ATE27T1 - LACTAM-N-ACETIC ACIDS AND THEIR AMIDES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM - Google Patents
LACTAM-N-ACETIC ACIDS AND THEIR AMIDES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEMInfo
- Publication number
- ATE27T1 ATE27T1 AT79870012T AT79870012T ATE27T1 AT E27 T1 ATE27 T1 AT E27T1 AT 79870012 T AT79870012 T AT 79870012T AT 79870012 T AT79870012 T AT 79870012T AT E27 T1 ATE27 T1 AT E27T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyleneimino
- amides
- lactam
- acetic acids
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D227/00—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00
- C07D227/02—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D227/06—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D227/08—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Polyamides (AREA)
Abstract
New lactam-N-acetic acids and amides thereof having the formula <IMAGE> wherein R1 and R2=H, C1-C4-alkyl, aryl or halogen-substituted aryl, R3=OH or -NR4R5, R4 and R5=H, C1-C4-alkyl, cycloalkyl, aralkyl or, taken together with the N atom form alkyleneimino, oxa-alkyleneimino, aza-alkyleneimino or N-benzyl-aza-alkyleneimino, m is 3, 4 or 5, preferably 3, n is 0, 1 or 2, preferably 2; and the pharmaceutically acceptable salts of said acids. Processes for producing these compounds and pharmaceutical compositions containing the same are also given. These compounds show amongst others beneficial activity on the mnemic processes and cardiac activity.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1816078 | 1978-05-08 | ||
EP79870012A EP0005689B1 (en) | 1978-05-08 | 1979-05-02 | Lactam-n-acetic acids, their amides, process for their preparation and therapeutic compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE27T1 true ATE27T1 (en) | 1981-04-15 |
Family
ID=10107678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT79870012T ATE27T1 (en) | 1978-05-08 | 1979-05-02 | LACTAM-N-ACETIC ACIDS AND THEIR AMIDES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM |
Country Status (23)
Country | Link |
---|---|
US (1) | US4221789A (en) |
EP (1) | EP0005689B1 (en) |
JP (1) | JPS54154760A (en) |
AT (1) | ATE27T1 (en) |
AU (1) | AU522815B2 (en) |
BE (1) | BE876067A (en) |
CA (1) | CA1119593A (en) |
DE (2) | DE2960194D1 (en) |
DK (1) | DK150064C (en) |
ES (1) | ES480299A1 (en) |
FI (1) | FI66602C (en) |
FR (1) | FR2425433A1 (en) |
GR (1) | GR67631B (en) |
HU (1) | HU178362B (en) |
IT (1) | IT7948950A0 (en) |
NL (1) | NL7903536A (en) |
NO (1) | NO150639C (en) |
PL (1) | PL117056B1 (en) |
PT (1) | PT69582A (en) |
SE (1) | SE7903864L (en) |
SU (2) | SU1093245A3 (en) |
YU (1) | YU41340B (en) |
ZA (1) | ZA792175B (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2944456C2 (en) * | 1979-11-03 | 1982-04-01 | Hoechst Ag, 6000 Frankfurt | Process for the preparation of N-? -Alkoxyalkyl-carboxamides |
US4396616A (en) * | 1981-09-04 | 1983-08-02 | Merck & Co., Inc. | Substituted enantholactam derivatives as antihypertensives |
DE3361609D1 (en) * | 1982-03-24 | 1986-02-06 | Prodes Sa | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts |
US4608201A (en) * | 1984-05-21 | 1986-08-26 | Ppg Industries, Inc. | Process for preparing lactam imides |
CA1322199C (en) * | 1987-07-15 | 1993-09-14 | Masami Eigyo | N-¬(2-oxopyrrolidin-1-yl) acetyl)| piperazine derivatives and drug for senile dementia |
IT1242043B (en) * | 1990-12-21 | 1994-02-02 | Sigma Tau Ind Farmaceuti | DERIVATIVES OF 1,2,3,4, -TETRAIDRONAFTILAMINA WITH NOOTROPIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
IT1245870B (en) * | 1991-06-05 | 1994-10-25 | Sigma Tau Ind Farmaceuti | 3-ACYLAMIN-2-PYROLIDINONE AS ACTIVATORS OF LEARNING PROCESSES AND MEMORY AND PHARMACEUTICAL COMPOSITIONS INCLUDING SUCH COMPOUNDS |
US5510477A (en) * | 1994-03-01 | 1996-04-23 | The Procter & Gamble Company | Process for the acylation of lactams |
AU1369001A (en) * | 1995-12-13 | 2001-03-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5914332A (en) * | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US7834043B2 (en) * | 2003-12-11 | 2010-11-16 | Abbott Laboratories | HIV protease inhibiting compounds |
AU2009303834B2 (en) * | 2008-10-16 | 2016-08-11 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
CN109662964A (en) * | 2010-02-09 | 2019-04-23 | 约翰斯.霍普金斯大学 | For improving the method and composition of cognitive function |
JP6440625B2 (en) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | Methods and compositions for treating schizophrenia |
EP3827820A1 (en) | 2013-03-15 | 2021-06-02 | The Johns Hopkins University | Brivaracetam for improving cognitive function |
WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
BR112017025031B1 (en) | 2015-05-22 | 2023-03-21 | Agenebio, Inc | LEVETIRACETAM EXTENDED RELEASE PHARMACEUTICAL COMPOSITIONS |
EP3331872B1 (en) | 2015-08-05 | 2019-09-25 | Bristol-Myers Squibb Company | Novel substituted glycine derived fxia inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2657215A (en) * | 1950-03-10 | 1953-10-27 | Goodrich Co B F | Method for the preparation of novel n-(2-carboxyalkyl) succinimides |
DE1081896B (en) * | 1959-03-28 | 1960-05-19 | Bayer Ag | Process for the preparation of ª-amino-ª-hydroxycarboxylic acids |
GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
GB1039113A (en) | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
US3751262A (en) * | 1970-06-30 | 1973-08-07 | Allied Chem | Ruminant feed supplement |
GB1539817A (en) * | 1976-10-22 | 1979-02-07 | Ucb Sa | N-substituted lactams |
-
1979
- 1979-05-02 AT AT79870012T patent/ATE27T1/en not_active IP Right Cessation
- 1979-05-02 EP EP79870012A patent/EP0005689B1/en not_active Expired
- 1979-05-02 DE DE7979870012T patent/DE2960194D1/en not_active Expired
- 1979-05-03 FI FI791421A patent/FI66602C/en not_active IP Right Cessation
- 1979-05-03 DK DK182379A patent/DK150064C/en not_active IP Right Cessation
- 1979-05-03 NO NO791477A patent/NO150639C/en unknown
- 1979-05-03 SE SE7903864A patent/SE7903864L/en unknown
- 1979-05-04 NL NL7903536A patent/NL7903536A/en not_active Application Discontinuation
- 1979-05-07 CA CA000325925A patent/CA1119593A/en not_active Expired
- 1979-05-07 ZA ZA792175A patent/ZA792175B/en unknown
- 1979-05-07 PL PL1979215420A patent/PL117056B1/en unknown
- 1979-05-07 ES ES480299A patent/ES480299A1/en not_active Expired
- 1979-05-07 PT PT69582A patent/PT69582A/en unknown
- 1979-05-07 GR GR59038A patent/GR67631B/el unknown
- 1979-05-07 AU AU46816/79A patent/AU522815B2/en not_active Expired
- 1979-05-07 IT IT7948950A patent/IT7948950A0/en unknown
- 1979-05-07 FR FR7911537A patent/FR2425433A1/en not_active Withdrawn
- 1979-05-07 BE BE1/9378A patent/BE876067A/en unknown
- 1979-05-07 US US06/036,987 patent/US4221789A/en not_active Expired - Lifetime
- 1979-05-08 SU SU792763201A patent/SU1093245A3/en active
- 1979-05-08 JP JP5622979A patent/JPS54154760A/en active Granted
- 1979-05-08 YU YU1069/79A patent/YU41340B/en unknown
- 1979-05-08 HU HU79UE94A patent/HU178362B/en not_active IP Right Cessation
- 1979-05-08 DE DE19792918523 patent/DE2918523A1/en not_active Withdrawn
- 1979-11-26 SU SU792847114A patent/SU969701A1/en active
Also Published As
Publication number | Publication date |
---|---|
PT69582A (en) | 1979-06-01 |
YU106979A (en) | 1983-04-30 |
CA1119593A (en) | 1982-03-09 |
ES480299A1 (en) | 1980-08-16 |
IT7948950A0 (en) | 1979-05-07 |
AU522815B2 (en) | 1982-06-24 |
NL7903536A (en) | 1979-11-12 |
US4221789A (en) | 1980-09-09 |
PL117056B1 (en) | 1981-07-31 |
DE2960194D1 (en) | 1981-04-16 |
FI66602B (en) | 1984-07-31 |
YU41340B (en) | 1987-02-28 |
FI791421A (en) | 1979-11-09 |
FR2425433A1 (en) | 1979-12-07 |
HU178362B (en) | 1982-04-28 |
BE876067A (en) | 1979-11-07 |
DE2918523A1 (en) | 1979-11-15 |
DK150064C (en) | 1987-06-15 |
FI66602C (en) | 1984-11-12 |
NO150639C (en) | 1984-11-21 |
AU4681679A (en) | 1979-11-15 |
JPS6220982B2 (en) | 1987-05-11 |
SE7903864L (en) | 1979-11-09 |
ZA792175B (en) | 1980-05-28 |
SU969701A1 (en) | 1982-10-30 |
EP0005689B1 (en) | 1981-03-18 |
DK150064B (en) | 1986-12-01 |
DK182379A (en) | 1979-11-09 |
PL215420A1 (en) | 1980-02-11 |
NO150639B (en) | 1984-08-13 |
NO791477L (en) | 1979-11-09 |
JPS54154760A (en) | 1979-12-06 |
EP0005689A1 (en) | 1979-11-28 |
SU1093245A3 (en) | 1984-05-15 |
GR67631B (en) | 1981-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |