ATE309254T1 - Gewebespezifische fluoreszierende chelate - Google Patents
Gewebespezifische fluoreszierende chelateInfo
- Publication number
- ATE309254T1 ATE309254T1 AT02773911T AT02773911T ATE309254T1 AT E309254 T1 ATE309254 T1 AT E309254T1 AT 02773911 T AT02773911 T AT 02773911T AT 02773911 T AT02773911 T AT 02773911T AT E309254 T1 ATE309254 T1 AT E309254T1
- Authority
- AT
- Austria
- Prior art keywords
- tissue
- chelates
- specific fluorescent
- fluorescent chelates
- fluorescent
- Prior art date
Links
- 229910052692 Dysprosium Inorganic materials 0.000 abstract 1
- 229910052693 Europium Inorganic materials 0.000 abstract 1
- 208000032383 Soft tissue cancer Diseases 0.000 abstract 1
- 229910052771 Terbium Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- KBQHZAAAGSGFKK-UHFFFAOYSA-N dysprosium atom Chemical compound [Dy] KBQHZAAAGSGFKK-UHFFFAOYSA-N 0.000 abstract 1
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229910052747 lanthanoid Inorganic materials 0.000 abstract 1
- 150000002602 lanthanoids Chemical class 0.000 abstract 1
- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35568401P | 2001-10-22 | 2001-10-22 | |
| PCT/US2002/034242 WO2003035655A1 (en) | 2001-10-22 | 2002-10-22 | Tissue specific fluorescent chelates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309254T1 true ATE309254T1 (de) | 2005-11-15 |
Family
ID=23398394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02773911T ATE309254T1 (de) | 2001-10-22 | 2002-10-22 | Gewebespezifische fluoreszierende chelate |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6962690B2 (de) |
| EP (1) | EP1438318B1 (de) |
| JP (1) | JP2005507005A (de) |
| AT (1) | ATE309254T1 (de) |
| DE (1) | DE60207288T2 (de) |
| WO (1) | WO2003035655A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005049096A2 (en) * | 2003-11-14 | 2005-06-02 | Dow Global Technologies Inc. | Protein and polymer conjugates as chelants with enhanced blood retention |
| DE102004022628A1 (de) | 2004-05-07 | 2005-12-15 | Sensient Imaging Technologies Gmbh | FRET-Bioassay |
| WO2006020779A2 (en) * | 2004-08-10 | 2006-02-23 | Dow Global Technologies Inc. | Targeting chelants and chelates |
| CN101010107A (zh) * | 2004-08-26 | 2007-08-01 | 马林克罗特公司 | 监测肾功能的发光金属络合物 |
| US8193174B2 (en) | 2005-05-11 | 2012-06-05 | University Of Durham | Responsive luminescent lanthanide complexes |
| EP1885817B1 (de) * | 2005-05-11 | 2016-05-11 | University Of Durham | Als sensor geeignete luminiszente lanthanidkomplexe |
| GB0613823D0 (en) | 2006-07-12 | 2006-08-23 | Univ Durham | Assay |
| US7996068B2 (en) * | 2007-03-14 | 2011-08-09 | The Board Of Trustees Of The Leland Stanford Junior University | Surgical method and apparatus for identification of fluorescence |
| US8445217B2 (en) | 2007-09-20 | 2013-05-21 | Vanderbilt University | Free solution measurement of molecular interactions by backscattering interferometry |
| US20100036260A1 (en) | 2008-08-07 | 2010-02-11 | Remicalm Llc | Oral cancer screening device |
| WO2011156713A1 (en) | 2010-06-11 | 2011-12-15 | Vanderbilt University | Multiplexed interferometric detection system and method |
| US9562853B2 (en) | 2011-02-22 | 2017-02-07 | Vanderbilt University | Nonaqueous backscattering interferometric methods |
| US9273949B2 (en) | 2012-05-11 | 2016-03-01 | Vanderbilt University | Backscattering interferometric methods |
| EP3247988A4 (de) | 2015-01-23 | 2018-12-19 | Vanderbilt University | Robustes interferometer und verfahren zur verwendung davon |
| WO2017132483A1 (en) | 2016-01-29 | 2017-08-03 | Vanderbilt University | Free-solution response function interferometry |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8502573D0 (sv) | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
| US4976950A (en) | 1988-12-19 | 1990-12-11 | The Dow Chemical Company | Bone marrow suppressing agents |
| US5312922A (en) | 1992-04-06 | 1994-05-17 | Nordion International Inc. | Europium and terbium chelators for time-resolved fluorometric assays |
| US5714604A (en) | 1993-05-06 | 1998-02-03 | The Dow Chemical Company | Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives |
| US5462725A (en) | 1993-05-06 | 1995-10-31 | The Dow Chemical Company | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| ATE254129T1 (de) | 1996-04-19 | 2003-11-15 | Dow Global Technologies Inc | Fluoreszierende chelate als gewebespezifische bildgebende mittel |
| EP1429783A4 (de) * | 2001-09-04 | 2006-08-09 | Univ Texas Tech | Vielseitig einsetzbare chelate für die multimodale bildeinstellung |
-
2002
- 2002-10-22 EP EP02773911A patent/EP1438318B1/de not_active Expired - Lifetime
- 2002-10-22 WO PCT/US2002/034242 patent/WO2003035655A1/en active IP Right Grant
- 2002-10-22 US US10/278,584 patent/US6962690B2/en not_active Expired - Fee Related
- 2002-10-22 DE DE60207288T patent/DE60207288T2/de not_active Expired - Fee Related
- 2002-10-22 JP JP2003538170A patent/JP2005507005A/ja active Pending
- 2002-10-22 AT AT02773911T patent/ATE309254T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6962690B2 (en) | 2005-11-08 |
| EP1438318B1 (de) | 2005-11-09 |
| DE60207288D1 (de) | 2005-12-15 |
| JP2005507005A (ja) | 2005-03-10 |
| DE60207288T2 (de) | 2006-05-18 |
| US20030099598A1 (en) | 2003-05-29 |
| WO2003035655A1 (en) | 2003-05-01 |
| EP1438318A1 (de) | 2004-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |