ATE199555T1 - HETEROCYCLIC ESTERS OF RAPAMYCIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

HETEROCYCLIC ESTERS OF RAPAMYCIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
ATE199555T1
ATE199555T1 AT95901258T AT95901258T ATE199555T1 AT E199555 T1 ATE199555 T1 AT E199555T1 AT 95901258 T AT95901258 T AT 95901258T AT 95901258 T AT95901258 T AT 95901258T AT E199555 T1 ATE199555 T1 AT E199555T1
Authority
AT
Austria
Prior art keywords
rapamycin
pharmaceutical compositions
compositions containing
heterocyclic esters
hydrogen
Prior art date
Application number
AT95901258T
Other languages
German (de)
Inventor
Frances Christy Nelson
Guy Alan Schiehser
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE199555T1 publication Critical patent/ATE199555T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

A compound of the structure <IMAGE> wherein R and R1 are each, independently, <IMAGE> or hydrogen, R2 is a heterocyclic radical which may be optionally substituted; n=0-6; with the proviso that R and R1 are both not hydrogen, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.
AT95901258T 1993-11-22 1994-11-16 HETEROCYCLIC ESTERS OF RAPAMYCIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ATE199555T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/156,208 US5385909A (en) 1993-11-22 1993-11-22 Heterocyclic esters of rapamycin
PCT/US1994/013411 WO1995014697A1 (en) 1993-11-22 1994-11-16 Heterocyclic esters of rapamycin and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE199555T1 true ATE199555T1 (en) 2001-03-15

Family

ID=22558576

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95901258T ATE199555T1 (en) 1993-11-22 1994-11-16 HETEROCYCLIC ESTERS OF RAPAMYCIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (14)

Country Link
US (1) US5385909A (en)
EP (1) EP0730597B1 (en)
JP (1) JPH09505596A (en)
AT (1) ATE199555T1 (en)
AU (1) AU1057195A (en)
CA (1) CA2176961A1 (en)
DE (1) DE69426831T2 (en)
DK (1) DK0730597T3 (en)
ES (1) ES2154720T3 (en)
GR (1) GR3035835T3 (en)
HK (1) HK1011354A1 (en)
PT (1) PT730597E (en)
SG (1) SG47629A1 (en)
WO (1) WO1995014697A1 (en)

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Also Published As

Publication number Publication date
HK1011354A1 (en) 1999-07-09
ES2154720T3 (en) 2001-04-16
EP0730597B1 (en) 2001-03-07
US5385909A (en) 1995-01-31
DE69426831T2 (en) 2009-09-10
EP0730597A1 (en) 1996-09-11
PT730597E (en) 2001-06-29
DE69426831D1 (en) 2001-04-12
SG47629A1 (en) 1998-04-17
DK0730597T3 (en) 2001-04-17
JPH09505596A (en) 1997-06-03
AU1057195A (en) 1995-06-13
GR3035835T3 (en) 2001-08-31
CA2176961A1 (en) 1995-06-01
WO1995014697A1 (en) 1995-06-01

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