ATE25684T1 - Verfahren zur herstellung von biopterin und dessen derivaten. - Google Patents
Verfahren zur herstellung von biopterin und dessen derivaten.Info
- Publication number
- ATE25684T1 ATE25684T1 AT82110366T AT82110366T ATE25684T1 AT E25684 T1 ATE25684 T1 AT E25684T1 AT 82110366 T AT82110366 T AT 82110366T AT 82110366 T AT82110366 T AT 82110366T AT E25684 T1 ATE25684 T1 AT E25684T1
- Authority
- AT
- Austria
- Prior art keywords
- biopterin
- diacyl
- tetrahydro
- prepared
- derivatives
- Prior art date
Links
- LHQIJBMDNUYRAM-UHFFFAOYSA-N L-erythro-Biopterin Natural products N1=C(N)NC(=O)C2=NC(C(O)C(O)C)=CN=C21 LHQIJBMDNUYRAM-UHFFFAOYSA-N 0.000 title 1
- LHQIJBMDNUYRAM-DZSWIPIPSA-N L-erythro-biopterin Chemical compound N1=C(N)NC(=O)C2=NC([C@@H](O)[C@@H](O)C)=CN=C21 LHQIJBMDNUYRAM-DZSWIPIPSA-N 0.000 title 1
- 201000011252 Phenylketonuria Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000008499 blood brain barrier function Effects 0.000 abstract 1
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 150000002429 hydrazines Chemical class 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 108010064332 quinonoid dihydropterin reductase Proteins 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56182948A JPS5883691A (ja) | 1981-11-13 | 1981-11-13 | １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法 |
| EP82110366A EP0079574B1 (de) | 1981-11-13 | 1982-11-10 | Verfahren zur Herstellung von Biopterin und dessen Derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE25684T1 true ATE25684T1 (de) | 1987-03-15 |
Family
ID=16127151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82110366T ATE25684T1 (de) | 1981-11-13 | 1982-11-10 | Verfahren zur herstellung von biopterin und dessen derivaten. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4540783A (de) |
| EP (1) | EP0079574B1 (de) |
| JP (1) | JPS5883691A (de) |
| AT (1) | ATE25684T1 (de) |
| CA (1) | CA1208218A (de) |
| DE (1) | DE3275546D1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5976086A (ja) * | 1982-09-20 | 1984-04-28 | ザ ウエルカム フアウンデ−シヨン リミテツド | プテリジン化合物 |
| AU572792B2 (en) * | 1982-09-20 | 1988-05-19 | Wellcome Foundation Limited, The | 2-amino, 4-oxo-pteridine derivatives |
| GB8318833D0 (en) * | 1983-07-12 | 1983-08-10 | Wellcome Found | Chemical compounds |
| JPS59112987A (ja) * | 1982-12-20 | 1984-06-29 | Kanegafuchi Chem Ind Co Ltd | １′，２′―ジアシル―（６ｒ，ｓ）―５，６，７，８―テトラヒドロ―ｌ―ビオプテリンおよびその製法 |
| JPS60178887A (ja) * | 1984-02-23 | 1985-09-12 | Kanegafuchi Chem Ind Co Ltd | ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法 |
| JPS60199889A (ja) * | 1984-03-24 | 1985-10-09 | Kanegafuchi Chem Ind Co Ltd | ５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法 |
| US4550109A (en) * | 1984-05-31 | 1985-10-29 | The Board Of Regents, The University Of Texas System | Lipoidal biopterin compounds |
| US4665176A (en) * | 1984-10-23 | 1987-05-12 | Mitsui Toatsu Chemicals, Incorporated | Process for the preparation of 5,6,7,8-tetrahydrofolic acid |
| CA1334654C (en) * | 1987-11-30 | 1995-03-07 | Masayasu Kurono | Intermediates for synthesizing bh _and its derivatives |
| JP2843592B2 (ja) * | 1989-02-28 | 1999-01-06 | 日清製粉株式会社 | Ｌ−リボース誘導体 |
| US6162914A (en) * | 1998-04-24 | 2000-12-19 | Cerbios-Pharma S.A. | Process for the reduction of pterins |
| US7442372B2 (en) | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| CN1894251B (zh) * | 2003-11-17 | 2011-06-29 | 默克和西伊公司 | (6r)-l-赤型-四氢生物蝶呤二盐酸盐的晶型 |
| AU2012200512C1 (en) * | 2003-11-17 | 2020-04-30 | Merck & Cie | Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride |
| KR20070005550A (ko) * | 2003-11-17 | 2007-01-10 | 바이오마린 파머수티컬 인크. | 대사 장애 치료를 위한 조성물 및 방법 |
| BRPI0517088A (pt) | 2004-11-17 | 2008-09-30 | Biomarin Pharm Inc | formulação de comprimido estável |
| EP1819340A2 (de) * | 2004-12-08 | 2007-08-22 | Biomarin Pharmaceutical Inc. | Verfahren und zusammensetzungen zur behandlung von lungenhypertonie bei neugeborenen |
| US7361759B2 (en) | 2004-12-27 | 2008-04-22 | Shiratori Pharmaceutical Co., Ltd | Method for producing L-biopterin |
| AU2006321942A1 (en) * | 2005-12-05 | 2007-06-14 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of disease |
| JP4946391B2 (ja) * | 2006-11-28 | 2012-06-06 | ダイキン工業株式会社 | 熱交換器およびこれを備える空調ユニット |
| WO2008089148A1 (en) * | 2007-01-12 | 2008-07-24 | Biomarin Pharmaceutical Inc. | Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug |
| JP2010515747A (ja) * | 2007-01-12 | 2010-05-13 | ビオマリン プハルマセウトイカル インコーポレイテッド | テトラヒドロビオプテリンプロドラッグ |
| SI3461503T1 (sl) | 2007-04-11 | 2022-04-29 | Biomarin Pharmaceutical Inc. | Postopki za dajanje tetrahidrobiopterina, povezani sestavki in postopki merjenja |
| WO2009088530A1 (en) | 2008-01-03 | 2009-07-16 | Biomarin Pharmaceutical Inc. | Pterin analog for treating bh4 responsive condition |
| WO2009088979A1 (en) | 2008-01-07 | 2009-07-16 | Biomarin Pharmaceutical Inc. | Method of synthesizing tetrahydrobiopterin |
| US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
| WO2019175332A1 (en) | 2018-03-14 | 2019-09-19 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity |
| WO2019175328A1 (en) | 2018-03-14 | 2019-09-19 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Bh4pathwayactivationandusethereoffortreatingcancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH500999A (de) * | 1967-04-07 | 1970-12-31 | Ciba Geigy Ag | Verfahren zur Herstellung von Pterinderivaten |
| US3505329A (en) * | 1968-02-06 | 1970-04-07 | Smithkline Corp | Process for the synthesis of biopterin |
-
1981
- 1981-11-13 JP JP56182948A patent/JPS5883691A/ja active Pending
-
1982
- 1982-11-10 AT AT82110366T patent/ATE25684T1/de not_active IP Right Cessation
- 1982-11-10 DE DE8282110366T patent/DE3275546D1/de not_active Expired
- 1982-11-10 CA CA000415245A patent/CA1208218A/en not_active Expired
- 1982-11-10 EP EP82110366A patent/EP0079574B1/de not_active Expired
- 1982-11-15 US US06/441,736 patent/US4540783A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5883691A (ja) | 1983-05-19 |
| EP0079574B1 (de) | 1987-03-04 |
| EP0079574A1 (de) | 1983-05-25 |
| US4540783A (en) | 1985-09-10 |
| CA1208218A (en) | 1986-07-22 |
| DE3275546D1 (en) | 1987-04-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3275546D1 (en) | Process for preparing biopterin and its derivatives | |
| ATE120961T1 (de) | Konzentrate von aktiven verbindungen und kombinationen von aktiven verbindungen, ihre verfahren zur herstellung und arzneimittel, die die konzentrate oder die kombinationen enthalten. | |
| DE3483629D1 (de) | 2-pyrimidinyl-l-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. | |
| ZA934550B (en) | Derivatives in the vitamin D series with modifications in 20-position, process for their production,intermediate products for this process,pharmaceutical prepartions containing these derivatives as well as their use for the production of pharmaceutical agents | |
| DE3581566D1 (de) | Oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte. | |
| ATE48417T1 (de) | Pyridazin-derivate, wirksam auf das zentralnervensystem, verfahren zur herstellung, und diese enthaltende arzneimittel. | |
| AT338525B (de) | Verfahren zur herstellung von copolyamiden enthaltend caprolactam, laurinlactam und 11-aminoundecansaure | |
| ATE63913T1 (de) | Pyrazolo(3,4-b)pyridinderivate und verfahren zu ihrer herstellung. | |
| ATE68488T1 (de) | 1-(4-hydroxy-3,5-di-tert.-butyl-benzoyl)homopiperazin, verschiedene von dessen derivaten, verfahren zur herstellung dieser verbindungen, die sie enthaltenden arzneimittel und ihre verwendung. | |
| DE3887246D1 (de) | Verfahren zur Herstellung von Glutamin-Derivaten. | |
| DE3884870D1 (de) | Verfahren zur Herstellung von Vitamin-D-Derivaten. | |
| HU911140D0 (en) | Process for producing cyclo-alkano-(b)-dihydro-indole derivatives and their sulfonamides as well as pharmaceutical preparatives containing said compounds | |
| DE69009682D1 (de) | Verfahren zur Herstellung von Cyclohexanolderivaten. | |
| DE3880953D1 (de) | Chinolinderivate, verfahren zur herstellung davon und diese enthaltendes antibakterielles mittel. | |
| DE3774273D1 (de) | Chinazolin-derivat, verfahren zu dessen herstellung und mittel zur behandlung von cerebraler disfunktion als aktiver inhaltsstoff. | |
| DE3787437D1 (de) | Sialosylcholesterol, verfahren zu dessen herstellung und arzneimittel zur behandlung von krankheiten des nervensystems. | |
| ATE173735T1 (de) | Thiomarinol-derivate und verfahren zu ihrer herstellung | |
| ATA1034174A (de) | Verfahren zur herstellung von neuen 5:6-benzo-delta-pyron-derivaten bzw. von pharmazeutisch annehmbaren salzen und von optischen isomeren hievon | |
| DE59308617D1 (de) | 9-chlor-prostaglandin-ester und -amide und ihre verwendung für die herstellung von arzneimitteln | |
| DE59309380D1 (de) | Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsäure | |
| ATE65778T1 (de) | 4-oxo-thiazolidin-2-yliden-acetamid-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel zur bekaempfung von erkrankungen des zentralnervensystems. | |
| AT310171B (de) | Verfahren zur Herstellung des neuen 1-Vetratryl-4-methyl-5-äthyl-7,8-dimethoxy-2,3-diazabicyclo[5.4.0]undecapentaens-(1,3,6,8,10) und seiner Säureadditionssalze | |
| EP0302303A3 (de) | Bizyklische Verbindungen, ihre Verwendung als Pharmazeutika, ihre Herstellung und Zwischenprodukte zu ihrer Herstellung | |
| AT301567B (de) | Verfahren zur Herstellung des neuen 4,4-Dimethyl-5-thia-2,7-diazabicyclo[4,2,0]oct-2-en-8-ons | |
| DE68915750D1 (de) | Kathecholverbindungen, verfahren zur herstellung und arzneimittelzubereitung, die diese enthält. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |