ATE283487T1 - METHOD FOR DIAGNOSIS OR PROGNOSIS OF AGE-RELATED MACULAR DEGENERATION - Google Patents
METHOD FOR DIAGNOSIS OR PROGNOSIS OF AGE-RELATED MACULAR DEGENERATIONInfo
- Publication number
- ATE283487T1 ATE283487T1 AT00967639T AT00967639T ATE283487T1 AT E283487 T1 ATE283487 T1 AT E283487T1 AT 00967639 T AT00967639 T AT 00967639T AT 00967639 T AT00967639 T AT 00967639T AT E283487 T1 ATE283487 T1 AT E283487T1
- Authority
- AT
- Austria
- Prior art keywords
- age
- macular degeneration
- related macular
- subject
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Abstract
A method for diagnosing or prognosticating age-related macular degeneration in a subject, or determining whether a subject is at increased risk of developing age-related macular degeneration or monitoring the progression of age-related macular degeneration in a subject, comprising: determining a level, or an activity, or both said level and said activity, of at least one substance which is selected from the group consisting of a transcription product of a Cystatin C gene, a translation product of a Cystatin C gene, a fragment of said translation product, an amyloid protein, and a transcription product of a gene coding for an amyloid protein in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of at least one of said substances to a reference value representing a known disease or health status, thereby diagnosing or prognosticating said age-related macular degeneration in said subject, or determining whether said subject is at increased risk of developing age-related macular degeneration or monitoring the progression of said age-related macular degeneration in said subject.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99117198 | 1999-09-01 | ||
EP00101921 | 2000-02-01 | ||
PCT/EP2000/008554 WO2001016364A2 (en) | 1999-09-01 | 2000-09-01 | Methods of diagnosing or prognosticating age-related macular degeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE283487T1 true ATE283487T1 (en) | 2004-12-15 |
Family
ID=26070484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00967639T ATE283487T1 (en) | 1999-09-01 | 2000-09-01 | METHOD FOR DIAGNOSIS OR PROGNOSIS OF AGE-RELATED MACULAR DEGENERATION |
Country Status (5)
Country | Link |
---|---|
US (1) | US20070117122A1 (en) |
EP (1) | EP1210464B1 (en) |
AT (1) | ATE283487T1 (en) |
DE (1) | DE60016242T2 (en) |
WO (1) | WO2001016364A2 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10303974A1 (en) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid β (1-42) oligomers, process for their preparation and their use |
EP1861511A4 (en) * | 2005-03-04 | 2010-01-20 | Univ Duke | Genetic variants increase the risk of age-related macular degeneration |
KR101354876B1 (en) * | 2005-06-08 | 2014-02-18 | 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | SUSCEPTIBILITY GENES FOR AGE-RELATED MACULOPATHY(ARM) ON CHROMOSOME 10q26 |
CA2627686A1 (en) * | 2005-11-02 | 2007-05-18 | The Government Of The United States Of America, As Represented By The Se Cretary Of Health And Human Services | Method evolved for recognition and testing of age related macular degeneration (mert-armd) |
DK1954718T3 (en) | 2005-11-30 | 2014-12-15 | Abbvie Inc | Anti-A-globulomer antibodies antigenbindingsgrupper thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods for producing said antibodies, |
EP1976877B2 (en) | 2005-11-30 | 2016-10-05 | AbbVie Inc. | Monoclonal antibodies against amyloid beta protein and uses thereof |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
EP2486928A1 (en) | 2007-02-27 | 2012-08-15 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
WO2008110283A2 (en) * | 2007-03-14 | 2008-09-18 | Dsm Ip Assets B.V. | Method for prevention of age-related macular degeneration (amd) |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
CA2701793C (en) | 2007-10-05 | 2017-04-25 | Genentech, Inc. | Use of anti-amyloid beta antibody in ocular diseases |
EP2205631B1 (en) * | 2007-10-05 | 2016-11-23 | Genentech, Inc. | Methods and compositions for diagnosis and treatment of amyloidosis |
CA2796339C (en) | 2010-04-15 | 2020-03-31 | Abbott Laboratories | Amyloid-beta binding proteins |
CN103179981B (en) | 2010-07-30 | 2017-02-08 | Ac免疫有限公司 | Safe and functional humanized antibodies |
US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
EP2497490A1 (en) * | 2011-03-07 | 2012-09-12 | Bioquanta | Methods for diagnosing and/or treating sterility |
JP5721150B2 (en) * | 2013-03-14 | 2015-05-20 | 学校法人 埼玉医科大学 | Prediction risk of age-related macular degeneration |
EP4311574A1 (en) * | 2022-07-29 | 2024-01-31 | Chung-Ang University Industry-Academic Cooperation | Prevention and treatment of age-related macular degeneration through suppression of cathepsin s expression |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3724581A1 (en) * | 1987-07-24 | 1989-02-02 | Gruenenthal Gmbh | DNA SEQUENCES COATING FOR PROTEINS WITH THE BIOLOGICAL PROPERTIES OF CYSTATINE C, PREPARATION OF THESE DNA SEQUENCES, EXPRESSION OF CYSTATINE C, AND PHARMACEUTICAL PREPARATIONS CONTAINING THEREOF |
US5231000A (en) * | 1987-10-08 | 1993-07-27 | The Mclean Hospital | Antibodies to A4 amyloid peptide |
US5262332A (en) * | 1989-04-05 | 1993-11-16 | Brigham And Women's Hospital | Diagnostic method for Alzheimer's disease: examination of non-neural tissue |
EP0527823A1 (en) * | 1990-04-24 | 1993-02-24 | The Regents Of The University Of California | Purification, detection and methods of use of protease nexin-2 |
US5981471A (en) * | 1997-02-06 | 1999-11-09 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
-
2000
- 2000-09-01 AT AT00967639T patent/ATE283487T1/en not_active IP Right Cessation
- 2000-09-01 EP EP00967639A patent/EP1210464B1/en not_active Expired - Lifetime
- 2000-09-01 WO PCT/EP2000/008554 patent/WO2001016364A2/en active IP Right Grant
- 2000-09-01 DE DE60016242T patent/DE60016242T2/en not_active Expired - Fee Related
-
2006
- 2006-09-25 US US11/526,188 patent/US20070117122A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1210464B1 (en) | 2004-11-24 |
WO2001016364A3 (en) | 2002-03-14 |
DE60016242D1 (en) | 2004-12-30 |
WO2001016364A2 (en) | 2001-03-08 |
US20070117122A1 (en) | 2007-05-24 |
DE60016242T2 (en) | 2005-12-01 |
EP1210464A2 (en) | 2002-06-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE283487T1 (en) | METHOD FOR DIAGNOSIS OR PROGNOSIS OF AGE-RELATED MACULAR DEGENERATION | |
DE60233485D1 (en) | METHOD FOR DIAGNOSIS, TREATMENT AND PREVENTION OF BONE LOSS | |
Crist et al. | Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease | |
ATE312946T1 (en) | METHOD AND DEVICE FOR DETERMINING THE TISSUE SPECIFICITY OF FREE DNA IN BODY FLUID | |
DE60239470D1 (en) | METHOD FOR EVALUATING PATHOLOGICAL ILLICIT STATES USING EXTRACELLULAR RNA | |
ATE419390T1 (en) | METHOD FOR DIAGNOSIS OF PANCREATIC CANCER | |
NO20050186D0 (en) | Oligosaccharide Biomarkers for Mucopolysaccharides and Other Related Disorders | |
RU2008103988A (en) | METHOD FOR DIAGNOSIS OF MULTIPLE SCLEROSIS | |
ATE514948T1 (en) | IN VITRO METHOD FOR DIAGNOSING NEURODEGENERATIVE DISEASES | |
ATE474227T1 (en) | DETERMINATION OF FELINE AND CANINE PROBNP | |
WO2017106363A1 (en) | Refining diagnosis and treatment of complex multi-symptom neurological disorders | |
WO2007015113A3 (en) | New protein isoforms of the pif-family and uses thereof | |
Klee et al. | Analytic bias specifications based on the analysis of effects on performance of medical guidelines | |
ATE286253T1 (en) | METHODS FOR DIAGNOSIS OR PROGNOSIS OF ALZHEIMER'S DISEASE | |
ATE494556T1 (en) | METHOD FOR DIAGNOSING INFLAMMATORY DISEASES AND INFECTIONS USING LASP-1/LAP-1 DETERMINATION | |
DE60038614D1 (en) | METHOD FOR THE DIAGNOSIS OF SYNOVIAL OR OSTEOARTICULAR DISEASES | |
ATE225405T1 (en) | METHOD FOR DIAGNOSIS OR PROGNOSIS OF ALZHEIMER'S DISEASE: THERAPEUTIC COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE | |
DE60033646D1 (en) | METHODS FOR DIAGNOSIS OR TREATMENT OF ALZHEIMER DISEASE | |
ATE343793T1 (en) | METHOD FOR DIAGNOSIS, PROGNOSIS OR EVALUATION OF TREATMENT OF DEPRESSION BASED ON INCREASED NEUROTROPHIN CONCENTRATIONS IN CEREBROSPINAL FLUID. | |
DE502004012230D1 (en) | METHOD FOR THE DIAGNOSIS OF ILLNESSES DETERMINED BY APOLIPOPROTEIN C-I | |
ATE485515T1 (en) | METHOD FOR DIAGNOSIS OF A PERSON WITH MULTIPLE SCLERosis | |
ATE312914T1 (en) | RDGB PROTEINS | |
Delacourte et al. | The Biochemical Spreading of Tau and Amyloid-Precursor Protein Pathologies in Aging and Sporadic Alzheimer’s Disease | |
DE602005023973D1 (en) | METHOD FOR THE DIAGNOSIS OF CHRONIC STRESS AND RELATED DISEASES | |
ATE442456T1 (en) | METHOD FOR DETERMINING CIRCULATIVE DNA IN PLASMA AND DETECTING CANCER |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1210464 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |