ATE331734T1 - NEUROTROPHIC CILIAR FACTOR WITH ALTERED RANGE OF ACTIVITY COMPARED TO THE WILD-TYPE MOLECULE - Google Patents
NEUROTROPHIC CILIAR FACTOR WITH ALTERED RANGE OF ACTIVITY COMPARED TO THE WILD-TYPE MOLECULEInfo
- Publication number
- ATE331734T1 ATE331734T1 AT97932007T AT97932007T ATE331734T1 AT E331734 T1 ATE331734 T1 AT E331734T1 AT 97932007 T AT97932007 T AT 97932007T AT 97932007 T AT97932007 T AT 97932007T AT E331734 T1 ATE331734 T1 AT E331734T1
- Authority
- AT
- Austria
- Prior art keywords
- factor
- ciliar
- neurotrophic
- wild
- activity compared
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
The variants of human ciliary neutrophic factor (hCNTF) according to the present invention are characterized by substitution of phenylalanine 152 and/or lysine 155 with alanine. These variants have biological properties that render them important as the active principles of drugs for the treatment of diseases and pathologies involving the nervous system or other pathologies involving cells responding to the CNTF. FIG. 2 shows the results of simulation of haptoglobin secretion from HepG2 cells by CNTF and the variants described in the invention.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96RM000492A IT1284867B1 (en) | 1996-07-10 | 1996-07-10 | VARIATIONS OF THE HUMAN CHILIARY NEUROTROPHIC FACTOR (HCNTF) WITH A SPECTRUM OF ACTION DIFFERENT FROM THE WILD-TYPE MOLECULE |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE331734T1 true ATE331734T1 (en) | 2006-07-15 |
Family
ID=11404333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97932007T ATE331734T1 (en) | 1996-07-10 | 1997-07-10 | NEUROTROPHIC CILIAR FACTOR WITH ALTERED RANGE OF ACTIVITY COMPARED TO THE WILD-TYPE MOLECULE |
Country Status (11)
Country | Link |
---|---|
US (1) | US6756357B1 (en) |
EP (1) | EP0936919B1 (en) |
JP (1) | JP3329826B2 (en) |
AT (1) | ATE331734T1 (en) |
AU (1) | AU719086B2 (en) |
CA (1) | CA2260296C (en) |
DE (1) | DE69736241T2 (en) |
ES (1) | ES2265653T3 (en) |
IL (1) | IL127959A0 (en) |
IT (1) | IT1284867B1 (en) |
WO (1) | WO1998001149A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1288388B1 (en) * | 1996-11-19 | 1998-09-22 | Angeletti P Ist Richerche Bio | USE OF SUBSTANCES THAT ACTIVATE THE CNTF RECEPTOR (NEUROTROPHIC CHILI FACTOR) FOR THE PREPARATION OF DRUGS FOR THERAPY |
IT1291114B1 (en) | 1997-03-20 | 1998-12-29 | Angeletti P Ist Richerche Bio | VARIATIONS OF THE CHILIARY NEUROTROPHIC FACTOR (CNTF) WITH IMPROVED RECEPTOR SELECTIVITY, AND METHOD FOR THEIR SELECTION |
EP3551648A4 (en) * | 2016-12-06 | 2020-07-29 | The Board of Trustees of the Leland Stanford Junior University | Ciliary neurotrophic factor receptor ligand-binding agents and methods of using the same |
US11179441B2 (en) | 2017-01-06 | 2021-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Ciliary neurotrophic factor receptor ligands and methods of using the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5349056A (en) | 1992-10-09 | 1994-09-20 | Regeneron Pharmaceuticals | Modified ciliary neurotrophic factors |
WO1995018150A1 (en) * | 1993-12-29 | 1995-07-06 | Sumitomo Pharmaceuticals Company, Limited | Novel human ciliary neurotrophic factor |
GB9413316D0 (en) | 1994-07-01 | 1994-08-24 | Cancer Res Campaign Tech | Novel proteins |
-
1996
- 1996-07-10 IT IT96RM000492A patent/IT1284867B1/en active IP Right Grant
-
1997
- 1997-07-10 AT AT97932007T patent/ATE331734T1/en not_active IP Right Cessation
- 1997-07-10 CA CA002260296A patent/CA2260296C/en not_active Expired - Fee Related
- 1997-07-10 IL IL12795997A patent/IL127959A0/en unknown
- 1997-07-10 DE DE69736241T patent/DE69736241T2/en not_active Expired - Lifetime
- 1997-07-10 US US09/214,718 patent/US6756357B1/en not_active Expired - Fee Related
- 1997-07-10 JP JP50501498A patent/JP3329826B2/en not_active Expired - Fee Related
- 1997-07-10 AU AU35576/97A patent/AU719086B2/en not_active Ceased
- 1997-07-10 EP EP97932007A patent/EP0936919B1/en not_active Expired - Lifetime
- 1997-07-10 WO PCT/IT1997/000163 patent/WO1998001149A2/en active IP Right Grant
- 1997-07-10 ES ES97932007T patent/ES2265653T3/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2000507271A (en) | 2000-06-13 |
IL127959A0 (en) | 1999-11-30 |
CA2260296A1 (en) | 1998-01-15 |
ES2265653T3 (en) | 2007-02-16 |
EP0936919B1 (en) | 2006-06-28 |
EP0936919A2 (en) | 1999-08-25 |
DE69736241T2 (en) | 2007-05-31 |
AU719086B2 (en) | 2000-05-04 |
US6756357B1 (en) | 2004-06-29 |
WO1998001149A3 (en) | 1998-04-23 |
DE69736241D1 (en) | 2006-08-10 |
ITRM960492A0 (en) | 1996-07-10 |
AU3557697A (en) | 1998-02-02 |
IT1284867B1 (en) | 1998-05-22 |
JP3329826B2 (en) | 2002-09-30 |
ITRM960492A1 (en) | 1998-01-10 |
CA2260296C (en) | 2006-05-16 |
WO1998001149A2 (en) | 1998-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |