ATE210291T1 - Neue aryl n-alkylacridancarboxilate zur detektion von chemolumineszenz - Google Patents
Neue aryl n-alkylacridancarboxilate zur detektion von chemolumineszenzInfo
- Publication number
- ATE210291T1 ATE210291T1 AT95913516T AT95913516T ATE210291T1 AT E210291 T1 ATE210291 T1 AT E210291T1 AT 95913516 T AT95913516 T AT 95913516T AT 95913516 T AT95913516 T AT 95913516T AT E210291 T1 ATE210291 T1 AT E210291T1
- Authority
- AT
- Austria
- Prior art keywords
- detecting
- alkylacridane
- carboxilates
- chemoluminescence
- new aryl
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/205,093 US5593845A (en) | 1993-05-17 | 1994-03-02 | Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection |
| PCT/US1995/002568 WO1995023971A1 (en) | 1994-03-02 | 1995-03-01 | Novel aryl n-alkylacridancarboxylate derivatives useful for chemiluminescent detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE210291T1 true ATE210291T1 (de) | 2001-12-15 |
Family
ID=22760771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95913516T ATE210291T1 (de) | 1994-03-02 | 1995-03-01 | Neue aryl n-alkylacridancarboxilate zur detektion von chemolumineszenz |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5593845A (de) |
| EP (1) | EP0750748B1 (de) |
| JP (1) | JP3892035B2 (de) |
| AT (1) | ATE210291T1 (de) |
| CA (1) | CA2184612C (de) |
| DE (1) | DE69524397T2 (de) |
| WO (1) | WO1995023971A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6002000A (en) * | 1992-07-20 | 1999-12-14 | Dade Behring Marburg Gmbh | Chemiluminescent compounds and methods of use |
| WO1994002486A1 (en) * | 1992-07-20 | 1994-02-03 | Syntex (U.S.A.) Inc. | Novel chemiluminescent compounds and methods of use |
| US5593845A (en) * | 1993-05-17 | 1997-01-14 | Lumigen, Inc. | Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection |
| US5723295A (en) * | 1993-05-17 | 1998-03-03 | Lumigen, Inc. | Methods, acridan compounds and kits for producing light |
| US6410732B2 (en) | 1996-01-16 | 2002-06-25 | Lumigen, Inc. | Processing and synthetic intermediates for preparing N-arylacridancarboxylic acid derivatives |
| US5922558A (en) * | 1997-09-12 | 1999-07-13 | Lumigen, Inc. | Methods and compositions for generating chemiluminescence with a peroxidase |
| US6162610A (en) * | 1998-09-11 | 2000-12-19 | Tropix, Inc. | Xanthan-ester and acridan substrates for horseradish peroxidase |
| US6602679B2 (en) | 2000-01-28 | 2003-08-05 | Brij Giri | Stabilized formulations for chemiluminescent assays |
| US7186568B1 (en) | 2000-06-26 | 2007-03-06 | Lumigen Inc. | Electrochemiluminescence from acridan compounds |
| WO2003053934A1 (en) | 2001-12-20 | 2003-07-03 | Lumigen, Inc. | Improved compounds for generating chemiluminescence with a peroxidase |
| US6872828B2 (en) | 2001-12-20 | 2005-03-29 | Lumigen, Inc. | Compounds for generating chemiluminescence with a peroxidase |
| CA2448824A1 (en) * | 2001-06-01 | 2002-12-12 | F. Hoffmann-La Roche Ag | Novel compounds for chemiluminescense procedures |
| US6897036B2 (en) * | 2002-06-06 | 2005-05-24 | Lumigen, Inc. | Fluorescent detection of peroxidase enzymes |
| US6924154B2 (en) * | 2002-08-20 | 2005-08-02 | Quest Diagnostics Investments Incorporated | Hydrophilic chemilumescent acridinium labeling reagents |
| US20050098766A1 (en) * | 2002-09-19 | 2005-05-12 | Watson David L.Jr. | Chemiluminescent processes and systems |
| US7309615B2 (en) * | 2002-09-27 | 2007-12-18 | Siemens Medical Solutions Diagnostic | High quantum yield acridinium compounds and their uses in improving assay sensitivity |
| US7319041B2 (en) * | 2002-09-27 | 2008-01-15 | Siemens Medical Solutions Diagnostic | Applications of acridinium compounds and derivatives in homogeneous assays |
| US7390670B2 (en) | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
| GB0320236D0 (en) * | 2003-08-29 | 2003-10-01 | Molecular Light Tech Res Ltd | Chemiluminescent compounds |
| CA2562684A1 (en) * | 2004-04-14 | 2006-07-13 | Brij P. Giri | New ultra-sensitive chemiluminescent substrates for enzymes and their conjugates |
| US20050272108A1 (en) * | 2004-05-21 | 2005-12-08 | Bhanu Kalra | Stabilized two component system for chemiluminescent assay in immunodiagnostics |
| WO2006116686A2 (en) * | 2005-04-27 | 2006-11-02 | The Trustees Of The University Of Pennsylvania | Nanostructure enhanced luminescent devices |
| WO2006116687A2 (en) * | 2005-04-27 | 2006-11-02 | The Trustees Of The University Of Pennsylvania | Nanoassays |
| US7879575B2 (en) * | 2005-04-27 | 2011-02-01 | The Trustees Of The University Of Pennsylvania | Nanostructures that provide a modified nanoenvironment for the enhancement of luminescence |
| US7799534B2 (en) | 2006-05-09 | 2010-09-21 | Beckman Coulter, Inc. | Nonseparation assay methods |
| US7732153B2 (en) | 2006-05-09 | 2010-06-08 | Beckman Coulter, Inc. | Nonseparation assay methods |
| TW200808974A (en) * | 2006-08-02 | 2008-02-16 | Ind Tech Res Inst | Luminescence-based recipe |
| US7906293B2 (en) * | 2007-04-09 | 2011-03-15 | Abbott Laboratories | Acridinium phenyl esters useful in the analysis of biological |
| WO2009062027A1 (en) * | 2007-11-07 | 2009-05-14 | Beckman Coulter, Inc. | Nonseparation assay methods using peroxide generating enzymes |
| WO2010099486A1 (en) | 2009-02-27 | 2010-09-02 | Beckman Coulter, Inc. | Solution phase homogeneous assays |
| MX2011009020A (es) | 2009-02-27 | 2011-09-29 | Beckman Coulter Inc | Ensayo sin separacion con inhibidores de señal selectiva. |
| WO2020012391A1 (en) | 2018-07-13 | 2020-01-16 | 3M Innovative Properties Company | Assay |
| WO2020012390A1 (en) | 2018-07-13 | 2020-01-16 | 3M Innovative Properties Company | Specific binding chemiluminescent assay |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340590C (en) * | 1986-07-24 | 1999-06-08 | John C. Voyta | Chemiluminescence enhancement |
| US4927769A (en) * | 1987-07-08 | 1990-05-22 | Ciba Corning Diagnostics Corp. | Method for enhancement of chemiluminescence |
| NL8703075A (nl) * | 1987-12-18 | 1989-07-17 | Nederlanden Staat | Acridiniumverbindingen als chemiluminescentie-merkstof. |
| US5281712A (en) * | 1987-12-31 | 1994-01-25 | London Diagnostics, Inc. | Ammonium substituted chemiluminescent labels and their conjugates, and assays therefrom |
| DE68911633T2 (de) * | 1988-09-30 | 1994-04-07 | Fujirebio Kk | Verfahren zur Bestimmung von Peroxidase-Aktivität unter Verwendung von Chemilumineszenz. |
| DK0422252T3 (da) * | 1989-04-28 | 1995-09-11 | Toray Industries | Metode til påvisning af et stof under anvendelse af kemiluminescens |
| JP3584379B2 (ja) * | 1993-02-04 | 2004-11-04 | 持田製薬株式会社 | アクリジニウム化合物およびアクリジニウム化合物複合体 |
| US5491072A (en) * | 1993-05-17 | 1996-02-13 | Lumigen, Inc. | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
| US5593845A (en) * | 1993-05-17 | 1997-01-14 | Lumigen, Inc. | Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection |
| US5523212A (en) * | 1993-05-17 | 1996-06-04 | Lumigen, Inc. | Aryl N-alkylacridanthiocarboxylate derivatives useful for chemiluminescent detection |
-
1994
- 1994-03-02 US US08/205,093 patent/US5593845A/en not_active Expired - Lifetime
-
1995
- 1995-03-01 DE DE69524397T patent/DE69524397T2/de not_active Expired - Lifetime
- 1995-03-01 CA CA002184612A patent/CA2184612C/en not_active Expired - Fee Related
- 1995-03-01 EP EP95913516A patent/EP0750748B1/de not_active Expired - Lifetime
- 1995-03-01 AT AT95913516T patent/ATE210291T1/de active
- 1995-03-01 WO PCT/US1995/002568 patent/WO1995023971A1/en active IP Right Grant
- 1995-03-01 JP JP52301195A patent/JP3892035B2/ja not_active Expired - Lifetime
-
1996
- 1996-02-16 US US08/602,464 patent/US5750698A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2184612C (en) | 2006-01-10 |
| US5750698A (en) | 1998-05-12 |
| DE69524397T2 (de) | 2002-08-08 |
| AU687534B2 (en) | 1998-02-26 |
| WO1995023971A1 (en) | 1995-09-08 |
| EP0750748B1 (de) | 2001-12-05 |
| JPH09509938A (ja) | 1997-10-07 |
| AU2092395A (en) | 1995-09-18 |
| JP3892035B2 (ja) | 2007-03-14 |
| DE69524397D1 (de) | 2002-01-17 |
| EP0750748A1 (de) | 1997-01-02 |
| US5593845A (en) | 1997-01-14 |
| EP0750748A4 (de) | 1997-04-16 |
| CA2184612A1 (en) | 1995-09-08 |
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