ATE279415T1 - ANTIDEPRESSIVE AZAHETEROCYCLYMETHYL DERIVATIVES OF OXAHETEROCYCYL-ANNELLATED (1,4)-BENZODIOXANES - Google Patents

ANTIDEPRESSIVE AZAHETEROCYCLYMETHYL DERIVATIVES OF OXAHETEROCYCYL-ANNELLATED (1,4)-BENZODIOXANES

Info

Publication number
ATE279415T1
ATE279415T1 AT02728947T AT02728947T ATE279415T1 AT E279415 T1 ATE279415 T1 AT E279415T1 AT 02728947 T AT02728947 T AT 02728947T AT 02728947 T AT02728947 T AT 02728947T AT E279415 T1 ATE279415 T1 AT E279415T1
Authority
AT
Austria
Prior art keywords
oxaheterocycyl
azaheterocyclymethyl
benzodioxanes
annellated
antidepressive
Prior art date
Application number
AT02728947T
Other languages
German (de)
Inventor
Gary Paul Stack
Hong Gao
Elizabeth Suzanne Gildersleeve
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE279415T1 publication Critical patent/ATE279415T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Compounds of the formula useful for the treatment of depression such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses
AT02728947T 2001-04-26 2002-04-24 ANTIDEPRESSIVE AZAHETEROCYCLYMETHYL DERIVATIVES OF OXAHETEROCYCYL-ANNELLATED (1,4)-BENZODIOXANES ATE279415T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28656901P 2001-04-26 2001-04-26
PCT/US2002/012831 WO2002088135A1 (en) 2001-04-26 2002-04-24 Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans

Publications (1)

Publication Number Publication Date
ATE279415T1 true ATE279415T1 (en) 2004-10-15

Family

ID=23099201

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02728947T ATE279415T1 (en) 2001-04-26 2002-04-24 ANTIDEPRESSIVE AZAHETEROCYCLYMETHYL DERIVATIVES OF OXAHETEROCYCYL-ANNELLATED (1,4)-BENZODIOXANES

Country Status (12)

Country Link
US (1) US6552049B2 (en)
EP (1) EP1381613B1 (en)
JP (1) JP2004532236A (en)
CN (1) CN1503798A (en)
AT (1) ATE279415T1 (en)
BR (1) BR0209343A (en)
CA (1) CA2445543A1 (en)
DE (1) DE60201590T2 (en)
DK (1) DK1381613T3 (en)
ES (1) ES2229138T3 (en)
MX (1) MXPA03009825A (en)
WO (1) WO2002088135A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706736B2 (en) * 2001-04-26 2004-03-16 Wyeth Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans
US6911445B2 (en) 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
CA2560454C (en) 2004-03-30 2013-05-21 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of jak and other protein kinases
JP2005314260A (en) * 2004-04-28 2005-11-10 Japan Science & Technology Agency Method for producing flavone c glycoside
EP1856126A2 (en) * 2005-02-17 2007-11-21 Wyeth a Corporation of the State of Delaware Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
US8247421B2 (en) 2006-12-21 2012-08-21 Vertex Pharmaceuticals Incorporated 5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
CN104940202B (en) 2009-06-17 2018-10-16 沃泰克斯药物股份有限公司 Inhibitors of influenza viruses replication
CN103492381A (en) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 Inhibitors of influenza viruses replication
UA118010C2 (en) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед INFLUENCES OF INFLUENZA VIRUS REPLICATION
PL3068782T3 (en) 2013-11-13 2018-12-31 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
NZ719729A (en) 2013-11-13 2022-04-29 Vertex Pharma Inhibitors of influenza viruses replication
MA42422A (en) 2015-05-13 2018-05-23 Vertex Pharma INHIBITORS OF INFLUENZA VIRUS REPLICATION
JP6704416B2 (en) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Methods for preparing inhibitors of influenza virus replication

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (en) 1991-10-28 1993-04-29 Bayer Ag 2-AMINOMETHYL-chromans
DE4140540A1 (en) 1991-12-09 1993-06-17 Bayer Ag NEW AZAHETEROCYCLYLMETHYL-CHROMANE
EP0714396B1 (en) 1993-08-19 2003-12-10 Janssen Pharmaceutica N.V. Vasocontrictive dihydrobenzopyran derivatives
US5741789A (en) 1995-01-17 1998-04-21 Eli Lilly And Company Compounds having effects on serotonin-related systems
GB9526495D0 (en) 1995-12-23 1996-02-28 Knoll Ag Therapeutic agents
DK0932609T3 (en) 1996-10-15 2003-09-01 Wyeth Corp Azaheterocyclomethyl derivatives of 2,3,8,9-tetrahydro-7H-1,4-dioxino [2,3-e] indol-8-one
US5869490A (en) 1996-10-15 1999-02-09 American Home Products Corporation Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
GB9627005D0 (en) 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
GB9704948D0 (en) * 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
WO1999010346A1 (en) 1997-08-22 1999-03-04 Eli Lilly And Company Limited Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands
US6458802B1 (en) * 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline

Also Published As

Publication number Publication date
CA2445543A1 (en) 2002-11-07
BR0209343A (en) 2004-06-15
WO2002088135A1 (en) 2002-11-07
US20020183353A1 (en) 2002-12-05
DE60201590D1 (en) 2004-11-18
EP1381613B1 (en) 2004-10-13
MXPA03009825A (en) 2005-03-07
US6552049B2 (en) 2003-04-22
JP2004532236A (en) 2004-10-21
CN1503798A (en) 2004-06-09
ES2229138T3 (en) 2005-04-16
EP1381613A1 (en) 2004-01-21
DK1381613T3 (en) 2005-01-24
DE60201590T2 (en) 2005-02-17

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