ATE278693T1 - Zyklische verbindungen welche nukleotidebasen- spezifische wechselwirkung mit doppelsträngiger nukleinsäure eingehen - Google Patents

Zyklische verbindungen welche nukleotidebasen- spezifische wechselwirkung mit doppelsträngiger nukleinsäure eingehen

Info

Publication number
ATE278693T1
ATE278693T1 AT00903143T AT00903143T ATE278693T1 AT E278693 T1 ATE278693 T1 AT E278693T1 AT 00903143 T AT00903143 T AT 00903143T AT 00903143 T AT00903143 T AT 00903143T AT E278693 T1 ATE278693 T1 AT E278693T1
Authority
AT
Austria
Prior art keywords
double
compounds
stranded nucleic
enter
nucleic acid
Prior art date
Application number
AT00903143T
Other languages
English (en)
Inventor
Eldon E Baird
Peter B Dervan
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Application granted granted Critical
Publication of ATE278693T1 publication Critical patent/ATE278693T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
AT00903143T 1999-01-08 2000-01-06 Zyklische verbindungen welche nukleotidebasen- spezifische wechselwirkung mit doppelsträngiger nukleinsäure eingehen ATE278693T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11523299P 1999-01-08 1999-01-08
PCT/US2000/000298 WO2000040605A2 (en) 1999-01-08 2000-01-06 Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids

Publications (1)

Publication Number Publication Date
ATE278693T1 true ATE278693T1 (de) 2004-10-15

Family

ID=22360079

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00903143T ATE278693T1 (de) 1999-01-08 2000-01-06 Zyklische verbindungen welche nukleotidebasen- spezifische wechselwirkung mit doppelsträngiger nukleinsäure eingehen

Country Status (7)

Country Link
EP (1) EP1144414B1 (de)
JP (1) JP2002539077A (de)
AT (1) ATE278693T1 (de)
AU (1) AU2493100A (de)
CA (1) CA2358119A1 (de)
DE (1) DE60014579T2 (de)
WO (1) WO2000040605A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528620B1 (en) 1999-11-08 2003-03-04 University Of Utah Research Foundation Sid-polyamide fusions: a potent method of regulating gene expression
US7078536B2 (en) 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
KR20030043785A (ko) 2000-03-16 2003-06-02 젠소프트, 인크. 핵산 결합 부위를 포함하는 하전된 화합물 및 이의 용도
AU2003258022A1 (en) 2002-08-02 2004-02-23 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
WO2004039318A2 (en) 2002-10-25 2004-05-13 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
CA2508769A1 (en) 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
EP1599474B1 (de) * 2003-03-04 2013-04-24 California Institute Of Technology Heterocyclische oligomere Verbindungen zur DNS-Erkennung
CN1845733A (zh) * 2003-09-04 2006-10-11 学校法人日本大学 TGF－β基因表达抑制剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090947A (en) * 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
AU6757698A (en) * 1996-02-26 1998-10-30 California Institute Of Technology Stereochemical control of the dna binding affinity, sequence specificity, and orientation-preference of chiral hairpin polyamides in the minor groove
WO1998037066A1 (en) * 1996-02-26 1998-08-27 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded dna
EP0973740A1 (de) * 1996-02-26 2000-01-26 California Institute Of Technology Entwurf, synthese und verwendung von spezifischen dna-bindenden polyamid-liganden
CN1260006A (zh) * 1996-02-26 2000-07-12 加利福尼亚州技术学院 双链dna和杂环低聚物之间复合物的形成
AU749953B2 (en) * 1996-08-01 2002-07-04 California Institute Of Technology Inhibition of gene transcription by polyamide DNA-binding ligands
CA2286232A1 (en) * 1997-04-06 1998-11-05 California Institute Of Technology Dna-binding pyrrole and imidazole polyamide derivatives

Also Published As

Publication number Publication date
EP1144414A2 (de) 2001-10-17
DE60014579D1 (de) 2004-11-11
WO2000040605A9 (en) 2001-10-25
WO2000040605A2 (en) 2000-07-13
JP2002539077A (ja) 2002-11-19
EP1144414B1 (de) 2004-10-06
WO2000040605A3 (en) 2000-11-30
DE60014579T2 (de) 2006-03-09
AU2493100A (en) 2000-07-24
CA2358119A1 (en) 2000-07-13

Similar Documents

Publication Publication Date Title
Zhang et al. Smart and functionalized development of nucleic acid‐based hydrogels: Assembly strategies, recent advances, and challenges
Brodyagin et al. Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications
Shi et al. Responsive DNA-based supramolecular hydrogels
Sharma et al. Versatility of peptide nucleic acids (PNA s): Role in chemical biology, drug discovery, and origins of life
Xiang et al. Self-assembled DNA hydrogel based on enzymatically polymerized DNA for protein encapsulation and enzyme/DNAzyme hybrid cascade reaction
Ganesh et al. Peptide nucleic acids analogs and derivatives
Riccardi et al. Fluorescent thrombin binding aptamer-tagged nanoparticles for an efficient and reversible control of thrombin activity
Hnedzko et al. Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic nucleobase and backbone-modified peptide nucleic acids
Appukutti et al. High definition polyphosphoesters: between nucleic acids and plastics
US20210262017A1 (en) Sensors for nucleic acid biomarkers
AU2003234196A8 (en) Functionalized nanoparticles and methods of use
Stephanopoulos Peptide–oligonucleotide hybrid molecules for bioactive nanomaterials
Peng et al. From cells to DNA materials
Wu et al. Photoregulation between small DNAs and reversible photochromic molecules
Gupta et al. Structural design and synthesis of bimodal PNA that simultaneously binds two complementary DNAs to form fused double duplexes
DE3675481D1 (de) Verbindungen, enthaltend eine oligonukleotide sequenz, gebunden an eine interkalierungsverbindung und an eine aktivierbare chemische verbindung, ihre synthese und verwendungen als artifizielle sequenzspezifische nuklease.
Bhingardeve et al. Receptor-specific delivery of peptide nucleic acids conjugated to three sequentially linked N-acetyl galactosamine moieties into hepatocytes
DE60014579D1 (de) Zyklische verbindungen welche nukleotidebasen-spezifische wechselwirkung mit doppelsträngiger nukleinsäure eingehen
De Rochambeau et al. Modular strategy to expand the chemical diversity of DNA and sequence-controlled polymers
EP1246616A4 (de) Zelldurchlässige peptide zur inhibierung von entzündungsreaktionen und deren verwendung
López-Tena et al. Pseudo-Complementary G: C Base Pair for Mixed Sequence dsDNA Invasion and Its Applications in Diagnostics (SARS-CoV-2 Detection)
Musumeci et al. DNA-and RNA-binding ability of oligoDapT, a nucleobase-decorated peptide, for biomedical applications
Ganesh et al. Nucleic acids–chemistry and applications
ATE342271T1 (de) 2-azapurine verbindungen und ihre verwendung
Schmidt et al. Monofunctionally trans‐Diammine Platinum (ii)‐Modified Peptide Nucleic Acid Oligomers: A New Generation of Potential Antisense Drugs

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties