ATE258T1 - PROCESS FOR THE MANUFACTURE OF 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOCHINOLINE AND INTERMEDIATE PRODUCTS. - Google Patents

PROCESS FOR THE MANUFACTURE OF 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOCHINOLINE AND INTERMEDIATE PRODUCTS.

Info

Publication number
ATE258T1
ATE258T1 AT79102847T AT79102847T ATE258T1 AT E258 T1 ATE258 T1 AT E258T1 AT 79102847 T AT79102847 T AT 79102847T AT 79102847 T AT79102847 T AT 79102847T AT E258 T1 ATE258 T1 AT E258T1
Authority
AT
Austria
Prior art keywords
tetrahydroisochinoline
dichloro
manufacture
intermediate products
products
Prior art date
Application number
AT79102847T
Other languages
German (de)
Inventor
Bing Lun Lam
Wilford Lee Mendelson
Charles Barton Spainhour Jr
Original Assignee
Smithkline Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corporation filed Critical Smithkline Corporation
Application granted granted Critical
Publication of ATE258T1 publication Critical patent/ATE258T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT79102847T 1978-08-10 1979-08-07 PROCESS FOR THE MANUFACTURE OF 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOCHINOLINE AND INTERMEDIATE PRODUCTS. ATE258T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/932,586 US4251660A (en) 1978-08-10 1978-08-10 Method for preparing tetrahydroisoquinolines
EP79102847A EP0008405B1 (en) 1978-08-10 1979-08-07 Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline and n-chloroethyl-, n-bromoethyl- or n-hydroxyethyl-2,3-dichlorobenzylamine intermediate

Publications (1)

Publication Number Publication Date
ATE258T1 true ATE258T1 (en) 1981-10-15

Family

ID=25462546

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79102847T ATE258T1 (en) 1978-08-10 1979-08-07 PROCESS FOR THE MANUFACTURE OF 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOCHINOLINE AND INTERMEDIATE PRODUCTS.

Country Status (29)

Country Link
US (1) US4251660A (en)
EP (1) EP0008405B1 (en)
JP (1) JPS5524196A (en)
AR (1) AR220218A1 (en)
AT (1) ATE258T1 (en)
AU (1) AU522843B2 (en)
BG (1) BG32714A3 (en)
CA (1) CA1130290A (en)
CS (1) CS226006B2 (en)
DD (1) DD145532A5 (en)
DE (1) DE2961141D1 (en)
DK (1) DK330579A (en)
ES (1) ES483151A1 (en)
FI (1) FI65062C (en)
GR (1) GR69853B (en)
HU (1) HU178110B (en)
IE (1) IE48618B1 (en)
IL (1) IL57980A (en)
IN (1) IN152421B (en)
IT (1) IT1227791B (en)
MX (1) MX5581E (en)
NO (1) NO153807C (en)
NZ (1) NZ191227A (en)
PH (1) PH24441A (en)
PL (1) PL217684A1 (en)
PT (1) PT70029A (en)
RO (1) RO78160A (en)
SU (1) SU860698A3 (en)
ZA (1) ZA793308B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0161350A1 (en) * 1981-11-27 1985-11-21 Smithkline Beckman Corporation Process for preparing benzazepines
US4541954A (en) * 1984-09-05 1985-09-17 Smithkline Beckman Corporation Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2771468A (en) * 1954-02-19 1956-11-20 Sterling Drug Inc 4-aralkyl-3-morpholones, 4-aralkyl-3-homomorpholones and their preparation
US3947456A (en) * 1970-01-06 1976-03-30 Hoffman-La Roche Inc. Substituted 4-phenyl isoquinolines
US3752892A (en) * 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof

Also Published As

Publication number Publication date
NO792601L (en) 1980-02-12
ES483151A1 (en) 1980-04-16
IE48618B1 (en) 1985-03-20
DK330579A (en) 1980-02-11
ZA793308B (en) 1980-09-24
RO78160A (en) 1982-02-01
JPS5524196A (en) 1980-02-21
IN152421B (en) 1984-01-07
CA1130290A (en) 1982-08-24
US4251660A (en) 1981-02-17
FI65062C (en) 1984-03-12
AU4954779A (en) 1980-02-14
PL217684A1 (en) 1980-06-16
EP0008405A2 (en) 1980-03-05
IE791534L (en) 1980-02-10
HU178110B (en) 1982-03-28
PH24441A (en) 1990-06-25
NZ191227A (en) 1981-10-19
GR69853B (en) 1982-07-19
FI65062B (en) 1983-11-30
IT1227791B (en) 1991-05-07
NO153807B (en) 1986-02-17
MX5581E (en) 1983-10-26
IT7924894A0 (en) 1979-08-02
CS226006B2 (en) 1984-03-19
AR220218A1 (en) 1980-10-15
PT70029A (en) 1979-09-01
BG32714A3 (en) 1982-09-15
NO153807C (en) 1986-05-28
IL57980A (en) 1984-08-31
DE2961141D1 (en) 1981-12-10
FI792436A (en) 1980-02-11
IL57980A0 (en) 1979-12-30
AU522843B2 (en) 1982-07-01
EP0008405A3 (en) 1980-04-30
EP0008405B1 (en) 1981-09-30
DD145532A5 (en) 1980-12-17
SU860698A3 (en) 1981-08-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee