ATE295838T1 - BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH MICROGLIA ACTIVATION, SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES - Google Patents

BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH MICROGLIA ACTIVATION, SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES

Info

Publication number
ATE295838T1
ATE295838T1 AT02740766T AT02740766T ATE295838T1 AT E295838 T1 ATE295838 T1 AT E295838T1 AT 02740766 T AT02740766 T AT 02740766T AT 02740766 T AT02740766 T AT 02740766T AT E295838 T1 ATE295838 T1 AT E295838T1
Authority
AT
Austria
Prior art keywords
treatment
allergic
infectious
inflammatory
benzimidazole derivatives
Prior art date
Application number
AT02740766T
Other languages
German (de)
Inventor
Thorsten Blume
Wolfgang Halfbrodt
Joachim Kuhnke
Ursula Moenning
Herbert Schneider
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE295838T1 publication Critical patent/ATE295838T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Abstract

The invention relates to novel benzimidazole derivatives with general formula (I), whereby the radicals R<1>, R<2>, R<3>, A, B, Y and Z have the meanings as cited in the description and in the claims. The invention also relates to the use of these compounds for producing a medicament used for the treatment and prophylaxis of diseases associated with a microglia-activation, and to pharmaceutical preparations containing these compounds.
AT02740766T 2001-07-09 2002-07-05 BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH MICROGLIA ACTIVATION, SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES ATE295838T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10135050A DE10135050A1 (en) 2001-07-09 2001-07-09 1-Ary1-2-N-, S- or O-substituted benzimidazole derivatives, their use for the preparation of medicaments and pharmaceutical preparations containing them
PCT/EP2002/007561 WO2003006438A1 (en) 2001-07-09 2002-07-05 Benzimidazole derivatives for treating microglia-activation associated diseases such as inflammatory, allergic, infectious or autoimmune diseases

Publications (1)

Publication Number Publication Date
ATE295838T1 true ATE295838T1 (en) 2005-06-15

Family

ID=7692286

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02740766T ATE295838T1 (en) 2001-07-09 2002-07-05 BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH MICROGLIA ACTIVATION, SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES

Country Status (10)

Country Link
EP (1) EP1404656B9 (en)
JP (1) JP4351042B2 (en)
AT (1) ATE295838T1 (en)
DE (2) DE10135050A1 (en)
DK (1) DK1404656T3 (en)
ES (1) ES2242866T3 (en)
PE (1) PE20030236A1 (en)
PT (1) PT1404656E (en)
UY (1) UY27372A1 (en)
WO (1) WO2003006438A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10207843A1 (en) * 2002-02-15 2003-09-04 Schering Ag Microlia inhibitors for interruption of interleukin 12 and IFN-gamma mediated immune responses
EP1529046A1 (en) 2002-08-08 2005-05-11 Boehringer Ingelheim Pharmaceuticals Inc. Substituted benzimidazole compounds
JP2006505570A (en) 2002-10-17 2006-02-16 アムジエン・インコーポレーテツド Benzimidazole derivatives and their use as vanilloid receptor ligands
JPWO2006038738A1 (en) * 2004-10-08 2008-05-15 武田薬品工業株式会社 Receptor function regulator
EP2319512A1 (en) 2005-01-11 2011-05-11 NeuroSearch AS Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels.
CN103435552A (en) * 2013-06-28 2013-12-11 浙江工业大学 1,2-disubstituted benzimidazole compound preparation method
KR20210125471A (en) 2018-10-05 2021-10-18 안나푸르나 바이오, 인코포레이티드 Compounds and Compositions for Treating Conditions Associated with APJ Receptor Activity

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8300736D0 (en) * 1983-02-11 1983-02-11 Haessle Ab NOVEL PHARMACOLOGICALLY ACTIVE COMPOUNDS
US4520196A (en) * 1983-08-18 1985-05-28 American Home Products Corporation α-Mercaptophenylacetic acid derivatives of imidazole-containing compounds and analogues thereof
EP0251536A1 (en) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
JPH06759B2 (en) * 1989-09-22 1994-01-05 ファイザー製薬株式会社 Novel benzimidazole compound
US5210091A (en) * 1991-06-24 1993-05-11 Neurosearch A/S Imidazole compounds and their use
EP0520200B1 (en) * 1991-06-24 1998-02-18 Neurosearch A/S Imidazole compounds, their preparation and use
DE4129603A1 (en) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K CONDENSED 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THESE COMPOUNDS
DK154092D0 (en) * 1992-12-23 1992-12-23 Neurosearch As IMIDAZOLE COMPOUNDS, THEIR PREPARATION AND USE
DE4330959A1 (en) * 1993-09-09 1995-03-16 Schering Ag New benzimidazole derivatives, processes for their preparation and their pharmaceutical use
US5552426A (en) * 1994-04-29 1996-09-03 Eli Lilly And Company Methods for treating a physiological disorder associated with β-amyloid peptide
GB9518552D0 (en) * 1995-09-11 1995-11-08 Fujisawa Pharmaceutical Co New heterocyclic compounds
DE19816915A1 (en) * 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma New dipeptide derivatives useful as neuropeptide Y agonists and/or antagonists for treating cardiovascular disorders, coronary, cerebral or renal vasospasms, obesity, bulimia and asthma
JP2000026430A (en) * 1998-07-02 2000-01-25 Taisho Pharmaceut Co Ltd 2,5,6-substituted benzimidazole compound derivative
DE19900355A1 (en) * 1999-01-07 2000-07-13 Merck Patent Gmbh New 2-(naphthalen-2-ylmethyl)-benzimidazole derivatives are Factor VIIa, IXa, Xa and thrombin inhibitors useful for treating thrombosis and other cardiovascular disorders, inflammation and apoplexy
EP1165518A2 (en) * 1999-04-02 2002-01-02 Neurogen Corporation Benzimidazole and imidazolopyridine derivatives, their preparation and their use as selective modulators of bradykinin b2 (= bk-2) receptors
CA2383546A1 (en) * 1999-06-30 2001-01-04 William H. Parsons Src kinase inhibitor compounds
RU2223761C2 (en) * 1999-12-27 2004-02-20 Джапан Тобакко Инк. Ring-condensed compounds and their using as medicinal agents
JP2003523961A (en) * 2000-01-14 2003-08-12 シエーリング アクチエンゲゼルシャフト 1,2-Diarylbenzimidazoles for the treatment of diseases associated with microglial activation

Also Published As

Publication number Publication date
UY27372A1 (en) 2003-01-31
WO2003006438A1 (en) 2003-01-23
DE50203154D1 (en) 2005-06-23
EP1404656A1 (en) 2004-04-07
DE10135050A1 (en) 2003-02-06
PT1404656E (en) 2005-09-30
DK1404656T3 (en) 2005-09-12
JP2004536123A (en) 2004-12-02
JP4351042B2 (en) 2009-10-28
EP1404656B1 (en) 2005-05-18
ES2242866T3 (en) 2005-11-16
PE20030236A1 (en) 2003-04-10
EP1404656B9 (en) 2005-10-19

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