adhesive comprises a cyanoacrylate, a substance, and a defect forming agent, wherein the defect forming agent is capable of being removed from a cured cyanoacrylate matrix by solvation in an aqueous solution whereby a plurality of defects in the matrix are formed permitting release of the substance from the matrix at a controlled rate.
AT02752500T 2001-07-19 2002-07-19 ADHESIVE CONTAINING MEDICATION ATE349231T1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30657201P 2001-07-19 2001-07-19
US30899301P 2001-07-31 2001-07-31
US33766201P 2001-11-07 2001-11-07
US34159801P 2001-12-17 2001-12-17
US10/041,688 US20030044380A1 (en) 2001-07-19 2002-01-07 Adhesive including medicament

Publications (1)

Publication Number Publication Date
ATE349231T1 true ATE349231T1 (en) 2007-01-15

Family

ID=27534768

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02752500T ATE349231T1 (en) 2001-07-19 2002-07-19 ADHESIVE CONTAINING MEDICATION
AT06026474T ATE513567T1 (en) 2001-07-19 2002-07-19 ADHESIVE CONTAINING MEDICATION

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06026474T ATE513567T1 (en) 2001-07-19 2002-07-19 ADHESIVE CONTAINING MEDICATION

Country Status (8)

Country Link
US (1) US20030044380A1 (en)
EP (2) EP1803473B1 (en)
AT (2) ATE349231T1 (en)
CA (1) CA2453620C (en)
DE (1) DE60217121T2 (en)
ES (2) ES2368439T3 (en)
FR (1) FR1409033T (en)
WO (1) WO2003008003A1 (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE480186T1 (en) 2000-02-24 2010-09-15 Univ Loma Linda Med PLASTER AND ADHESIVE DELIVERY SYSTEM FOR CLOSING A TISSUE OPENING DURING SURGICAL TREATMENT
US6890342B2 (en) 2000-08-02 2005-05-10 Loma Linda University Method and apparatus for closing vascular puncture using hemostatic material
US6974592B2 (en) * 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
EP1513456B1 (en) * 2002-06-14 2006-10-11 Loma Linda University Medical Center Vascular wound closure device
MX272648B (en) * 2002-11-04 2009-12-10 Ocean Nutrition Canada Ltd Microcapsules having multiple shells and method for the preparation thereof.
GB0227043D0 (en) * 2002-11-20 2002-12-24 Smith & Nephew Angiogenic medical cyanoacrylate
WO2004084963A1 (en) * 2003-03-25 2004-10-07 Smith & Nephew, Plc Porous medical adhesive comprising cyanonacrylate
AU2004253463B2 (en) * 2003-06-16 2010-12-09 Loma Linda University Medical Center Deployable multifunctional hemostatic agent
ATE502580T1 (en) 2003-08-14 2011-04-15 Univ Loma Linda Med DEVICE FOR CLOSING VESSEL WOUNDS
US8187627B2 (en) 2003-09-05 2012-05-29 Loma Linda University Medical Center Dressing delivery system for internal wounds
US7758939B2 (en) 2004-01-08 2010-07-20 Marchitto Kevin S Adhesive laminates for rapid wound occlusion
US8034450B2 (en) * 2005-01-21 2011-10-11 Ocean Nutrition Canada Limited Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
US20080206316A1 (en) * 2005-01-27 2008-08-28 Colin Barrow Chromium-Fatty Acid Compounds and Methods of Making and Using Thereof
CA2596023A1 (en) * 2005-01-27 2006-11-09 Ocean Nutrition Canada Ltd. Fatty acid-benzenediol derivatives and methods of making and using thereof
US20060251612A1 (en) * 2005-05-09 2006-11-09 Dimiter Kotzev Bioresorbable cyanoacrylate adhesives
US9968120B2 (en) * 2006-05-17 2018-05-15 Dsm Nutritional Products Ag Homogenized formulations containing microcapsules and methods of making and using thereof
DE602006020488D1 (en) 2005-10-05 2011-04-14 Univ Loma Linda Med Vascular wound closure device
AU2006321912B2 (en) * 2005-12-06 2012-07-12 Covidien Lp Carbodiimide crosslinking of functionalized polethylene glycols
CA2628575C (en) * 2005-12-06 2014-07-08 Tyco Healthcare Group Lp Biocompatible surgical compositions
CA2628580C (en) 2005-12-06 2014-07-08 Tyco Healthcare Group Lp Bioabsorbable compounds and compositions containing them
AU2006321913B2 (en) * 2005-12-06 2012-08-02 Covidien Lp Biocompatible tissue sealants and adhesives
AU2006321915B2 (en) * 2005-12-06 2012-04-26 Covidien Lp Bioabsorbable surgical composition
CA2630327C (en) * 2005-12-08 2015-05-26 Tyco Healthcare Group Lp Biocompatible surgical compositons
JP2009518138A (en) * 2005-12-08 2009-05-07 タイコ ヘルスケア グループ リミテッド パートナーシップ Biocompatible surgical composition
JP2009518522A (en) * 2005-12-08 2009-05-07 タイコ ヘルスケア グループ リミテッド パートナーシップ Sprayable composition with reduced viscosity
NZ572529A (en) * 2006-04-07 2010-11-26 Ocean Nutrition Canada Ltd Emulsions and microcapsules with substances having low interfacial tension, methods of making and using thereof
WO2007134215A2 (en) 2006-05-12 2007-11-22 Entrigue Surgical, Inc. Middle turbinate medializer
ITRM20060289A1 (en) * 2006-05-31 2007-12-01 Ranieri Cancedda BIO MEMBRANE ENGINEERED OSTEO ANGIOGENICA AND ITS USES FOR THE REGENERATION OF BONE FABRIC
JP5979697B2 (en) * 2006-06-05 2016-08-24 ディーエスエム ニュートリショナル プロダクツ アーゲーＤＳＭ Ｎｕｔｒｉｔｉｏｎａｌ Ｐｒｏｄｕｃｔｓ ＡＧ Microcapsules with improved shell
US20080109033A1 (en) * 2006-10-31 2008-05-08 Texas Heart Institute Method and device for prevention of pneumothorax during vascular access
TWI362925B (en) * 2006-11-09 2012-05-01 Kci Licensing Inc Method for preparing a bioresorbable dressing comprising bioresorbable microparticles and method for preparing a bioresorbable dressing comprising bioresorbable microspheres
US10166196B2 (en) 2007-01-10 2019-01-01 Dsm Nutritional Products Ag Vegetarian microcapsules
WO2010008822A2 (en) 2008-06-23 2010-01-21 Adhezion Biomedical, Llc Cyanoacrylate tissue adhesives with desirable permeability and tensile strength
US8729121B2 (en) * 2007-06-25 2014-05-20 Adhezion Biomedical, Llc Curing accelerator and method of making
US8672911B2 (en) 2007-08-03 2014-03-18 Kimberly-Clark Worldwide, Inc. Body adhering absorbent article
US7947027B2 (en) 2007-12-28 2011-05-24 Kimberly-Clark Worldwide, Inc. Body adhering absorbent article
US8734413B2 (en) 2007-08-03 2014-05-27 Kimberly-Clark Worldwide, Inc. Packaged body adhering absorbent article
WO2009060438A2 (en) * 2007-11-05 2009-05-14 Technion - Research & Development Foundation Ltd Adhering bandage and methods of applying the same
US8613952B2 (en) * 2007-11-14 2013-12-24 Adhezion Biomedical, Llc Cyanoacrylate tissue adhesives
US8293838B2 (en) * 2008-06-20 2012-10-23 Adhezion Biomedical, Llc Stable and sterile tissue adhesive composition with a controlled high viscosity
US8198344B2 (en) * 2008-06-20 2012-06-12 Adhezion Biomedical, Llc Method of preparing adhesive compositions for medical use: single additive as both the thickening agent and the accelerator
US8609128B2 (en) * 2008-10-31 2013-12-17 Adhezion Biomedical, Llc Cyanoacrylate-based liquid microbial sealant drape
US9254133B2 (en) 2008-10-31 2016-02-09 Adhezion Biomedical, Llc Sterilized liquid compositions of cyanoacrylate monomer mixtures
US8652510B2 (en) 2008-10-31 2014-02-18 Adhezion Biomedical, Llc Sterilized liquid compositions of cyanoacrylate monomer mixtures
US11147722B2 (en) * 2008-11-10 2021-10-19 Kimberly-Clark Worldwide, Inc. Absorbent article with a multifunctional acrylate skin-adhesive composition
GB2465610A (en) * 2008-11-25 2010-05-26 Ethicon Inc Medical adhesive composition comprising a alpha-cyanoacrylate monomer and a NSAID
ES2411972T5 (en) 2009-01-09 2021-10-27 Fwp Ip Aps Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
WO2010140146A2 (en) 2009-06-01 2010-12-09 Technion - Research & Development Foundation Ltd Sealants, manufacturing thereof, and applications thereof
US8221994B2 (en) * 2009-09-30 2012-07-17 Cilag Gmbh International Adhesive composition for use in an immunosensor
DE102010012521A1 (en) * 2010-03-17 2011-09-22 Aesculap Ag Medical kit for use in vacuum sealing therapy
US20110269844A1 (en) * 2010-05-03 2011-11-03 Innoteq, Inc. Thin film with propofol active ingredient
US9309019B2 (en) 2010-05-21 2016-04-12 Adhezion Biomedical, Llc Low dose gamma sterilization of liquid adhesives
SG177871A1 (en) * 2010-07-20 2012-02-28 Agency Science Tech & Res Method and apparatus for forming a porous biodegradable medical implant device
US9586306B2 (en) 2012-08-13 2017-03-07 Omax Corporation Method and apparatus for monitoring particle laden pneumatic abrasive flow in an abrasive fluid jet cutting system
WO2014126274A1 (en) * 2013-02-13 2014-08-21 주식회사 시지바이오 Biobinding agent composition comprising egf microspheres
US9090808B1 (en) * 2013-03-15 2015-07-28 Omax Corporation Abrasive materials for use in abrasive-jet systems and associated materials, apparatuses, systems, and methods
US9421297B2 (en) 2014-04-02 2016-08-23 Adhezion Biomedical, Llc Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
US11577366B2 (en) 2016-12-12 2023-02-14 Omax Corporation Recirculation of wet abrasive material in abrasive waterjet systems and related technology
US11224987B1 (en) 2018-03-09 2022-01-18 Omax Corporation Abrasive-collecting container of a waterjet system and related technology
US11452641B2 (en) 2019-06-28 2022-09-27 Ethicon, Inc. Wound closure systems for reducing surgical site infections comprising incision drapes filled with releasable antimicrobial agents
US11624983B2 (en) 2021-08-31 2023-04-11 Macdermid Graphics Solutions, Llc Method and system for thermal processing of flexo printing elements
CN113521377B (en) * 2021-09-13 2022-04-05 诺一迈尔(山东)医学科技有限公司 Biodegradable tissue adhesives and methods of making the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US55564A (en) * 1866-06-12 Hot-air furnace
US3483870A (en) * 1963-04-22 1969-12-16 Eastman Kodak Co Surgical use of adhesive compositions
US4919939A (en) * 1986-04-29 1990-04-24 Pharmetrix Corporation Periodontal disease treatment system
US5632727A (en) * 1988-10-03 1997-05-27 Atrix Laboratories, Inc. Biodegradable film dressing and method for its formation
BR9508139A (en) * 1994-06-28 1999-11-30 Tri Point Medical Corp Process, process of regulating a biodegradation rate in vivo of a polymer and of joining together two surfaces in vivo, biocompatible composition, adhesive, sealant and surgical implant and delivery system for a therapeutic agent
AU1287895A (en) 1994-10-03 1996-04-26 Otogen Corporation Differentially biodegradable biomedical implants
JPH0912448A (en) * 1995-04-28 1997-01-14 Read Chem Kk Medicine release-control type percutaneous absorptive formulation
US5569223A (en) * 1995-06-06 1996-10-29 Home Access Health Corporation Apparatus and method for enhancing blood flow to obtain a blood sample
US5684042A (en) * 1997-01-10 1997-11-04 Medlogic Global Corporation Cyanoacrylate compositions comprising an antimicrobial agent
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
AU1923199A (en) * 1997-12-17 1999-07-05 Hemodynamics, Inc. Sealing media for surgery and wound closure
US6174919B1 (en) * 1998-02-18 2001-01-16 Closure Medical Corporation Cyanoacrylate compositions with vinyl terminated ester groups
US6207193B1 (en) * 1999-12-27 2001-03-27 Stephen E. Feldman Transdermal drug delivery system

Also Published As

Publication number Publication date
CA2453620A1 (en) 2003-01-30
CA2453620C (en) 2011-09-20
AU2002354960C1 (en) 2003-03-03
EP1803473A2 (en) 2007-07-04
ATE513567T1 (en) 2011-07-15
DE60217121D1 (en) 2007-02-08
EP1409033A1 (en) 2004-04-21
EP1803473B1 (en) 2011-06-22
ES2368439T3 (en) 2011-11-17
ES2279880T3 (en) 2007-09-01
DE60217121T2 (en) 2007-10-25
US20030044380A1 (en) 2003-03-06
WO2003008003A1 (en) 2003-01-30
EP1409033B1 (en) 2006-12-27
FR1409033T (en) 2007-07-20
EP1803473A3 (en) 2008-06-04

Similar Documents

Publication Publication Date Title
ATE513567T1 (en) ADHESIVE CONTAINING MEDICATION
DK1343492T3 (en) Treatment of mucositis
CY1107675T1 (en) TRAMADOLIS MEDICINES
ATE450252T1 (en) MEDICINAL MICROPARTICLES
ATE508725T1 (en) METHOD FOR PRODUCING TABLETS
ES2138584T3 (en) DRUG SUPPLY SYSTEM INVOLVING THE REACTION BETWEEN A PROTEIN OR A POLYPEPTIDE AND A HYDROPHOBIC BIODEGRADABLE POLYMER.
PT1439829E (en) MEDICATION CONTAINING 3- (3-DIMETHYLAMINO-1-ETHYL-2-METHYLPROPYL) -OPHENOL PROVIDING DELAYED RELEASE OF THE ACTIVE SUBSTANCE
BRPI0409652A (en) tablet, pharmaceutical packaging, disease treatment method, and tablet preparation method
SE9402431D0 (en) New tablet formulation
DE60044041D1 (en) Exendine for glucagon suppression
DE122011100049I1 (en) Stable pharmaceutical solution formulations for pressurized inhalers for the administration of metered doses.
CY1115490T1 (en) STRONG CONTAINER CONTAINING A SINGLE CRYSTAL FORM
DE60235083D1 (en) SUBSTITUTED TETRACYCLIN COMPOUNDS FOR THE TREATMENT OF MALARIA
SE0100901D0 (en) New composition
UY27273A1 (en) ORAL ARILPIPRAZOL SOLUTION
BR0309546A (en) A compound, a pharmaceutical composition comprising the same, a process for its preparation and use and a method for the prophylactic or therapeutic treatment of type II diabetes.
DE50211421D1 (en) Device for administering aerosols
DE60335557D1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINED AN OPIOIDANAL GETIC
AR045068A1 (en) FORMULATION OF IMMEDIATE RELEASE OF PHARMACEUTICAL COMPOSITIONS
DE60210552D1 (en) Process for the preparation of a solid pharmaceutical preparation containing a sparingly soluble active substance
ATE442852T1 (en) DELAYED-RELEASE MEDICINAL COMPRISING TRIMETAZIDINE AND METHOD FOR THE PRODUCTION
PT1359903E (en) A PROCESS AND DEVICE FOR THE MANUFACTURE OF FINE PLATELETS FROM AN ACTIVE SUBSTANCE FILM
MA27147A1 (en) SUBSTITUTED 4-PHENYLTETRAHYDRO-ISOQUINOLEINS, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, AND MEDICAMENTS CONTAINING THEM
AR034493A1 (en) COMBINATION OF ACTIVE PRINCIPLES FOR THE MEDICAL TREATMENT OF TOXICOMANS.
NO20004818L (en) Stable dosage forms of fluoxetine and its enantiomers

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties