ATE225T1 - NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE-(2), THEIR ACID ADDITIONAL SALTS, MEDICATIONS CONTAINING THEM AND PROCESSES FOR THE MANUFACTURE OF SAME. - Google Patents

NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE-(2), THEIR ACID ADDITIONAL SALTS, MEDICATIONS CONTAINING THEM AND PROCESSES FOR THE MANUFACTURE OF SAME.

Info

Publication number
ATE225T1
ATE225T1 AT79101924T AT79101924T ATE225T1 AT E225 T1 ATE225 T1 AT E225T1 AT 79101924 T AT79101924 T AT 79101924T AT 79101924 T AT79101924 T AT 79101924T AT E225 T1 ATE225 T1 AT E225T1
Authority
AT
Austria
Prior art keywords
imidazoline
phenylamino
manufacture
processes
same
Prior art date
Application number
AT79101924T
Other languages
German (de)
Inventor
Helmut Dr. Staehle
Herbert Dr. Koeppe
Werner Dr. Kummer
Wolfgang Dr. Hoefke
Original Assignee
C.H. Boehringer Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn filed Critical C.H. Boehringer Sohn
Application granted granted Critical
Publication of ATE225T1 publication Critical patent/ATE225T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compounds of the formula <IMAGE> where Ar represents a radical selected from the group consisting of 2,6-dichlorophenyl, 2,5-dichlorophenyl, 2-chloro-6-methylphenyl, 2-chloro-4-methylphenyl, 2,6-dichloro-4-bromophenyl, 4-cyanophenyl, 2,5-dimethoxyphenyl, and 2-methyl-5-fluorophenyl, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.
AT79101924T 1978-07-15 1979-06-13 NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE-(2), THEIR ACID ADDITIONAL SALTS, MEDICATIONS CONTAINING THEM AND PROCESSES FOR THE MANUFACTURE OF SAME. ATE225T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782831143 DE2831143A1 (en) 1978-07-15 1978-07-15 NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF

Publications (1)

Publication Number Publication Date
ATE225T1 true ATE225T1 (en) 1981-10-15

Family

ID=6044451

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101924T ATE225T1 (en) 1978-07-15 1979-06-13 NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE-(2), THEIR ACID ADDITIONAL SALTS, MEDICATIONS CONTAINING THEM AND PROCESSES FOR THE MANUFACTURE OF SAME.

Country Status (5)

Country Link
US (1) US4239764A (en)
EP (1) EP0007986B1 (en)
JP (1) JPS5515482A (en)
AT (1) ATE225T1 (en)
DE (2) DE2831143A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2951601A1 (en) * 1979-12-21 1981-07-02 C.H. Boehringer Sohn, 6507 Ingelheim NEW SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759048A (en) * 1969-11-17 1971-05-17 Boehringer Sohn Ingelheim NEW N-AMINOALCOYL-ARYLAMINO-IMIDAZOLINES- (2) SUBSTITUTES AND METHODS FOR MAKING THEM
US3850926A (en) * 1971-01-21 1974-11-26 Boehringer Sohn Ingelheim 2-(n-substituted-phenylamino)-imidazolines-(2)
DE2220906A1 (en) * 1972-04-28 1973-11-15 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE- (2), THEIR ACID-ADDITIONAL SALTS AND PROCESS FOR THEIR PRODUCTION

Also Published As

Publication number Publication date
EP0007986B1 (en) 1981-09-16
JPS5515482A (en) 1980-02-02
US4239764A (en) 1980-12-16
DE2831143A1 (en) 1980-01-31
DE2960824D1 (en) 1981-12-03
EP0007986A1 (en) 1980-02-20

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