ATE243698T1 - 1,2-DIHYDRO-1-OXO-PYRAZINO(1,2-)INDOLE DERIVATIVES - Google Patents
1,2-DIHYDRO-1-OXO-PYRAZINO(1,2-)INDOLE DERIVATIVESInfo
- Publication number
- ATE243698T1 ATE243698T1 AT00949428T AT00949428T ATE243698T1 AT E243698 T1 ATE243698 T1 AT E243698T1 AT 00949428 T AT00949428 T AT 00949428T AT 00949428 T AT00949428 T AT 00949428T AT E243698 T1 ATE243698 T1 AT E243698T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrazino
- dihydro
- oxo
- indole derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Compounds of formula (I) wherein R, R1, X and Y have the meanings defined in the disclosure, have antitumor activity against solid tumors.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001741A IT1313593B1 (en) | 1999-08-03 | 1999-08-03 | 1,2-DIIDRO-1-OXO-PIRAZINO 1,2-A INDOL DERIVATIVES. |
PCT/EP2000/007418 WO2001009136A1 (en) | 1999-08-03 | 2000-07-31 | 1,2-dihydro-1-oxo-pyrazino[1,2-a]indole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE243698T1 true ATE243698T1 (en) | 2003-07-15 |
Family
ID=11383491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00949428T ATE243698T1 (en) | 1999-08-03 | 2000-07-31 | 1,2-DIHYDRO-1-OXO-PYRAZINO(1,2-)INDOLE DERIVATIVES |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1200439B1 (en) |
JP (1) | JP2003506376A (en) |
AT (1) | ATE243698T1 (en) |
AU (1) | AU6278700A (en) |
CA (1) | CA2393915A1 (en) |
DE (1) | DE60003560D1 (en) |
IT (1) | IT1313593B1 (en) |
WO (1) | WO2001009136A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8207165B2 (en) * | 2008-03-28 | 2012-06-26 | Nerviano Medical Sciences S.R.L. | 3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
AU2013232069B2 (en) | 2012-03-16 | 2017-07-13 | Vitae Pharmaceuticals, Inc. | Liver X receptor modulators |
CN104203951B (en) | 2012-03-16 | 2016-11-02 | 生命医药公司 | Liver X receptor modifier |
CR20170572A (en) | 2015-06-17 | 2018-03-20 | Pfizer | TRICYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07507574A (en) * | 1993-04-05 | 1995-08-24 | 藤沢薬品工業株式会社 | Indole derivatives for testosterone 5α-reductase inhibitors |
-
1999
- 1999-08-03 IT IT1999MI001741A patent/IT1313593B1/en active
-
2000
- 2000-07-31 AU AU62787/00A patent/AU6278700A/en not_active Abandoned
- 2000-07-31 EP EP20000949428 patent/EP1200439B1/en not_active Expired - Lifetime
- 2000-07-31 CA CA002393915A patent/CA2393915A1/en not_active Abandoned
- 2000-07-31 JP JP2001514339A patent/JP2003506376A/en active Pending
- 2000-07-31 WO PCT/EP2000/007418 patent/WO2001009136A1/en active IP Right Grant
- 2000-07-31 AT AT00949428T patent/ATE243698T1/en not_active IP Right Cessation
- 2000-07-31 DE DE60003560T patent/DE60003560D1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ITMI991741A1 (en) | 2001-02-03 |
EP1200439A1 (en) | 2002-05-02 |
AU6278700A (en) | 2001-02-19 |
CA2393915A1 (en) | 2001-02-08 |
IT1313593B1 (en) | 2002-09-09 |
WO2001009136A1 (en) | 2001-02-08 |
EP1200439B1 (en) | 2003-06-25 |
JP2003506376A (en) | 2003-02-18 |
ITMI991741A0 (en) | 1999-08-03 |
DE60003560D1 (en) | 2003-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1070056T3 (en) | Phthalazinone PDE III / IV Inhibitors | |
AU7779900A (en) | Trifluoromethyl-substituted spirocyclic ketoenols | |
PT1140944E (en) | EPOTILONE DERIVATIVES AND THEIR USE AS ANTITUMATIC AGENTS | |
HK1038354A1 (en) | Indole derivatives and their use in the treatment of malignant and other diseases caused by pathological cell proliferation. | |
YU21401A (en) | Tetrahydropyridoethers | |
PT998460E (en) | NEW TETRAZOLE DERIVATIVES | |
IT1315267B1 (en) | DERIVATIVES OF 2- (1H-INDOL-3-IL) -2-OXO-ACETAMIDES FOR ANTI-TUMOR ACTIVITY | |
ATE311389T1 (en) | PRECURSOR OF IMIDAZOPYRIDINE DERIVATIVES | |
DE59909760D1 (en) | BENZONAPHTHYRIDINE-N-OXIDES WITH PDE3 AND PDE4 INHIBITING ACTIVITY | |
TR200201128T2 (en) | Tetrahydrothiopyraniphalazinone derivatives as PDE4 inhibitors. | |
ATE259813T1 (en) | TRIAZOLOPYRIMIDE DERIVATIVES | |
TR200001909T2 (en) | Matrix metalloprosthesis inhibitors. | |
ATE374189T1 (en) | PHTHALAZINONE DERIVATIVES AS PDE 4 INHIBITORS | |
AU2002211493A1 (en) | Indole derivatives as pde5-inhibitors | |
ATE243698T1 (en) | 1,2-DIHYDRO-1-OXO-PYRAZINO(1,2-)INDOLE DERIVATIVES | |
TR200100133T2 (en) | FKBP Inhibitors | |
TR200402322T4 (en) | Tryptase inhibitors | |
DE60026350D1 (en) | DIARYL PIPERIDYL-PYRROL DERIVATIVES AS ANTIPROTRO-TOZENES | |
TR200200017T2 (en) | Benzofuran derivatives | |
SI1244614T1 (en) | Tryptase inhibitors | |
PT1104419E (en) | AZABICYCLOHEPTAN DERIVATIVES SUBSTITUTED IN NITROGEN ITS PREPARATION AND UTILIZATION | |
ES2159489A1 (en) | Novel imidazole derivatives with anti-inflammatory activity | |
ATE282611T1 (en) | STOLONOXIDES | |
AP2001002047A0 (en) | Isoquinoliness as urokinase inhibitors. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |