ATE300548T1 - Herstellung von thiophosphonoformatestern - Google Patents
Herstellung von thiophosphonoformatesternInfo
- Publication number
- ATE300548T1 ATE300548T1 AT00930305T AT00930305T ATE300548T1 AT E300548 T1 ATE300548 T1 AT E300548T1 AT 00930305 T AT00930305 T AT 00930305T AT 00930305 T AT00930305 T AT 00930305T AT E300548 T1 ATE300548 T1 AT E300548T1
- Authority
- AT
- Austria
- Prior art keywords
- esters
- thiophosphonoformate
- thiophosphite
- phosphite
- production
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 2
- -1 phosphite diesters Chemical class 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- OSIAURSWRZARKZ-UHFFFAOYSA-N dihydroxyphosphinothioylformic acid Chemical class OC(=O)P(O)(O)=S OSIAURSWRZARKZ-UHFFFAOYSA-N 0.000 abstract 1
- LVFUWJLIDMSANU-UHFFFAOYSA-N methoxy(methylsulfanyl)phosphinous acid Chemical compound COP(O)SC LVFUWJLIDMSANU-UHFFFAOYSA-N 0.000 abstract 1
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical class OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 238000007280 thionation reaction Methods 0.000 abstract 1
- 150000005691 triesters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
- C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/201—Esters of thiophosphorus acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/304,252 US6147244A (en) | 1999-05-03 | 1999-05-03 | Preparations of thiophosphites and thiophosphonates |
| PCT/US2000/011940 WO2000066598A1 (en) | 1999-05-03 | 2000-05-03 | Improved preparations of thiophosphites and thiophosphonates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE300548T1 true ATE300548T1 (de) | 2005-08-15 |
Family
ID=23175720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00930305T ATE300548T1 (de) | 1999-05-03 | 2000-05-03 | Herstellung von thiophosphonoformatestern |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6147244A (de) |
| EP (1) | EP1095047B1 (de) |
| AT (1) | ATE300548T1 (de) |
| AU (1) | AU4815100A (de) |
| CA (1) | CA2336605A1 (de) |
| DE (1) | DE60021500T2 (de) |
| ES (1) | ES2244442T3 (de) |
| WO (1) | WO2000066598A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9050310B2 (en) * | 2004-06-25 | 2015-06-09 | Minas Theodore Coroneo | Treatment of ocular lesions |
| US20060204474A1 (en) * | 2005-02-25 | 2006-09-14 | Coroneo Minas T | Treatment of epithelial layer lesions |
| WO2006096859A2 (en) * | 2005-03-07 | 2006-09-14 | Adventrx Pharmaceuticals, Inc. | THE USE OF THIOPHOSPHONOFORMIC ACID AND NRTIs TO TREAT VIRAL INFECTIONS |
| US11045441B2 (en) | 2015-10-13 | 2021-06-29 | Wisconsin Alumni Research Foundation | Use of retinoic acid and analogs thereof to treat central neural apneas |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4466895A (en) * | 1983-06-27 | 1984-08-21 | The Lubrizol Corporation | Metal salts of lower dialkylphosphorodithioic acids |
| DD219198A1 (de) * | 1983-11-02 | 1985-02-27 | Kurt Issleib | Verfahren zur herstellung von phosphonoformiaten |
| US5183812A (en) * | 1989-06-21 | 1993-02-02 | Mckenna Charles E | Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid |
| US5072032A (en) * | 1989-06-21 | 1991-12-10 | Mckenna Charles E | Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid |
-
1999
- 1999-05-03 US US09/304,252 patent/US6147244A/en not_active Expired - Fee Related
-
2000
- 2000-05-03 EP EP00930305A patent/EP1095047B1/de not_active Expired - Lifetime
- 2000-05-03 AT AT00930305T patent/ATE300548T1/de not_active IP Right Cessation
- 2000-05-03 CA CA002336605A patent/CA2336605A1/en not_active Abandoned
- 2000-05-03 DE DE60021500T patent/DE60021500T2/de not_active Expired - Fee Related
- 2000-05-03 WO PCT/US2000/011940 patent/WO2000066598A1/en not_active Ceased
- 2000-05-03 ES ES00930305T patent/ES2244442T3/es not_active Expired - Lifetime
- 2000-05-03 AU AU48151/00A patent/AU4815100A/en not_active Abandoned
- 2000-11-01 US US09/703,564 patent/US6284909B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6284909B1 (en) | 2001-09-04 |
| CA2336605A1 (en) | 2000-11-09 |
| AU4815100A (en) | 2000-11-17 |
| WO2000066598A1 (en) | 2000-11-09 |
| DE60021500T2 (de) | 2006-05-24 |
| EP1095047B1 (de) | 2005-07-27 |
| EP1095047A4 (de) | 2002-05-15 |
| EP1095047A1 (de) | 2001-05-02 |
| ES2244442T3 (es) | 2005-12-16 |
| DE60021500D1 (de) | 2005-09-01 |
| US6147244A (en) | 2000-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1095047 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |