ATE203416T1 - HEAVY METAL CLUSTER FOR USE AS IMAGING AGENTS - Google Patents

HEAVY METAL CLUSTER FOR USE AS IMAGING AGENTS

Info

Publication number
ATE203416T1
ATE203416T1 AT92912155T AT92912155T ATE203416T1 AT E203416 T1 ATE203416 T1 AT E203416T1 AT 92912155 T AT92912155 T AT 92912155T AT 92912155 T AT92912155 T AT 92912155T AT E203416 T1 ATE203416 T1 AT E203416T1
Authority
AT
Austria
Prior art keywords
heavy metal
imaging agents
metal cluster
atoms
cluster
Prior art date
Application number
AT92912155T
Other languages
German (de)
Inventor
Edward A Deutsch
Karen F Deutsch
Dennis L Nosco
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE203416T1 publication Critical patent/ATE203416T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent

Abstract

The present invention relates to novel compounds for use as imaging agents. In particular, the present invention relates to imaging agents comprising a heavy metal cluster having 2 to 8 atoms of the same of different heavy metal elements, and at least one coordinating ligand having 1 to 8 atoms which bond to the cluster, and a number of supporting atoms making up the framework of the ligand.
AT92912155T 1991-08-05 1992-05-13 HEAVY METAL CLUSTER FOR USE AS IMAGING AGENTS ATE203416T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69984891A 1991-08-05 1991-08-05
PCT/US1992/003984 WO1993002713A1 (en) 1991-08-05 1992-05-13 Heavy metal clusters for use as imaging agents

Publications (1)

Publication Number Publication Date
ATE203416T1 true ATE203416T1 (en) 2001-08-15

Family

ID=24811176

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92912155T ATE203416T1 (en) 1991-08-05 1992-05-13 HEAVY METAL CLUSTER FOR USE AS IMAGING AGENTS

Country Status (9)

Country Link
US (1) US5417958A (en)
EP (1) EP0597865B1 (en)
JP (1) JPH06510759A (en)
AT (1) ATE203416T1 (en)
AU (1) AU670029B2 (en)
CA (1) CA2113997A1 (en)
DE (1) DE69231966T2 (en)
ES (1) ES2157902T3 (en)
WO (1) WO1993002713A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9006977D0 (en) * 1990-03-28 1990-05-23 Nycomed As Compositions
AU7261994A (en) * 1993-07-19 1995-02-20 Resolution Pharmaceuticals Inc. Hydrazino-type radionuclide chelators having an n3s configuration
US5858327A (en) * 1993-09-03 1999-01-12 Resolutions Pharmaceuticals, Inc. Hydrazino-type N2 S2 radionuclide chelating compounds
US5574140A (en) * 1993-09-03 1996-11-12 Resolution Pharmaceutical Inc. Hydrazino-type N2 S2 chelators
WO1996019487A1 (en) * 1994-12-22 1996-06-27 Nissan Chemical Industries, Ltd. Organobismuth derivatives and process for producing the same
GB9501560D0 (en) 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
WO1996022994A1 (en) * 1995-01-26 1996-08-01 Nycomed Imaging A/S Bismuth compounds
US5717121A (en) * 1995-06-07 1998-02-10 Nycomed Salutar, Inc. Preparation and use of contrast agents
DE19631544A1 (en) * 1995-08-03 1997-02-06 Schering Ag Diagnostic or radiotherapy compsns. contg. metal clusters - e.g. as X=ray or NMR contrast agents, having good compatibility and stability in vivo and in vitro
GB9601340D0 (en) * 1996-01-23 1996-03-27 Nycomed Salutar Inc Contrast media
IL127314A0 (en) * 1998-11-27 1999-09-22 Algotec Systems Ltd A method for forming a perspective rendering from a voxel space
ES2277531B2 (en) * 2005-08-03 2008-07-16 Universidad De Santiago De Compostela PROCEDURE FOR OBTAINING ATOMIC QUANTIC CLUSTERS.
US9746985B1 (en) 2008-02-25 2017-08-29 Georgetown University System and method for detecting, collecting, analyzing, and communicating event-related information
DE102010050312A1 (en) 2010-11-03 2012-05-03 Süd-Chemie AG Ammonia oxidation catalyst with low N2O by-product formation
CN109939245B (en) * 2019-02-27 2021-08-03 上海师范大学 Paramagnetic nano material, preparation method thereof and application of paramagnetic nano material as nuclear magnetic resonance contrast agent

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL135286C (en) * 1967-05-03
US3832457A (en) * 1969-06-20 1974-08-27 Rikagaku Kenkyusho Ferrite contrast media with metallic oxides
US4176173A (en) 1977-07-18 1979-11-27 Medi-Physics, Inc. Radiographic compositions
US4310507A (en) * 1978-08-02 1982-01-12 Eastman Kodak Company Contrast agent for radiography
US4292253A (en) * 1979-04-03 1981-09-29 Ozin Geoffrey A Organo-metal catalysts and processes for their preparation
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
FR2630547A1 (en) 1988-04-22 1989-10-27 Centre Nat Rech Scient COLD MARKING OF MOLECULES OF PEPTIDE OR PROTEIN NATURE
CA1319926C (en) * 1988-06-17 1993-07-06 Helmut X. Huber Catalytic metal clusters and processes for their preparation
EP0361960A3 (en) * 1988-09-29 1992-01-02 RANNEY, David F. Methods and compositions for magnetic resonance imaging
WO1991014660A1 (en) 1990-03-20 1991-10-03 Olaf Fritz Dielenberg Inhibiting corrosion of reinforcements in concrete
GB9006977D0 (en) * 1990-03-28 1990-05-23 Nycomed As Compositions

Also Published As

Publication number Publication date
EP0597865B1 (en) 2001-07-25
WO1993002713A1 (en) 1993-02-18
AU670029B2 (en) 1996-07-04
JPH06510759A (en) 1994-12-01
ES2157902T3 (en) 2001-09-01
DE69231966T2 (en) 2001-11-15
DE69231966D1 (en) 2001-08-30
EP0597865A1 (en) 1994-05-25
CA2113997A1 (en) 1993-02-18
US5417958A (en) 1995-05-23
AU1996692A (en) 1993-03-02

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Legal Events

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