ATE203513T1 - A FAMILY OF COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY AND THEIR COMPOSITIONS ALONE OR IN CONJUNCTION WITH REVERSE TRANSCRIPTASE INHIBITORS FOR INHIBITING, AVOIDING OR ELIMINating VIRAL REPLICATION AND METHODS OF USE THEREOF - Google Patents
A FAMILY OF COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY AND THEIR COMPOSITIONS ALONE OR IN CONJUNCTION WITH REVERSE TRANSCRIPTASE INHIBITORS FOR INHIBITING, AVOIDING OR ELIMINating VIRAL REPLICATION AND METHODS OF USE THEREOFInfo
- Publication number
- ATE203513T1 ATE203513T1 AT96928647T AT96928647T ATE203513T1 AT E203513 T1 ATE203513 T1 AT E203513T1 AT 96928647 T AT96928647 T AT 96928647T AT 96928647 T AT96928647 T AT 96928647T AT E203513 T1 ATE203513 T1 AT E203513T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- inflammatory
- inhibiting
- methods
- reverse transcriptase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A new family of compounds having anti-inflammatory, anti-viral, and brocho-dilating activity having the following linear and cyclic formulas: <IMAGE> I (linear form) <IMAGE> II (cyclic form) and compositions of these, which alone, and in combination with reverse transcriptase inhibitors thereby resulting in an additive or synergistic effect, are useful in inhibiting or suppressing viruses including those exhibiting retroviral replication, or in treating viruses including a retrovirus such as HIV in a human cell population and methods of using these compositions, compounds, and salts thereof.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52887995A | 1995-09-15 | 1995-09-15 | |
US08/600,525 US5705522A (en) | 1995-09-15 | 1996-02-13 | Compounds having anti-inflammatory and anti-viral activity, compositions of these, alone and in combination with reverse transcriptase inhibitors |
PCT/IB1996/000942 WO1997010205A1 (en) | 1995-09-15 | 1996-09-13 | A new family of compounds having anti-inflammatory and anti-viral activity and compositions of these, alone and in combination with reverse transcriptase inhibitors, for inhibiting, preventing or eliminating viral replication and methods of using same |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE203513T1 true ATE203513T1 (en) | 2001-08-15 |
Family
ID=27062862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96928647T ATE203513T1 (en) | 1995-09-15 | 1996-09-13 | A FAMILY OF COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY AND THEIR COMPOSITIONS ALONE OR IN CONJUNCTION WITH REVERSE TRANSCRIPTASE INHIBITORS FOR INHIBITING, AVOIDING OR ELIMINating VIRAL REPLICATION AND METHODS OF USE THEREOF |
Country Status (8)
Country | Link |
---|---|
US (1) | US5705522A (en) |
EP (1) | EP0854860B1 (en) |
JP (1) | JP2000511871A (en) |
AT (1) | ATE203513T1 (en) |
AU (1) | AU6835096A (en) |
CA (1) | CA2231996A1 (en) |
DE (1) | DE69614127D1 (en) |
WO (1) | WO1997010205A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6194391B1 (en) * | 1998-06-24 | 2001-02-27 | Emory University | 3′-azido-2′,3′-dideoxyuridine administration to treat HIV and related test protocol |
SK11922002A3 (en) * | 2000-02-18 | 2003-06-03 | Shire Biochem Inc. | Method for the treatment or prevention of flavivirus infections using nucleoside analogues |
US20050087555A1 (en) * | 2003-10-28 | 2005-04-28 | Hatton Jason D. | Fluid dispensing components |
AU2006326404B2 (en) * | 2005-12-14 | 2011-11-03 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
PT2691530T (en) | 2011-06-10 | 2018-05-10 | Univ Oregon Health & Science | Cmv glycoproteins and recombinant vectors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ216172A (en) * | 1985-05-15 | 1989-08-29 | Wellcome Found | Nucleosides and pharmaceutical compositions |
JPS62501712A (en) * | 1985-08-26 | 1987-07-09 | アメリカ合衆国 | Anti-HTLV-3/LAV agent containing 2',3'-dideoxyinosine, 2',3'-dideoxyguanosine or 2',3'-dideoxyadenosine |
US5254539A (en) * | 1985-08-26 | 1993-10-19 | U.S. Government, Dept. Of Health And Human Services, C/O National Institutes Of Health | Method of treating HIV with 2',3'-dideoxyinosine |
FR2646348A1 (en) * | 1989-04-28 | 1990-11-02 | Inst Nat Sante Rech Med | D-ASPARTIC ACID-HYDROXAMATE AS A MEDICINAL PRODUCT |
US5571839A (en) * | 1989-04-28 | 1996-11-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | D-aspartic acid β-hydroxamate for the treatment of viral infections and tumors |
GB9208428D0 (en) * | 1992-04-16 | 1992-06-03 | Proteus Molecular Design | Synthetic polypeptides |
DE69433953T2 (en) * | 1993-05-21 | 2005-08-25 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | New methods for inhibiting the replication of virus-dependent reverse transcriptase by using dideoxynucleotide synthesis inhibitors |
AU1249595A (en) * | 1993-12-20 | 1995-07-17 | Compagnie De Developpment | Mixtures of dideoxynucleosides and d-aspartic acid beta-hydroxamate for inhibiting retroviral spread |
-
1996
- 1996-02-13 US US08/600,525 patent/US5705522A/en not_active Expired - Fee Related
- 1996-09-13 AT AT96928647T patent/ATE203513T1/en not_active IP Right Cessation
- 1996-09-13 EP EP96928647A patent/EP0854860B1/en not_active Expired - Lifetime
- 1996-09-13 AU AU68350/96A patent/AU6835096A/en not_active Abandoned
- 1996-09-13 CA CA002231996A patent/CA2231996A1/en not_active Abandoned
- 1996-09-13 DE DE69614127T patent/DE69614127D1/en not_active Expired - Lifetime
- 1996-09-13 WO PCT/IB1996/000942 patent/WO1997010205A1/en active IP Right Grant
- 1996-09-13 JP JP09511797A patent/JP2000511871A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69614127D1 (en) | 2001-08-30 |
JP2000511871A (en) | 2000-09-12 |
US5705522A (en) | 1998-01-06 |
EP0854860B1 (en) | 2001-07-25 |
AU6835096A (en) | 1997-04-01 |
WO1997010205A1 (en) | 1997-03-20 |
CA2231996A1 (en) | 1997-03-20 |
EP0854860A1 (en) | 1998-07-29 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |