ATE217789T1 - PLEASANT TASTING PHARMACEUTICAL COMPOSITIONS - Google Patents

PLEASANT TASTING PHARMACEUTICAL COMPOSITIONS

Info

Publication number
ATE217789T1
ATE217789T1 AT93914418T AT93914418T ATE217789T1 AT E217789 T1 ATE217789 T1 AT E217789T1 AT 93914418 T AT93914418 T AT 93914418T AT 93914418 T AT93914418 T AT 93914418T AT E217789 T1 ATE217789 T1 AT E217789T1
Authority
AT
Austria
Prior art keywords
pct
drug
sec
date
coated
Prior art date
Application number
AT93914418T
Other languages
German (de)
Inventor
Sanjay Bhardwaj
Marshall St George S A Hayward
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE217789T1 publication Critical patent/ATE217789T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PCT No. PCT/US93/05423 Sec. 371 Date Feb. 15, 1995 Sec. 102(e) Date Feb. 15, 1995 PCT Filed Jun. 4, 1993 PCT Pub. No. WO93/24109 PCT Pub. Date Dec. 9, 1993A pharmaceutical granular composition and method are provided for masking the taste of unpleasant tasting drugs, wherein drug cores are coated with separate layers of aqueous dispersions of methacrylate ester copolymers, preferably, poly(ethylacrylate, methyl methacrylate) to which quaternary ammonium groups have been introduced to modify the permeability of the ester. Additionally, the coating composition may contain plasticizers and conventional excipients. The coating system releases drug by diffusion and is influenced by drug solubility and media pH. The coated pharmaceutical granules of the invention can be used to prepare chewable tablets with good palatability and bioavailability.
AT93914418T 1992-06-04 1993-06-04 PLEASANT TASTING PHARMACEUTICAL COMPOSITIONS ATE217789T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89328892A 1992-06-04 1992-06-04
PCT/US1993/005423 WO1993024109A1 (en) 1992-06-04 1993-06-04 Palatable pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ATE217789T1 true ATE217789T1 (en) 2002-06-15

Family

ID=25401342

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93914418T ATE217789T1 (en) 1992-06-04 1993-06-04 PLEASANT TASTING PHARMACEUTICAL COMPOSITIONS

Country Status (8)

Country Link
US (1) US5578316A (en)
EP (1) EP0650353B1 (en)
JP (1) JP3839467B2 (en)
AT (1) ATE217789T1 (en)
CA (1) CA2137265C (en)
DE (1) DE69331948T2 (en)
ES (1) ES2174849T3 (en)
WO (1) WO1993024109A1 (en)

Families Citing this family (47)

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US5837277A (en) * 1992-06-04 1998-11-17 Smithkline Beecham Corporation Palatable pharmaceutical compositions
AU1655595A (en) * 1994-04-29 1995-11-09 Mcneil-Ppc, Inc. Solid pharmaceutical dosage form containing flavored film coating
US5853756A (en) * 1995-01-11 1998-12-29 J. B. Chemicals & Pharmaceuticals Limited Controlled release formulations of Ranitidine
AUPN969796A0 (en) * 1996-05-07 1996-05-30 F.H. Faulding & Co. Limited Taste masked liquid suspensions
FR2752732B1 (en) * 1996-08-28 1998-11-20 Pf Medicament EXTENDED RELEASE GALENIC FORM OF MILNACIPRAN
EP1007012A4 (en) * 1996-10-01 2006-01-18 Cima Labs Inc Taste-masked microcapsule compositions and methods of manufacture
DE19648576C2 (en) * 1996-11-23 1999-08-12 Lohmann Therapie Syst Lts Lozenge for modified release of active substances in the gastrointestinal tract
UA65607C2 (en) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Pharmaceutical composition (variants) and process for its preparation
US8231899B2 (en) * 1998-09-10 2012-07-31 Nycomed Danmark Aps Quick release pharmaceutical compositions of drug substances
WO2000016742A1 (en) * 1998-09-24 2000-03-30 The Procter & Gamble Company Chewable compositions containing dextromethorphan
US6270807B1 (en) 1999-03-02 2001-08-07 L. Perrigo Company Taste-masked pharmaceutical composition
IN191482B (en) * 1999-03-19 2003-12-06 Ranbaxy Lab Ltd
WO2001035930A1 (en) * 1999-11-16 2001-05-25 Ranbaxy Laboratories Limited Taste masked oral compositions
WO2001064224A1 (en) * 2000-02-29 2001-09-07 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
JP2001253826A (en) * 2000-03-09 2001-09-18 Maruzen Pharmaceut Co Ltd Internal medicine
WO2002036126A1 (en) * 2000-10-30 2002-05-10 Lupin Limited Rapidly disintegrating sustained release cefuroxime axetil composition
ES2248291T3 (en) * 2001-02-27 2006-03-16 ROHM GMBH & CO. KG COATING AND BINDING AGENT FOR MEDICINAL FORMULATIONS WITH IMPROVED STORAGE STABILITY.
US7914811B2 (en) * 2001-06-29 2011-03-29 Mcneil-Ppc, Inc. Brittle-coating, soft core dosage form
US20050013862A1 (en) * 2001-09-05 2005-01-20 Vectura Limited Functional powders for oral delivery
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US7122143B2 (en) 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
CO5400144A1 (en) * 2002-03-11 2004-05-31 Novartis Ag ORGANIC COMPOUNDS
US20030220351A1 (en) * 2002-05-24 2003-11-27 Gilbert Gonzales Enteric coated caffeine tablet
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
BRPI0413881A (en) * 2003-08-28 2006-10-24 Sandoz Ag pharmaceutical composition comprising taste masking coating anticonvulsant
US20050181050A1 (en) * 2004-01-28 2005-08-18 Collegium Pharmaceutical, Inc. Dosage forms using drug-loaded ion exchange resins
US8609198B2 (en) * 2004-07-21 2013-12-17 Hewlett-Packard Development Company, L.P. Pharmaceutical dose form with a patterned coating and method of making the same
EP1846040A2 (en) * 2005-01-28 2007-10-24 Collegium Pharmaceutical, Inc. Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents
MX2008016416A (en) * 2006-06-19 2009-03-03 Mcneil Ppc Inc Enteric coated particles containing an active ingredient.
KR20130048725A (en) * 2010-03-15 2013-05-10 다이쇼 세이야꾸 가부시끼가이샤 Pigment composition
US9795576B2 (en) 2010-09-27 2017-10-24 Basf Se Protective coatings for acidic active ingredients
WO2012041788A1 (en) * 2010-09-27 2012-04-05 Basf Se Protective coatings for acidic active ingredients
HUE030062T2 (en) 2010-11-08 2017-04-28 Albireo Ab Ibat inhibitors for the treatment of liver diseases
EP2844297B1 (en) 2012-05-02 2018-08-15 Capsugel Belgium NV Aqueous dispersions of controlled release polymers and shells and capsules thereof
US20160256399A1 (en) 2013-11-04 2016-09-08 Capsugel Belgium Nv Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole
EP3110403B1 (en) 2014-02-25 2019-11-06 Orbis Biosciences, Inc. Taste masking drug formulations
WO2015199147A1 (en) 2014-06-25 2015-12-30 味の素株式会社 Solid preparation, and method for preventing or reducing discoloration thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
EP3664781A1 (en) 2017-08-09 2020-06-17 Albireo AB Cholestyramine granules, oral cholestyramine formulations and use thereof
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
BR112020024479A2 (en) 2018-06-20 2021-03-02 Albireo Ab crystalline hydrate, odevixibat crystalline modifications, mixed odevixibat solvate, use of odevixibat crystalline modification, process for the preparation of odevixibat crystalline modification, and pharmaceutical composition
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
US4800087A (en) * 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
JPS63188621A (en) * 1987-01-30 1988-08-04 Taisho Pharmaceut Co Ltd Flavor oral preparation
JPH07551B2 (en) * 1987-01-14 1995-01-11 久光製薬株式会社 Manufacturing method of microcapsule formulation
KR960011236B1 (en) * 1987-05-08 1996-08-21 스미스 클라인 앤드 프렌취 라보라토리스 리미티드 Pharmaceutical compositions of cimetidine
JPH0774151B2 (en) * 1987-10-12 1995-08-09 三井東圧化学株式会社 Process for producing powder which masks unpleasant organoleptic properties of drug
FR2624732B1 (en) * 1987-12-21 1991-02-15 Synthelabo SUSTAINED RELEASE PHARMACEUTICAL FORMULATION
ATE82680T1 (en) * 1988-05-04 1992-12-15 Smith Kline French Lab CHEWABLE TABLET.
US4925675A (en) * 1988-08-19 1990-05-15 Himedics, Inc. Erythromycin microencapsulated granules
DK0425699T3 (en) * 1989-05-11 1994-11-21 Chugai Pharmaceutical Co Ltd Oral preparation which may be released in a suitable area of the intestine
JPH0674206B2 (en) * 1989-12-28 1994-09-21 田辺製薬株式会社 Controlled release formulation and process for producing
JP2856485B2 (en) * 1990-03-07 1999-02-10 旭化成工業株式会社 Granule-containing tablets
US5084287A (en) * 1990-03-15 1992-01-28 Warner-Lambert Company Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat
US5075114A (en) * 1990-05-23 1991-12-24 Mcneil-Ppc, Inc. Taste masking and sustained release coatings for pharmaceuticals
CA2068402C (en) * 1991-06-14 1998-09-22 Michael R. Hoy Taste mask coatings for preparation of chewable pharmaceutical tablets

Also Published As

Publication number Publication date
WO1993024109A1 (en) 1993-12-09
EP0650353B1 (en) 2002-05-22
JPH07507549A (en) 1995-08-24
ES2174849T3 (en) 2002-11-16
JP3839467B2 (en) 2006-11-01
CA2137265A1 (en) 1993-12-09
CA2137265C (en) 2003-10-28
EP0650353A1 (en) 1995-05-03
DE69331948T2 (en) 2002-11-28
US5578316A (en) 1996-11-26
EP0650353A4 (en) 1996-02-28
DE69331948D1 (en) 2002-06-27

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Legal Events

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