ATE192442T1 - Succinic acid monoamide compound, process for its production and its use - Google Patents

Succinic acid monoamide compound, process for its production and its use

Info

Publication number
ATE192442T1
ATE192442T1 AT94921848T AT94921848T ATE192442T1 AT E192442 T1 ATE192442 T1 AT E192442T1 AT 94921848 T AT94921848 T AT 94921848T AT 94921848 T AT94921848 T AT 94921848T AT E192442 T1 ATE192442 T1 AT E192442T1
Authority
AT
Austria
Prior art keywords
pharmaceutically acceptable
succinamic acid
acceptable salt
acid compound
present
Prior art date
Application number
AT94921848T
Other languages
German (de)
Inventor
Hiroshi Hosono
Toshiyuki Nishio
Hiromichi Ishikawa
Yoshiyuki Nakamura
Tetsuo Matsui
Original Assignee
Senju Pharma Co
Yoshitomi Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharma Co, Yoshitomi Pharmaceutical filed Critical Senju Pharma Co
Application granted granted Critical
Publication of ATE192442T1 publication Critical patent/ATE192442T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Provision of a succinamic acid compound of the formula (1) <CHEM> wherein R<1> is an alkyl or a lower alkenyl and R<2> is an optionally esterified carboxyl, a pharmaceutically acceptable salt thereof, an agent for the prophylaxis and/or treatment of the complications of diabetes, comprising, as an active ingredient, the succinamic acid compound or a pharmaceutically acceptable salt thereof, an aldose reductase inhibitor comprising, as an active ingredient, the succinamic acid compound or a pharmaceutically acceptable salt thereof, and a method for producing the succinamic acid compound or a pharmaceutically acceptable salt thereof. The novel succinamic acid compounds of the formula (1) of the present invention and pharmaceutically acceptable salts thereof have a strong aldose reductase inhibitory activity in mammals such as human, and show superior safety. Hence, they are useful as pharmaceutical agents for the treatment of the complications of diabetes such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, in particular, cataract and neurosis. According to the production method of the present invention, efficient production of such useful compounds of the present invention can be provided.
AT94921848T 1993-09-14 1994-08-01 Succinic acid monoamide compound, process for its production and its use ATE192442T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5250925A JPH0782259A (en) 1993-09-14 1993-09-14 Succinamic acid derivative and medicine containing the same for therapy of diabetic complications
PCT/JP1994/001266 WO1995007898A1 (en) 1993-09-14 1994-08-01 Succinamic acid compound, process for producing the same, and use thereof

Publications (1)

Publication Number Publication Date
ATE192442T1 true ATE192442T1 (en) 2000-05-15

Family

ID=17215069

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94921848T ATE192442T1 (en) 1993-09-14 1994-08-01 Succinic acid monoamide compound, process for its production and its use

Country Status (12)

Country Link
US (1) US5688818A (en)
EP (1) EP0719767B1 (en)
JP (1) JPH0782259A (en)
KR (1) KR960704870A (en)
CN (1) CN1134699A (en)
AT (1) ATE192442T1 (en)
AU (1) AU680670B2 (en)
CA (1) CA2171756A1 (en)
DE (1) DE69424295T2 (en)
ES (1) ES2145142T3 (en)
TW (1) TW324719B (en)
WO (1) WO1995007898A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1295476A (en) 1998-01-30 2001-05-16 株式会社·R-技术上野 Ophthalmic composition
EP1848541A4 (en) * 2005-02-07 2013-01-16 Pharmalight Inc Method and device for ophthalmic administration of active pharmaceutical ingredients
TWI266901B (en) 2005-12-26 2006-11-21 Au Optronics Corp Color filter and method for fabricating the same
MA53707A (en) * 2018-09-25 2021-12-29 Antabio Sas INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
JP3126541B2 (en) * 1993-03-26 2001-01-22 千寿製薬株式会社 Benzothiazole derivatives, their preparation and their use

Also Published As

Publication number Publication date
WO1995007898A1 (en) 1995-03-23
EP0719767A1 (en) 1996-07-03
EP0719767B1 (en) 2000-05-03
DE69424295D1 (en) 2000-06-08
KR960704870A (en) 1996-10-09
DE69424295T2 (en) 2000-10-26
EP0719767A4 (en) 1997-01-08
TW324719B (en) 1998-01-11
JPH0782259A (en) 1995-03-28
CN1134699A (en) 1996-10-30
CA2171756A1 (en) 1995-03-23
ES2145142T3 (en) 2000-07-01
AU680670B2 (en) 1997-08-07
US5688818A (en) 1997-11-18
AU7238994A (en) 1995-04-03

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties