ATE256147T1 - PEPTIDES AGAINST FUNGI - Google Patents

PEPTIDES AGAINST FUNGI

Info

Publication number
ATE256147T1
ATE256147T1 AT95928105T AT95928105T ATE256147T1 AT E256147 T1 ATE256147 T1 AT E256147T1 AT 95928105 T AT95928105 T AT 95928105T AT 95928105 T AT95928105 T AT 95928105T AT E256147 T1 ATE256147 T1 AT E256147T1
Authority
AT
Austria
Prior art keywords
peptides
amino acids
against fungi
peptides against
wlqlf
Prior art date
Application number
AT95928105T
Other languages
German (de)
Inventor
Roger G Ii Little
Edward Lim
Mitchell B Fadem
Original Assignee
Xoma Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/306,473 external-priority patent/US5652332A/en
Priority claimed from US08/372,105 external-priority patent/US5627153A/en
Application filed by Xoma Technology Ltd filed Critical Xoma Technology Ltd
Application granted granted Critical
Publication of ATE256147T1 publication Critical patent/ATE256147T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates generally to anti-fungal peptides derived from or based on Domain III (amino acids 142-169) of bactericidal/permeability-increasing protein (BPI) and therapeutic uses of such peptides. The mentioned peptides all have from seven to twelve amino acids and comprise a core sequence of LIQL, IQLF, WLIQL, LIQLF and WLQLF and one or more basic amino acids in the terminal regions. Peptides are either linear or cyclic.
AT95928105T 1994-09-15 1995-07-20 PEPTIDES AGAINST FUNGI ATE256147T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/306,473 US5652332A (en) 1993-03-12 1994-09-15 Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
US08/372,105 US5627153A (en) 1994-01-14 1995-01-13 Anti-fungal methods and materials
PCT/US1995/009262 WO1996008509A1 (en) 1994-09-15 1995-07-20 Anti-fungal peptides

Publications (1)

Publication Number Publication Date
ATE256147T1 true ATE256147T1 (en) 2003-12-15

Family

ID=26975179

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95928105T ATE256147T1 (en) 1994-09-15 1995-07-20 PEPTIDES AGAINST FUNGI

Country Status (7)

Country Link
EP (1) EP0824547B1 (en)
JP (1) JPH10508576A (en)
AT (1) ATE256147T1 (en)
AU (1) AU709738B2 (en)
CA (1) CA2200069C (en)
DE (1) DE69532302D1 (en)
WO (1) WO1996008509A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652332A (en) * 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
WO1997004008A1 (en) * 1995-07-20 1997-02-06 Xoma Corporation Anti-fungal peptides
NZ332720A (en) * 1996-05-10 2000-07-28 Xoma Corp Therapeutic uses of bactericidal/permeability increasing (BPI) protein to treat human meningococcemia
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
AU736096B2 (en) * 1996-05-23 2001-07-26 Xoma Corporation Therapeutic uses of BPI protein products in humans with hemorrhage due to trauma
US5888973A (en) 1996-08-09 1999-03-30 Xoma Corporation Anti-chlamydial uses of BPI protein products
US6482796B2 (en) 1996-11-01 2002-11-19 Xoma Corporation Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US6093573A (en) * 1997-06-20 2000-07-25 Xoma Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
US6013631A (en) * 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
WO2000018798A1 (en) * 1998-09-25 2000-04-06 Xoma Technology Ltd. Antifungal and antibacterial peptide
US6242219B1 (en) 1999-03-18 2001-06-05 Xoma (Us) Llc Methods for recombinant peptide production
US6355616B1 (en) 1999-06-25 2002-03-12 Xoma (Us) Technology Ltd. Derivative compounds derived from or based on bactericidal/permeability-increasing protein
DK1492874T3 (en) 2002-03-29 2011-03-14 Xoma Technology Ltd Multigene vector plasmids and methods for enhancing the expression of recombinant polypeptides
GB201319620D0 (en) 2013-11-06 2013-12-18 Norwegian University Of Science And Technology Immunosuppressive agents and their use in therapy
GB201319621D0 (en) 2013-11-06 2013-12-18 Norwegian University Of Science And Technology Antimicrobial agents and their use in therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2157981T3 (en) * 1993-03-12 2001-09-01 Xoma Technology Ltd THERAPEUTIC USES OF BACTERICIDIC / PERMEABILITY PROTEIN PRODUCTS.
ES2123134T3 (en) * 1993-03-12 1999-01-01 Xoma Corp BIOLOGICALLY ACTIVE PEPTIDES OF FUNCTIONAL DOMAINS OF PERMEABILITY-INCREASING BACTERICIDE PROTEIN AND USES THEREOF.
US5733872A (en) * 1993-03-12 1998-03-31 Xoma Corporation Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
CN1112933C (en) * 1994-01-14 2003-07-02 爱克索马技术有限公司 Antifungal method and substance

Also Published As

Publication number Publication date
CA2200069A1 (en) 1996-03-21
JPH10508576A (en) 1998-08-25
EP0824547B1 (en) 2003-12-10
CA2200069C (en) 2000-09-26
AU3198195A (en) 1996-03-29
EP0824547A1 (en) 1998-02-25
AU709738B2 (en) 1999-09-02
DE69532302D1 (en) 2004-01-22
WO1996008509A1 (en) 1996-03-21

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties