ATE344249T1 - Pyrazinone, diese verbindungen enthaltende zusammenstellungen - Google Patents
Pyrazinone, diese verbindungen enthaltende zusammenstellungenInfo
- Publication number
- ATE344249T1 ATE344249T1 AT00947711T AT00947711T ATE344249T1 AT E344249 T1 ATE344249 T1 AT E344249T1 AT 00947711 T AT00947711 T AT 00947711T AT 00947711 T AT00947711 T AT 00947711T AT E344249 T1 ATE344249 T1 AT E344249T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- pyrazinones
- compositions containing
- caspase
- hydrates
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 102000003952 Caspase 3 Human genes 0.000 abstract 2
- 108090000397 Caspase 3 Proteins 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14446699P | 1999-07-19 | 1999-07-19 | |
| US17061499P | 1999-12-14 | 1999-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE344249T1 true ATE344249T1 (de) | 2006-11-15 |
Family
ID=26842025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00947711T ATE344249T1 (de) | 1999-07-19 | 2000-07-17 | Pyrazinone, diese verbindungen enthaltende zusammenstellungen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6444811B1 (enExample) |
| EP (1) | EP1202976B1 (enExample) |
| JP (1) | JP4749640B2 (enExample) |
| AT (1) | ATE344249T1 (enExample) |
| AU (1) | AU773317B2 (enExample) |
| CA (1) | CA2378834C (enExample) |
| DE (1) | DE60031686T2 (enExample) |
| ES (1) | ES2274795T3 (enExample) |
| WO (1) | WO2001005772A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1202976B1 (en) * | 1999-07-19 | 2006-11-02 | Merck Frosst Canada Ltd. | Pyrazinones, compositions containing such compounds |
| US20020155172A1 (en) * | 2000-04-07 | 2002-10-24 | Junying Yuan | Methods and compounds for decreasing cell toxicity or death |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| AU2002246065A1 (en) * | 2001-01-26 | 2002-08-06 | Evotec Oai Ag | Methods and means for detecting enzymatic cleavage and linkage reactions |
| FR2827288B1 (fr) * | 2001-07-12 | 2003-10-31 | Servier Lab | Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2003211052A1 (en) | 2002-02-11 | 2003-09-04 | Vertex Pharmaceuticals Incorporated | Phospholipids as caspase inhibitor prodrugs |
| US7960398B2 (en) | 2002-04-19 | 2011-06-14 | Vertex Pharmaceuticals Incorporated | Regulation of TNF-alpha |
| GB2417360B (en) | 2003-05-20 | 2007-03-28 | Kagutech Ltd | Digital backplane |
| HUE024556T2 (hu) | 2004-03-12 | 2016-02-29 | Vertex Pharma | Eljárások és intermedierek aszparagin acetál kapszáz inhibitorok elõállítására |
| CA2567080A1 (en) | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
| US7879891B2 (en) | 2005-07-28 | 2011-02-01 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| KR20080042286A (ko) * | 2006-11-09 | 2008-05-15 | 주식회사 엘지생명과학 | 피리다지논 구조를 포함하는 캐스파제 저해제 |
| WO2009019115A1 (en) | 2007-08-03 | 2009-02-12 | Sanofi-Aventis | Caspase imaging probes |
| WO2009103432A2 (en) * | 2008-02-21 | 2009-08-27 | Sanofi-Aventis | Covalently binding imaging probes |
| US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
| CN109180690A (zh) * | 2018-10-15 | 2019-01-11 | 烟台显华化工科技有限公司 | 一类用作蓝色荧光材料的氮杂芳香化合物及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| WO1999011267A1 (en) | 1997-09-05 | 1999-03-11 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| NZ331993A (en) * | 1996-04-23 | 2000-04-28 | Merck & Co Inc | Pyrazinone thrombin inhibitors |
| EP0934305A4 (en) | 1996-08-29 | 2001-04-11 | Merck & Co Inc | INTEGRINANTAGONISTS |
| US5981546A (en) * | 1996-08-29 | 1999-11-09 | Merck & Co., Inc. | Integrin antagonists |
| JP4199309B2 (ja) * | 1996-09-06 | 2008-12-17 | 日本化薬株式会社 | 新規アセトアミド誘導体およびプロテアーゼ阻害 |
| AU728006B2 (en) | 1997-03-24 | 2001-01-04 | Merck & Co., Inc. | Thrombin inhibitors |
| US5866573A (en) | 1997-04-21 | 1999-02-02 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| EP1202976B1 (en) * | 1999-07-19 | 2006-11-02 | Merck Frosst Canada Ltd. | Pyrazinones, compositions containing such compounds |
-
2000
- 2000-07-17 EP EP00947711A patent/EP1202976B1/en not_active Expired - Lifetime
- 2000-07-17 AT AT00947711T patent/ATE344249T1/de not_active IP Right Cessation
- 2000-07-17 JP JP2001511433A patent/JP4749640B2/ja not_active Expired - Lifetime
- 2000-07-17 ES ES00947711T patent/ES2274795T3/es not_active Expired - Lifetime
- 2000-07-17 AU AU61432/00A patent/AU773317B2/en not_active Expired
- 2000-07-17 CA CA002378834A patent/CA2378834C/en not_active Expired - Lifetime
- 2000-07-17 DE DE60031686T patent/DE60031686T2/de not_active Expired - Lifetime
- 2000-07-17 WO PCT/CA2000/000833 patent/WO2001005772A1/en not_active Ceased
- 2000-07-19 US US09/618,875 patent/US6444811B1/en not_active Expired - Lifetime
-
2002
- 2002-07-25 US US10/202,817 patent/US6699856B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2378834A1 (en) | 2001-01-25 |
| DE60031686T2 (de) | 2007-08-30 |
| AU773317B2 (en) | 2004-05-20 |
| EP1202976A1 (en) | 2002-05-08 |
| AU6143200A (en) | 2001-02-05 |
| EP1202976B1 (en) | 2006-11-02 |
| JP2003505378A (ja) | 2003-02-12 |
| US6444811B1 (en) | 2002-09-03 |
| US20030236402A1 (en) | 2003-12-25 |
| CA2378834C (en) | 2009-07-07 |
| DE60031686D1 (de) | 2006-12-14 |
| WO2001005772A1 (en) | 2001-01-25 |
| JP4749640B2 (ja) | 2011-08-17 |
| US6699856B2 (en) | 2004-03-02 |
| ES2274795T3 (es) | 2007-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE344249T1 (de) | Pyrazinone, diese verbindungen enthaltende zusammenstellungen | |
| JO2282B1 (en) | Oxazole derivatives | |
| MX2007000028A (es) | Derivados de nicotinamida y su uso como agentes terapeuticos. | |
| ECSP066314A (es) | Derivados piridilo y su uso como agentes terapéuticos | |
| AP1860A (en) | Aryl fused azapolycyclic compounds. | |
| GB0413087D0 (en) | Therapeutic compounds | |
| WO2001064639A3 (en) | Pde iv inhibiting amides, compositions and pharmaceutical use | |
| AU2003301020A1 (en) | Isoquinolinone derivatives and their use as therapeutic agents | |
| EA201000643A1 (ru) | Замещенное производное этилендиамина для лечения микобактериальных заболеваний и фармацевтическая композиция на его основе | |
| ATE407928T1 (de) | Amino-phtalazinon derivate, anwendung als kinase inhibitoren, herstellung und pharmazeutische zusammensetzung | |
| WO2004033455A3 (en) | Hemisuccinate salts of heterocyclic dpp-iv inhibitors | |
| WO2005011657A3 (en) | Piperazine derivatives and their use as therapeutic agents | |
| ATE245152T1 (de) | Dioxocyclopentylhydroxamsäure | |
| ATE264852T1 (de) | Chinolinderivate als antibakterielle mittel | |
| MX2007003321A (es) | Derivados heterociclicos y su uso como agentes terapeuticos. | |
| MXPA05014082A (es) | Acidos biariloximetilarenocarboxilicos. | |
| NO20050851L (no) | Kaspase-inhibitorer og anvendelser derav | |
| NO990433L (no) | Nye forbindelser og blandinger for behandling av sykdommer i forbindelse med tryptase-aktivitet | |
| WO2007046868A3 (en) | Thiazolidine derivatives and their uses as therapeutic agents | |
| WO2007046867A3 (en) | Piperidine derivatives and their uses as therapeutic agents | |
| SE9902267D0 (sv) | New compounds | |
| WO2006125194A3 (en) | Piperazine derivatives and their uses as therapeutic agents | |
| DE60107832D1 (en) | Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe | |
| TW200732304A (en) | Piperidine derivatives | |
| DE60119514D1 (de) | Amidderivate der 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentansäure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |