ATE210662T1 - METHOD FOR PRODUCING EPOXIES - Google Patents

METHOD FOR PRODUCING EPOXIES

Info

Publication number
ATE210662T1
ATE210662T1 AT95911105T AT95911105T ATE210662T1 AT E210662 T1 ATE210662 T1 AT E210662T1 AT 95911105 T AT95911105 T AT 95911105T AT 95911105 T AT95911105 T AT 95911105T AT E210662 T1 ATE210662 T1 AT E210662T1
Authority
AT
Austria
Prior art keywords
epoxies
producing
epoxide
renin
proteases
Prior art date
Application number
AT95911105T
Other languages
German (de)
Inventor
David Askin
Kan K Eng
Peter E Maligres
Paul J Reider
Kai Rossen
Ralph P Volante
Veena Upadhyay
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE210662(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE210662T1 publication Critical patent/ATE210662T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Abstract

A process for synthesizing the epoxide of formula (I) consists of, at a minimum, formation of a halohydrin form the allyl acetonide reactant, followed by base-induced cyclization, the epoxide product (I) being useful as an intermediate for the synthesis of inhibitors of renin or HIV protease or other proteases.
AT95911105T 1994-03-04 1995-02-27 METHOD FOR PRODUCING EPOXIES ATE210662T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20607494A 1994-03-04 1994-03-04
PCT/US1995/002347 WO1995023797A1 (en) 1994-03-04 1995-02-27 Process for making an epoxide

Publications (1)

Publication Number Publication Date
ATE210662T1 true ATE210662T1 (en) 2001-12-15

Family

ID=22764868

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95911105T ATE210662T1 (en) 1994-03-04 1995-02-27 METHOD FOR PRODUCING EPOXIES

Country Status (25)

Country Link
EP (1) EP0748319B1 (en)
JP (1) JP3871705B2 (en)
KR (1) KR100387741B1 (en)
CN (1) CN1066728C (en)
AT (1) ATE210662T1 (en)
AU (1) AU690231B2 (en)
BR (1) BR9506977A (en)
CA (1) CA2183976C (en)
CZ (1) CZ291816B6 (en)
DE (1) DE69524578T2 (en)
DK (1) DK0748319T3 (en)
ES (1) ES2167419T3 (en)
FI (1) FI120259B (en)
HR (1) HRP950096B1 (en)
HU (1) HU222750B1 (en)
MX (1) MX9603871A (en)
NZ (1) NZ281866A (en)
PT (1) PT748319E (en)
RO (1) RO117696B1 (en)
RU (1) RU2137769C1 (en)
SK (1) SK283067B6 (en)
TW (1) TW380137B (en)
UA (1) UA45968C2 (en)
WO (1) WO1995023797A1 (en)
YU (1) YU49010B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728840A (en) * 1994-03-04 1998-03-17 Merck & Co., Inc. Process for making an epoxide
TW415948B (en) * 1995-10-30 2000-12-21 Merck & Co Inc Process for synthesizing epoxide and halohydrin
US5981759A (en) * 1997-06-20 1999-11-09 Merck & Co., Inc. Process for indinavir intermediate
KR101274417B1 (en) 2005-11-09 2013-06-17 프로테올릭스, 인코퍼레이티드 Compounds for enzyme inhibition
CA2657213C (en) 2006-06-19 2017-01-03 Proteolix, Inc. Peptide epoxyketones for proteasome inhibition
MY173938A (en) 2007-10-04 2020-02-27 Onyx Therapeutics Inc Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
PE20120059A1 (en) 2008-10-21 2012-02-27 Onyx Therapeutics Inc PHARMACEUTICAL COMBINATIONS WITH PEPTIDIC EPOXYCETONES
TWI504598B (en) 2009-03-20 2015-10-21 Onyx Therapeutics Inc Crystalline tripeptide epoxy ketone protease inhibitors
WO2011060179A1 (en) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Use of peptide epoxyketones for metastasis suppression
MA34133B1 (en) 2010-03-01 2013-04-03 Onyx Therapeutics Inc COMPOUNDS FOR INHIBITORS OF IMMUNOPROTEASOME
KR20130108975A (en) * 2010-04-30 2013-10-07 인디애나 유니버시티 리서치 앤드 테크놀로지 코포레이션 Processes for preparing linezolid
WO2014011695A2 (en) 2012-07-09 2014-01-16 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors
CN104692987B (en) * 2015-01-22 2017-05-17 北京大学 Cheap and efficient synthesis method of halogenated alcohols and derivatives thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides
IL103613A (en) * 1991-11-08 1999-05-09 Merck & Co Inc Hiv protease inhibitors process and intermediats for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU1882895A (en) 1995-09-18
TW380137B (en) 2000-01-21
HU9602412D0 (en) 1996-11-28
HUT75611A (en) 1997-05-28
UA45968C2 (en) 2002-05-15
RO117696B1 (en) 2002-06-28
DE69524578T2 (en) 2002-07-18
WO1995023797A1 (en) 1995-09-08
PT748319E (en) 2002-05-31
FI963452A (en) 1996-09-03
CZ254396A3 (en) 1997-01-15
EP0748319A1 (en) 1996-12-18
DE69524578D1 (en) 2002-01-24
HU222750B1 (en) 2003-09-29
CN1146768A (en) 1997-04-02
KR100387741B1 (en) 2003-10-04
AU690231B2 (en) 1998-04-23
RU2137769C1 (en) 1999-09-20
FI963452A0 (en) 1996-09-03
SK112296A3 (en) 1997-02-05
ES2167419T3 (en) 2002-05-16
CN1066728C (en) 2001-06-06
FI120259B (en) 2009-08-31
HRP950096B1 (en) 2002-06-30
JP3871705B2 (en) 2007-01-24
CA2183976A1 (en) 1995-09-08
YU49010B (en) 2003-04-30
MX9603871A (en) 1997-07-31
CZ291816B6 (en) 2003-06-18
JPH09509929A (en) 1997-10-07
YU14595A (en) 1997-12-05
NZ281866A (en) 1998-05-27
CA2183976C (en) 2005-02-01
EP0748319B1 (en) 2001-12-12
SK283067B6 (en) 2003-02-04
BR9506977A (en) 1997-09-02
HRP950096A2 (en) 1997-06-30
KR970701714A (en) 1997-04-12
DK0748319T3 (en) 2002-03-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name