ATE332710T1 - GROWTH INHIBITOR AGAINST LEUKEMIC CELLS CONTAINING ANTISENSE OLIGONUCLEOTIDE DERIVATIVES AGAINST WILMS TUMOR - Google Patents

GROWTH INHIBITOR AGAINST LEUKEMIC CELLS CONTAINING ANTISENSE OLIGONUCLEOTIDE DERIVATIVES AGAINST WILMS TUMOR

Info

Publication number
ATE332710T1
ATE332710T1 AT96914430T AT96914430T ATE332710T1 AT E332710 T1 ATE332710 T1 AT E332710T1 AT 96914430 T AT96914430 T AT 96914430T AT 96914430 T AT96914430 T AT 96914430T AT E332710 T1 ATE332710 T1 AT E332710T1
Authority
AT
Austria
Prior art keywords
antisense oligonucleotide
growth inhibitor
cells containing
oligonucleotide derivatives
leukemic cells
Prior art date
Application number
AT96914430T
Other languages
German (de)
Inventor
Haruo Sugiyama
Tamotsu Yamagami
Kazushi Inoue
Original Assignee
Kishimoto Tadamitsu
Haruo Sugiyama
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kishimoto Tadamitsu, Haruo Sugiyama filed Critical Kishimoto Tadamitsu
Application granted granted Critical
Publication of ATE332710T1 publication Critical patent/ATE332710T1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/311—Phosphotriesters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/313—Phosphorodithioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Abstract

A leukemic cell growth inhibitor containing antisense oligonucleotide derivatives against Wilms' tumor gene (WT1). <IMAGE>
AT96914430T 1995-06-01 1996-05-24 GROWTH INHIBITOR AGAINST LEUKEMIC CELLS CONTAINING ANTISENSE OLIGONUCLEOTIDE DERIVATIVES AGAINST WILMS TUMOR ATE332710T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15667295 1995-06-01

Publications (1)

Publication Number Publication Date
ATE332710T1 true ATE332710T1 (en) 2006-08-15

Family

ID=15632793

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96914430T ATE332710T1 (en) 1995-06-01 1996-05-24 GROWTH INHIBITOR AGAINST LEUKEMIC CELLS CONTAINING ANTISENSE OLIGONUCLEOTIDE DERIVATIVES AGAINST WILMS TUMOR

Country Status (7)

Country Link
US (2) US6034235A (en)
EP (1) EP0841068B1 (en)
AT (1) ATE332710T1 (en)
AU (1) AU5779696A (en)
DE (1) DE69636339T2 (en)
ES (1) ES2268705T3 (en)
WO (1) WO1996038176A1 (en)

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US6977244B2 (en) * 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
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US7285288B1 (en) 1997-10-03 2007-10-23 Board Of Regents, The University Of Texas System Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
CA2337743C (en) * 1998-07-31 2015-07-07 Yoshihiro Oka Tumor antigen based on products of the tumor suppressor gene wt1
US7329410B1 (en) 1998-09-30 2008-02-12 Corixa Corporation Compositions and method for WT1 specific immunotherapy
US20030215458A1 (en) * 1998-09-30 2003-11-20 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20030235557A1 (en) * 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7655249B2 (en) * 1998-09-30 2010-02-02 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7901693B2 (en) * 1998-09-30 2011-03-08 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7115272B1 (en) 1998-09-30 2006-10-03 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7144581B2 (en) * 2000-10-09 2006-12-05 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20030039635A1 (en) * 1998-09-30 2003-02-27 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7063854B1 (en) * 1998-09-30 2006-06-20 Corixa Corporation Composition and methods for WTI specific immunotherapy
WO2002006297A1 (en) * 2000-07-19 2002-01-24 Chugai Seiyaku Kabushiki Kaisha Novel antisense oligonucleotide derivatives against wilms's tumor gene
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US7553494B2 (en) 2001-08-24 2009-06-30 Corixa Corporation WT1 fusion proteins
CA2471967A1 (en) * 2002-01-03 2003-07-31 Board Of Regents, The University Of Texas System Wt1 antisense oligos for the inhibition of breast cancer
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US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
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US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
DE602004023476D1 (en) 2003-01-15 2009-11-19 Chugai Pharmaceutical Co Ltd DIMERIZED PEPTIDE
KR101224235B1 (en) 2003-04-11 2013-01-25 메디뮨 엘엘씨 Recombinant IL-9 Antibodies and Uses Thereof
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WO2005087260A1 (en) * 2004-03-04 2005-09-22 Corixa Corporation Co-encapsulated wt1 polypeptide and immunostimulant microsphere formulations and methods thereof
JP4762133B2 (en) * 2004-03-29 2011-08-31 治夫 杉山 MicroRNA that suppresses expression of WT1 gene and use thereof
EP1741786A4 (en) * 2004-03-29 2007-05-09 Haruo Sugiyama Method of separating precusror cells of liver cells, endothelial cells or hematopoietic cells from cell mass
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Also Published As

Publication number Publication date
US6277832B1 (en) 2001-08-21
DE69636339T2 (en) 2007-07-19
WO1996038176A1 (en) 1996-12-05
DE69636339D1 (en) 2006-08-24
US6034235A (en) 2000-03-07
EP0841068A1 (en) 1998-05-13
EP0841068B1 (en) 2006-07-12
AU5779696A (en) 1996-12-18
ES2268705T3 (en) 2007-03-16
EP0841068A4 (en) 2004-07-07

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