ATE309202T1 - N-BIPHENYL METHYL AMINO CYCLO ALKANE CARBOXYLIC ACID AMIDE DERIVATIVES WITH A SUBSTITUENT ON THE METHYL GROUP SUITABLE AS BRADYKININ ANTAGONISTS - Google Patents
N-BIPHENYL METHYL AMINO CYCLO ALKANE CARBOXYLIC ACID AMIDE DERIVATIVES WITH A SUBSTITUENT ON THE METHYL GROUP SUITABLE AS BRADYKININ ANTAGONISTSInfo
- Publication number
- ATE309202T1 ATE309202T1 AT03737624T AT03737624T ATE309202T1 AT E309202 T1 ATE309202 T1 AT E309202T1 AT 03737624 T AT03737624 T AT 03737624T AT 03737624 T AT03737624 T AT 03737624T AT E309202 T1 ATE309202 T1 AT E309202T1
- Authority
- AT
- Austria
- Prior art keywords
- substituent
- carboxylic acid
- acid amide
- amide derivatives
- group suitable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35506202P | 2002-02-08 | 2002-02-08 | |
US41017202P | 2002-09-12 | 2002-09-12 | |
PCT/US2003/003338 WO2003066577A1 (en) | 2002-02-08 | 2003-02-04 | N-biphenylmethyl aminocycloalkanecarboxamide derivatives with a substiituent on the methyl useful as bradykinin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE309202T1 true ATE309202T1 (en) | 2005-11-15 |
Family
ID=27737481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03737624T ATE309202T1 (en) | 2002-02-08 | 2003-02-04 | N-BIPHENYL METHYL AMINO CYCLO ALKANE CARBOXYLIC ACID AMIDE DERIVATIVES WITH A SUBSTITUENT ON THE METHYL GROUP SUITABLE AS BRADYKININ ANTAGONISTS |
Country Status (27)
Country | Link |
---|---|
US (2) | US6919343B2 (en) |
EP (1) | EP1501787B1 (en) |
JP (1) | JP4098249B2 (en) |
KR (1) | KR20040083440A (en) |
CN (1) | CN1328247C (en) |
AR (1) | AR038377A1 (en) |
AT (1) | ATE309202T1 (en) |
AU (1) | AU2003216169B2 (en) |
BR (1) | BR0307508A (en) |
CA (1) | CA2474373C (en) |
DE (1) | DE60302240T2 (en) |
DK (1) | DK1501787T3 (en) |
EA (1) | EA007297B1 (en) |
EC (1) | ECSP045217A (en) |
ES (1) | ES2250899T3 (en) |
HR (1) | HRP20040677A2 (en) |
IS (1) | IS7372A (en) |
JO (1) | JO2356B1 (en) |
MA (1) | MA27108A1 (en) |
MX (1) | MXPA04007660A (en) |
NO (1) | NO20043739L (en) |
NZ (1) | NZ534062A (en) |
PE (1) | PE20030986A1 (en) |
PL (1) | PL371664A1 (en) |
RS (1) | RS65404A (en) |
TW (1) | TWI259079B (en) |
WO (1) | WO2003066577A1 (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
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US7507753B2 (en) * | 2001-12-28 | 2009-03-24 | Takeda Chemical Industries Ltd. | Biaryl compound and use thereof |
ES2256727T3 (en) * | 2002-02-08 | 2006-07-16 | MERCK & CO., INC. | DERIVATIVES OF N-BIFENYLMETIL AMINOCICLOALCANOCARBOXAMIDA. |
CA2495914A1 (en) * | 2002-08-29 | 2004-03-11 | Merck & Co., Inc. | N-biarylmethyl aminocycloalkanecarboxamide derivatives |
US20070093485A1 (en) * | 2002-12-19 | 2007-04-26 | Elan Pharmaceuticals, Inc. | Substituted n-phenyl sulfonamide bradykinin antagonists |
JP2007501790A (en) * | 2003-08-07 | 2007-02-01 | メルク エンド カムパニー インコーポレーテッド | Sulfonyl-substituted N- (biarylmethyl) aminocyclopropanecarboxamide |
WO2005063690A1 (en) * | 2003-12-22 | 2005-07-14 | Merck & Co., Inc. | Alpha-hydroxy amides as bradykinin antagonists or inverse agonists |
CA2557858A1 (en) * | 2004-03-02 | 2005-09-15 | Merck & Co., Inc. | Amino cyclopropane carboxamide derivatives as bradykinin antagonists |
US20050245543A1 (en) * | 2004-04-30 | 2005-11-03 | Pfizer Inc | Histamine-3 receptor antagonists |
CA2575706A1 (en) * | 2004-08-02 | 2006-02-23 | Bebaas, Inc. | Vitamin b12 compositions |
DE102004060542A1 (en) * | 2004-12-16 | 2006-07-06 | Sanofi-Aventis Deutschland Gmbh | Hydroxybiphenyl carboxylic acids and derivatives, process for their preparation and their use |
EP1830869B1 (en) | 2004-12-24 | 2013-05-22 | Spinifex Pharmaceuticals Pty Ltd | Method of treatment or prophylaxis |
US20070178141A1 (en) * | 2005-09-07 | 2007-08-02 | Bebaas, Inc. | Vitamin B12 compositions |
US20130131007A1 (en) | 2005-09-07 | 2013-05-23 | Bebaas, Inc. | Vitamin b12 compositions |
CA2866540A1 (en) * | 2006-03-20 | 2007-09-27 | Spinifex Pharmaceuticals Pty Ltd. | Method of treatment or prophylaxis of inflammatory pain |
US8945505B2 (en) | 2007-02-02 | 2015-02-03 | Panaphix, Inc. | Use of arsenic compounds for treatment of pain and inflammation |
JP4827986B2 (en) | 2007-06-08 | 2011-11-30 | マンカインド コーポレ−ション | IRE-1α inhibitor |
CA2697946C (en) * | 2007-08-29 | 2016-06-28 | Boehringer Ingelheim International Gmbh | Bradykinin b1-antagonists |
US20090270394A1 (en) * | 2008-04-28 | 2009-10-29 | Galemmo Jr Robert | Cyclylamine derivatives as calcium channel blockers |
WO2010097373A1 (en) * | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Compounds for use as bradykinin b1 antagonists |
NZ594674A (en) * | 2009-02-26 | 2013-12-20 | Boehringer Ingelheim Int | Compounds as bradykinin b1 antagonists |
WO2010097374A1 (en) * | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Compounds for use as bradykinin b1 antagonists |
EP2539323B3 (en) * | 2010-02-23 | 2017-10-04 | Boehringer Ingelheim International GmbH | Compounds as bradykinin B1 antagonists |
US10457810B2 (en) | 2009-08-24 | 2019-10-29 | Board Of Trustees Of Michigan State University | Densified biomass products containing pretreated biomass fibers |
BR112012026710B8 (en) | 2010-04-19 | 2020-06-23 | Univ Michigan State | method for producing a product extracted from lignocellulosic biomass and method for producing a product digested from lignocellulosic biomass |
US8937073B2 (en) * | 2010-08-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists |
HUP1000598A2 (en) * | 2010-11-05 | 2012-09-28 | Richter Gedeon Nyrt | Indole derivatives |
US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
US8592426B2 (en) * | 2011-01-24 | 2013-11-26 | Hoffmann—La Roche Inc. | Aryl-benzocycloalkyl amide derivatives |
JP2021501785A (en) * | 2017-11-02 | 2021-01-21 | カリコ ライフ サイエンシーズ エルエルシー | Modulator of integrated stress pathway |
TWI771621B (en) | 2018-10-11 | 2022-07-21 | 美商嘉來克生命科學有限責任公司 | Prodrug modulators of the integrated stress pathway |
Family Cites Families (12)
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US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
IL99372A0 (en) | 1990-09-10 | 1992-08-18 | Ciba Geigy Ag | Azacyclic compounds |
US5208236A (en) * | 1992-09-23 | 1993-05-04 | Schering Corporation | N-(acylaminomethyl)glutaryl amino acids and use |
DK0655461T3 (en) | 1993-11-16 | 2000-10-02 | Novartis Ag | Cyclic amino acid derivatives with ACE and NEP inhibitory activity |
WO1997011717A1 (en) | 1995-09-27 | 1997-04-03 | Novartis Ag | Treatment of chronic progressive renal failure |
US6433185B1 (en) * | 1996-01-11 | 2002-08-13 | Sanofi-Synthelabo | N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them |
FR2743562B1 (en) * | 1996-01-11 | 1998-04-03 | Sanofi Sa | N- (ARYLSULFONYL) AMINO ACID DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
HUP0101640A3 (en) | 1998-04-23 | 2002-10-28 | Novartis Ag | Certain thoil inhibitors of endothelin-converting enzyme |
JP3646062B2 (en) | 1998-04-23 | 2005-05-11 | ノバルティス アクチエンゲゼルシャフト | Heteroaryl-substituted thiol-type inhibitors of endothelin converting enzyme |
US20020052370A1 (en) | 2000-07-06 | 2002-05-02 | Barber Christopher Gordon | Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
DE10036121A1 (en) | 2000-07-25 | 2002-02-07 | Merck Patent Gmbh | N-Substituted-1-amino-1,1-dialkyl-carboxylic acid derivatives |
ES2256727T3 (en) | 2002-02-08 | 2006-07-16 | MERCK & CO., INC. | DERIVATIVES OF N-BIFENYLMETIL AMINOCICLOALCANOCARBOXAMIDA. |
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2003
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- 2003-02-04 PE PE2003000132A patent/PE20030986A1/en not_active Application Discontinuation
- 2003-02-04 AT AT03737624T patent/ATE309202T1/en not_active IP Right Cessation
- 2003-02-04 CA CA002474373A patent/CA2474373C/en not_active Expired - Fee Related
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- 2003-02-04 AU AU2003216169A patent/AU2003216169B2/en not_active Ceased
- 2003-02-04 CN CNB03803560XA patent/CN1328247C/en not_active Expired - Fee Related
- 2003-02-04 US US10/503,501 patent/US20050084463A1/en not_active Abandoned
- 2003-02-04 BR BR0307508-7A patent/BR0307508A/en not_active IP Right Cessation
- 2003-02-04 DK DK03737624T patent/DK1501787T3/en active
- 2003-02-04 RS YUP-654/04A patent/RS65404A/en unknown
- 2003-02-04 JP JP2003565952A patent/JP4098249B2/en not_active Expired - Fee Related
- 2003-02-04 EA EA200401054A patent/EA007297B1/en not_active IP Right Cessation
- 2003-02-04 DE DE60302240T patent/DE60302240T2/en not_active Expired - Lifetime
- 2003-02-04 KR KR10-2004-7012238A patent/KR20040083440A/en not_active Application Discontinuation
- 2003-02-04 EP EP03737624A patent/EP1501787B1/en not_active Expired - Lifetime
- 2003-02-04 PL PL03371664A patent/PL371664A1/en unknown
- 2003-02-04 ES ES03737624T patent/ES2250899T3/en not_active Expired - Lifetime
- 2003-02-06 JO JO200315A patent/JO2356B1/en active
-
2004
- 2004-07-23 HR HR20040677A patent/HRP20040677A2/en not_active Application Discontinuation
- 2004-07-26 IS IS7372A patent/IS7372A/en unknown
- 2004-08-02 EC EC2004005217A patent/ECSP045217A/en unknown
- 2004-08-10 MA MA27820A patent/MA27108A1/en unknown
- 2004-09-07 NO NO20043739A patent/NO20043739L/en not_active Application Discontinuation
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